Application of Gypensapogenin A in medicine for treating hemorrhagic fever with renal syndrome

A technology for renal syndrome and hemorrhagic fever, applied in the direction of drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as uncertain effects, and achieve strong inhibitory activity of hemorrhagic fever with renal syndrome virus and highlight the essence The effect of sexuality

Inactive Publication Date: 2013-01-23
吴俊华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antiviral treatments such as ribavirin and interferon are often used clinically, but the effect is not yet certain

Method used

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  • Application of Gypensapogenin A in medicine for treating hemorrhagic fever with renal syndrome
  • Application of Gypensapogenin A in medicine for treating hemorrhagic fever with renal syndrome
  • Application of Gypensapogenin A in medicine for treating hemorrhagic fever with renal syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of the compound Gypensapogenin A tablet involved in the present invention:

[0013] Take 20 grams of compound Gypensapogenin A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tabletting machine.

Embodiment 2

[0014] Embodiment 2: The preparation of the compound Gypensapogenin A capsules involved in the present invention:

[0015] Get 20 grams of compound Gypensapogenin A, add conventional auxiliary materials such as starch 180 grams for the preparation of capsules, mix well, and pack into capsules to make 1000 tablets.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

[0017] In order to better understand the essence of the present invention, the following experimental research results of Gypensapogenin A will be used to illustrate its application in the field of pharmacy.

[0018] The specific experiment is as follows:

[0019] 1. Experimental study of Gypensapogenin A against hemorrhagic fever with renal syndrome virus

[0020] (1) In vitro inhibition experiment of hemorrhagic fever with renal syndrome virus

[0021] 1 material

[0022] (1) Virus strain: the international standard strain of hemorrhagic fever with renal syndrome vir...

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Abstract

The invention discloses a new application of Gypensapogenin A in preparation for a medicine for treating hemorrhagic fever with renal syndrome. Experimental studies on the in-vitro inhibition and the in-vivo inhibition of Gypensapogenin A for hemorrhagic fever with renal syndrome show that Gypensapogenin A has a low toxic effect on cells, plays a role of directly killing the virus of hemorrhagic fever with renal syndrome, can obviously inhibit the multiplication of the virus, and plays an obvious role of protecting hamsters infected with the virus so as to delay the onset time, prolong the disease course and decrease the mortality. Thus, Gypensapogenin A is an effective and safe medicine for treating the hemorrhagic fever with the renal syndrome.

Description

technical field [0001] The present invention relates to the use of Gypensapogenin A, in particular to the use of Gypensapogenin A in the pharmaceutical field. Background technique [0002] There are 13 kinds of human viral hemorrhagic fever in the world. According to whether the disease has kidney damage, it is divided into two categories: with kidney damage and without kidney damage. In my country, it is mainly hemorrhagic fever with renal syndrome (HFRS), also known as epidemic hemorrhagic fever. Hemorrhagic fever (EHF); called Korean hemorrhagic fever (KHF) in North Korea; called hemorrhagic nephritis nephritis (HNN) in the Soviet Union; due to the establishment of specific serological diagnosis and the resolution of etiology, in 1982, the World Health Organization named it as renal syndrome Symptoms of hemorrhagic fever. [0003] The disease is caused by Korean hemorrhagic fever virus (or Hantaan virus), a natural foci disease with rodents as the main source of infection;...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61P31/14A61P13/12
Inventor 王泽正俞骁吴俊华
Owner 吴俊华
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