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Chemical/ionic/physical compounding cross linking hydrogel and preparation method thereof

A technology of cross-linked hydrogel and chemical cross-linking agent is applied in the field of chemical/ionic/physical composite cross-linked hydrogel and its preparation, which can solve the problem of low responsiveness, non-uniformity, single ionic cross-linked gel Physically cross-linked gel comprehensively has poor mechanical properties and other problems, and achieves the effects of mild conditions, short reaction time and simple preparation method.

Active Publication Date: 2013-02-06
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The object of the present invention is to provide a chemical / ionic / physical compound cross-linked hydrogel and its preparation method, which can overcome the traditional single chemical cross-linked gel network inhomogeneity, single ion cross-linked gel low responsiveness and single physical cross-linked hydrogel. Disadvantages of poor comprehensive mechanical properties of joint gel

Method used

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  • Chemical/ionic/physical compounding cross linking hydrogel and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] 1) Preparation of chemical / physical cross-linking gel pre-polymerization solution: add 0.001g hectorite, 1g acrylamide and 0.001g methylenebisacrylamide to deionized water in sequence to prepare an aqueous solution with a mass concentration of 10%. Stir for 20 minutes each time the raw materials are added until a uniform pre-polymerized liquid is formed;

[0037] 2) Preparation of chemical / ionic / physical cross-linking gel pre-polymerization solution: under nitrogen protection and magnetic stirring, slowly add 0.1g of sodium alginate to the pre-polymerization solution in step 1, and add it immediately after no aggregates appear 0.01g calcium sulfate and 0.1% plasticizer glycerin in mass concentration, stirring at low speed for 5min;

[0038] 3) Preparation of chemical / ion / physical composite cross-linked gel: when the gel prepolymerization liquid in step 2 has a viscous appearance, immediately add 0.1g initiator ammonium persulfate, 0.003g catalyst tetramethylethyl ether ...

Embodiment 2

[0042] 1) Preparation of chemical cross-linking gel pre-polymerization solution: Add 2 g of isopropylacrylamide and 0.002 g of methylenebisacrylamide to deionized water in sequence to prepare an aqueous solution with a mass concentration of 9%, and after each addition of raw materials , and stirred for 25 minutes until a uniform pre-polymerized solution was formed;

[0043] 2) Preparation of chemical / ion cross-linked gel pre-polymerization solution: under nitrogen protection and magnetic stirring, slowly add 0.1g sodium alginate and 0.05g chitosan to the pre-polymerization solution in step 1 until no aggregates appear After that, immediately add 0.02g calcium sulfate and 0.1% plasticizer glycerin with a mass concentration, and stir at a low speed for 7 minutes;

[0044] 3) Preparation of chemical / ionic composite cross-linked gel: when the gel prepolymerization solution in step 2 has a viscous appearance, immediately add 0.2g initiator potassium persulfate, 0.006g catalyst sodi...

Embodiment 3

[0048] 1) Preparation of chemical / physical cross-linking gel pre-polymerization solution: add 0.002g lithium magnesium silicate, 1g methylol acrylamide and 0.01g glutaraldehyde into deionized water in sequence to prepare an aqueous solution with a mass concentration of 11%. , each time the raw materials are added, stir for 20 minutes until a uniform pre-polymerized liquid is formed;

[0049] 2) Preparation of chemical / ionic / physical cross-linking gel pre-polymerization solution: under nitrogen protection and magnetic stirring, slowly add 0.05g sodium alginate and 0.05g polylysine to the pre-polymerization solution in step 1, and wait until no After the agglomerates appear, immediately add 0.005 calcium phosphate and 0.1% plasticizer glycerin, and stir at low speed for 8 minutes;

[0050] 3) Preparation of chemical / ion / physical composite cross-linked gel: when the gel pre-polymerization liquid in step 2 has a viscous appearance, immediately add 0.1g initiator potassium persulfa...

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Abstract

The invention relates to chemical / ionic / physical compounding cross linking hydrogel and a preparation method thereof. The hydrogel is polymerized in a way that olefin monomer M1, a chemical cross-linking agent M2, multivalent ion biomacromolecule M3, an ionic cross-linking agent M4 and a physical cross-linking agent M5 are dissolved in water. The method comprises the following steps: preparing chemical / physical cross linked gel prepolymerization liquid, preparing chemical / ionic / physical cross linked gel prepolymerization liquid and preparing and purifying chemical / ionic / physical compounding cross linked gel. According to the invention, the characteristics and properties of the chemical cross-linking agent, the physical cross-linking agent and the ionic cross-linking agents are taken into consideration comprehensively, the compounding cross linking of molecular chains is realized; the prepared hydrogel is optically transparent and has higher mechanical ductility and rebound elasticity; the mechanic, optical and thermal performances and other performances can be regulated conveniently by controlling technology parameters and conditions; and the prepared hydrogel can be used in the fields such as tissue engineering, food industry, agricultural irrigation, daily chemical engineering, oil production, dye adsorption and biological medicine.

Description

technical field [0001] The invention relates to the fields of polymer materials, biomedicine and environmental protection, in particular to a chemical / ionic / physical compound cross-linked hydrogel and a preparation method thereof. Background technique [0002] Hydrogel is a kind of polymer with a three-dimensional network structure, which can absorb a large amount of water and swell in water, and can continue to maintain its original structure without being dissolved after swelling. Because of their unique water absorption, water retention, and biomimetic properties, hydrogels are widely used in industries, agriculture, chemicals, medicine, and bioengineering. The three-dimensional network of polymer hydrogels is generally formed by physical cross-linking or chemical cross-linking methods. The preparation of polymer gel by chemical synthesis is the main gel preparation method at present. [0003] Chemically cross-linked hydrogels are covalently cross-linked networks formed...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/24C08J3/075C08F251/00C08F291/00
Inventor 张青松黄秀晶王万俊郭袈陈莉
Owner TIANJIN POLYTECHNIC UNIV
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