Application of jatrorrhizine for treating candida albicans infectious diseases

Abstract

The invention discloses a novel application of jatrorrhizine for treating candida albicans infectious diseases. The jatrorrhizine can be extracted from plants of coptis roots, amur corktree barks, caulis mahoniae and the like. The study shows that half bacteriostasis concentration of the jatrorrhizine to candida albicans is 139+ / -21mg / L, and effective dose of the jatrorrhizine for enhancing body resistibility of a low immune function mouse to the candida albicans is 30mg / Kg. The jatrorrhizine and pharmaceutically acceptable salts, esters or sugars, excipients and the like are utilized for preparing medicines for treating diseases caused by the fact that the candida albicans infect human and livestock, and the jatrorrhizine can be applied to, but is not limited to, medicines for treating human skins, mucous membranes, internal organs or nervous centralis candidiasis, livestock upper digestive tract mycoses and the like. The jatrorrhizine and the pharmaceutically acceptable salts, esters or sugars and excipients and the like can be prepared to be injection, oral administration and external preparations and dosage forms thereof which are pharmaceutically acceptable such as injections, tablets, capsules, liniments, pastes, smearing agents, emulsions, nanoparticle emulsions, and the like.

Description

Technical field [0001] The present invention relates to a new application of jatrorrhizine, in particular to the application of jatrorrhizine in the preparation of medicines for the prevention and treatment of Candida albicans infectious diseases in humans, livestock and poultry, especially human skin candidiasis and mucous membranes caused by Candida albicans infection. Candidiasis, visceral or central nervous candidiasis, pneumonia, gastroenteritis, endocarditis, meningitis, encephalitis and other diseases caused by the spread of pathogens on the mucous membranes and skin, and fungal diseases of the upper gastrointestinal tract of livestock and poultry. Background technique [0002] Candida albicans (Monilia albican or canidia Albicans) is a fungus that usually exists in the oral cavity, upper respiratory tract, intestinal tract and vagina of normal people and livestock such as chickens and ducks. It generally has a small number in normal organisms and does not cause diseas...

AI Technical Summary

Problems solved by technology

[0007] The main problems in the treatment of Candida albicans infection are: (1) there is still a lack of specific drugs; (2) the comprehensive treatment procedure is complicated and the treatment cycle is long; (3) most of the currently used therapeutic drugs are resistant to There are toxic side effects such as digestive system; (4) The disease recurrence rate is high, and there are few optional therapeutic drugs

(4) Reversal of multidrug resistance

However, research on the pharmacological effects of jatrorrhizine against Candida albicans and its use in the treatment of all diseases caused by Candida albicans infection in humans, livestock and poultry, including but not limited to human skin candidiasis, mucosal candidiasis, internal organs or central nervous system Candidiasis and pneumonia, gastroenteritis, endocarditis, meningitis, encephalitis and other diseases caused by the spread of germs on the mucous membranes and skin, etc., and fungal diseases of the upper gastrointestinal tract of livestock and poultry have not been reported at home and abroad.

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