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Application of geniposide

A technology of geniposide and ionizing radiation, which is applied in the application field of traditional Chinese medicine components, can solve problems that have not been reported, and achieve the effect of reducing radiation damage and enhancing the body's immunity

Active Publication Date: 2014-12-03
INST OF MODERN PHYSICS CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Geniposide and its metabolites have strong pharmacological activity. In the past ten years, domestic and foreign scholars have done a lot of research on the active ingredients, extract analysis, pharmacology and application of geniposide, and achieved gratifying results. , but there are no reports on the effects of geniposide and its metabolites on radiation-induced lung injury caused by radiotherapy for chest tumors, aerospace and nuclear radiation, etc.

Method used

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  • Application of geniposide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Geniposide relieves radiation-induced lung injury and decreased immunity of the body caused by X-ray irradiation to treat malignant tumors.

[0032] 1.1 Experimental materials

[0033] Geniposide, purchased from Shanghai Yuanye Biotechnology Co., Ltd., purity ≥98% (determined by HPLC method). The Lewis lung cancer cell line was purchased from the China Type Culture Collection (Wuhan University Collection), and was inoculated into the right axillary of C57BL / 6 mice for subcutaneous passage.

[0034] 1.2 Experimental method

[0035] On the ultra-clean workbench, the tumor-bearing mice were sacrificed by removing the cervical spine and fixed on the board. Disinfect animal skin with iodine tincture and alcohol, cut the skin, select tumor tissues with good tumor growth without necrosis or liquefaction, add sterile normal saline, and use a tissue homogenizer to prepare a cell suspension containing about 30 million / ml. 120 C57BL / 6 mice were inoculated subcutaneously in t...

Embodiment 2

[0047] Example 2: Geniposide alleviates the radiation-induced lung injury caused by heavy ion beam irradiation in the treatment of malignant tumors and the reduction of immunity

[0048] 2.1 Experimental material: Geniposide, purchased from Shanghai Yuanye Biotechnology Co., Ltd., with a purity of 99.8% (determined by HPLC method). The U14 cervical cancer cell line was purchased from the Beijing Institute of Materia Medica, Chinese Academy of Medical Sciences, and was inoculated into the abdominal cavity of Kunming mice for preservation.

[0049] 2.2 Experimental method:

[0050] Take the passaged mice that have been inoculated with U14 cervical cancer ascites for 7 days, disinfect the abdomen, take the milky ascites with a sterile syringe, and dilute with 5 times the volume of normal saline for injection. After disinfecting the skin of the groin area of ​​the right posterior branch, 120 mice were inoculated subcutaneously with 0.2 ml of the above tumor cell suspension. On the 10t...

Embodiment 3

[0059] Example 3: The radioprotective effect of geniposide on lung injury caused by γ-ray radiotherapy

[0060] 3.1 Experimental material Geniposide was purchased from Shanghai Yuanye Biotechnology Co., Ltd., with a purity of 99.8% (determined by HPLC method). The H22 hepatoma cell line was purchased from the Beijing Institute of Materia Medica, Chinese Academy of Medical Sciences, and was inoculated into the abdominal cavity of Kunming mice for preservation.

[0061] 3.2 Experimental method:

[0062] Passage mice that have been inoculated with H22 liver cancer ascites for 7 days are taken, the abdomen is sterilized, and the milky ascites is taken with a sterile syringe, and diluted with 5 times the volume of normal saline for injection. After disinfecting the skin of the groin area of ​​the right posterior branch, 120 mice were inoculated subcutaneously with 0.2 ml of the above tumor cell suspension. On the 10th day after tumor inoculation, mice with tumor masses greater than 1 ...

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Abstract

The invention discloses an application of geniposide in preparation of medicines for treating and preventing a radioactive lung injury caused by ionizing radiations. The geniposide as the medicines for treating and preventing the radioactive lung injury caused by aerospace, nuclear radiation and thoracic cancer radiotherapy strengthens the immunity of the organism to alleviate the radiation injury, so that the geniposide can provide a selective radiation protection idea for the radioactive lung injury caused by ionizing radiations, including an aerospace business, a nucleus scientific and technological development and a breast cancer radiotherapy and the like.

Description

technical field [0001] The invention relates to the application of a traditional Chinese medicine component, in particular to the application of geniposide in the preparation of medicines for treating and preventing radiation-induced lung injury caused by ionizing radiation. Background technique [0002] With the rapid development of the national economy and science and technology, the rapid improvement of people's living standards, the rapid development of the aerospace industry, and the extensive application of nuclear energy and nuclear technology in medical and health, scientific research, industrial and agricultural production, and national defense, radiation and people People's work and daily life are getting closer and closer, more and more people are exposed to radiation, and the damage is getting more and more serious. The potential huge danger cannot be ignored [Cong Yue, Rao Yalan, Chen Xiaohua, etc.]. Preliminary study on the effect of radiation induction on the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P11/00
Inventor 武振华张红王振华王新宇
Owner INST OF MODERN PHYSICS CHINESE ACADEMY OF SCI
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