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Theranostic agent and preparation method thereof

A technology for reagents and preparations is applied in the field of integrated diagnosis and treatment reagents and their preparation, and achieves the effects of being simple and easy to prepare, improving the efficiency of diagnosis and treatment, and saving time.

Inactive Publication Date: 2013-01-30
戴志飞
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to obtain an integrated reagent for diagnosis and treatment, to solve various inconveniences caused by single use of diagnosis or treatment in traditional clinical practice, and to realize both functions of diagnosis and treatment at the same time with a compound preparation

Method used

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  • Theranostic agent and preparation method thereof
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  • Theranostic agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0027] (1) Weigh 100mg of polylactide and dissolve it in 4mL of dichloromethane under rapid stirring, absorb 0.06mL of perfluorooctylbromide into the solution and mix well, slowly pour the organic phase into 20mL of 2% polyvinyl alcohol solution and place In an ice bath, use a probe ultrasonic instrument at a power of 300W for 120s, then magnetically stir for 2h to completely volatilize dichloromethane, then centrifuge at 15000g for 5min, collect the precipitate and wash it with water under the same centrifugation conditions to obtain polymer-wrapped Liquid fluorocarbon nanoparticles;

[0028] (2) Take 100 μL of liquid fluorocarbon nanoparticle suspension and add 25 mL of 1 mg / mL polyallylamine hydrochloride, after adsorption for 15 min, centrifuge at 15,000 g for 5 min, collect the precipitate and wash it with water under the same centrifugation conditions, then add citric acid For sodium-stabilized gold nanoparticles, repeat the adsorption-centrifugation-washing process to o...

specific Embodiment approach 2

[0031] (1) Weigh 250mg of polylactide and dissolve it in 10mL of dichloromethane under rapid stirring, draw 0.1mL of perfluoropentane into the solution and mix well, slowly pour the organic phase into 50mL of 1% polyvinyl alcohol solution and place In an ice bath, use a probe ultrasonic instrument at a power of 500W for 150s, then magnetically stir for 3 hours to completely volatilize the dichloromethane, then centrifuge at 12000g for 5 minutes, collect the precipitate and wash it with water under the same centrifugation conditions to obtain a liquid state wrapped in polymer Fluorocarbon nanoparticles;

[0032] (2) Take 50 μL of liquid fluorocarbon nanoparticle suspension and add 10 mL of 1 mg / mL polyallylamine hydrochloride, after adsorption for 15 min, centrifuge at 12000 g for 5 min, collect the precipitate and wash it with water under the same centrifugation conditions, then add citric acid For sodium-stabilized gold nanoparticles, repeat the adsorption-centrifugation-wash...

specific Embodiment approach 3

[0036] (1) Weigh 100 mg of polyglycolide lactide copolymer and dissolve it in 5 mL of chloroform under rapid stirring, draw 0.05 mL of perfluorooctyl bromide into the solution and mix well, slowly pour the organic phase into 25 mL of 2% poly Vinyl alcohol solution and placed in an ice bath, using a probe ultrasonic instrument at a power of 300W for 100s, then magnetically stirred for 2h to completely volatilize the chloroform, centrifuged at 15000g for 3min, collected the precipitate and washed it with water under the same centrifugation conditions to obtain Liquid fluorocarbon nanoparticles wrapped in polymer;

[0037] (2) Take 200 μL of liquid fluorocarbon nanoparticle suspension and add 25 mL of 1 mg / mL polyallylamine hydrochloride, after adsorption for 15 min, centrifuge at 15,000 g for 3 min, collect the precipitate and wash it with water under the same centrifugation conditions, then add citric acid For sodium-stabilized gold nanoparticles, repeat the adsorption-centrifu...

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Abstract

The invention relates to a theranostic agent and a preparation method thereof. The prepared theranostic agent consists of internal liquid fluorocarbon nanoparticles and an external gold nanoshell. With the functions of ultrasonic contrast imaging diagnosis and photothermal treatment at the same time, the theranostic agent successfully integrates real-time, efficient, low-cost and radiationless contrast-enhanced ultrasound diagnosis with high selectivity, high efficacy near-infrared photothermal treatment. By means of only one composite agent, the diagnosis and treatment functions can be realized simultanesouly. Due to integration of diagnosis and treatment, intermediate links are reduced, diagnosis and treatment efficiency can be enhanced, and toxic and side effects are lowered at the same time. Thus, the theranostic agent has very good clinical application potential.

Description

technical field [0001] The invention relates to an integrated reagent for diagnosis and treatment and a preparation method thereof. Background technique [0002] In traditional clinical practice, disease diagnosis and treatment are two opposite processes, and contrast agents for diagnosis and drugs for treatment also need to be used separately. The time interval between two medical procedures is long, and for some acute diseases, it is easy to miss the best time for treatment. At the same time, the side effects caused by the two medications will also increase the pain and risk of patients. Therefore, in order to solve this situation, with the joint efforts of clinicians and scientific researchers, in recent years, a new way of disease treatment - theranostics has been gradually developed as a new concept. Theranostics combines the two processes of diagnosis and treatment into one, and when the diagnosis result is obtained, symptomatic treatment is immediately carried out ba...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22A61K41/00A61N5/06
Inventor 戴志飞柯亨特王金锐
Owner 戴志飞
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