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Antibody-based targeting medicine used for repairing damaged tissues, administration method, and magnetic resonance imaging contrast agent

An antibody-targeted and damaged tissue technology, applied in the direction of antibodies, drug combinations, and pharmaceutical formulations, can solve problems such as tumors, immune rejection, and unclear mechanisms of stem cell therapy, and achieve enhanced targeting and optimized repair functions Effect

Inactive Publication Date: 2012-12-26
SUZHOU WANMUCHUN BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, stem cell therapy has great limitations: 1) autologous stem cells are not easy to obtain, and allogeneic transplantation may lead to severe immune rejection; 2) studies have shown that transplanted stem cells may produce tumors; 3) the use of embryonic stem cells is subject to ethical restrictions ; 4) The mechanism of stem cell therapy is not yet clear
Unfortunately, although this stem cell mobilization process exists, the repair effect produced is not enough to counteract the extensive cell death caused by myocardial infarction

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] 1-5nm, 5-10nm, 10-20nm, 20-30nm, 30-40nm, 40-50nm, 50-100nm, 100-1000nm iron particles are surface activated and modified by sodium oleate, polyethylene glycol, etc. The properties are then coated with dextran, liposomes, and nano-silica to make superparamagnetic iron powder (SPIO). The iron powder was mixed with CD117 and MLC in the Imject The targeted drug CD117-SPIO-MLC was obtained by coupling in EDC cross-linking buffer. The coupling efficiency measured by SDS page and A280 method is greater than 85%.

Embodiment 2

[0037] Buy Feraheme directly Particles (30nm particle size). The iron powder is mixed with CD117 and MLC in the Imject Coupling in EDC cross-linking buffer to obtain targeted drug CD117-Feraheme -MLC. The coupling efficiency measured by SDS page and A280 method is greater than 85%.

Embodiment 3

[0039] The iron particles of 1-5nm, 5-10nm, 10-20nm, 20-30nm, 30-40nm, 40-50nm, 50-100nm, 100-1000nm are surface activated and modified by sodium oleate, polyethylene glycol, etc. properties, and then coated with dextran, liposomes, and nano-silica to make superparamagnetic iron powder (SPIO). The iron powder was mixed with CD3 and CD68 in the Imject Coupling in EDC cross-linking buffer to obtain targeting contrast agent CD3-SPIO-CD68. The coupling efficiency measured by SDS page and A280 method is greater than 85%.

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Abstract

The invention discloses an antibody-based targeting medicine used for repairing damaged tissues. The medicine comprises stem cell specific antibodies and damaged part specific antibodies. The stem cell specific antibodies and damaged part specific antibodies are directly or simultaneously coupled on nano-grade or micron-grade iron particles through chemical covalent bonds. During an administration process employing the targeting medicine obtained by coupling the specific antibodies and the iron particles, and after the administration process, a lesion area can be covered by using an external magnetic field. The targeting medicine obtained by coupling the specific antibodies and the iron particles can also be used as an MRI contrast agent. The antibody-based targeting medicine used for repairing damaged tissues is safe and reliable. With the medicine, human body intrinsic stem cell reparation function can be optimized, and effector molecules can be delivered with targets. Therefore, a novel safe treatment means with advantages of high-efficiency reparation, no toxicity, and no side effect can be provided. With the external magnetic field, the targeting effect of the medicine can be improved, and side effect can be reduced. Also, the antibody-based targeting medicine used for repairing damaged tissues can actively identify cardiovascular lesions, such that the medicine can be used as an MRI contrast agent.

Description

technical field [0001] The invention relates to medicines, in particular to antibody-targeted medicines for repairing damaged tissues, administration methods and magnetic resonance contrast agents. Background technique [0002] Cardiovascular disease refers to a large group of diseases that affect the heart and blood vessels throughout the body. Depending on the part of the body affected, cardiovascular disease can be divided into coronary heart disease, cerebrovascular disease, and intermittent peripheral vascular disease. Cardiovascular disease is currently the world's number one health killer. According to a 2004 report by the World Health Organization (WHO), one in every three deaths is caused by cardiovascular disease. In China, the mortality rate of cardiovascular diseases is on the rise, and the number of deaths from cardiovascular diseases is about 3 million every year. [0003] Take myocardial infarction, for example, which is one of the largest causes of death i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/395A61K47/48A61K47/42A61K47/02A61K49/16A61P9/10
Inventor 程柯
Owner SUZHOU WANMUCHUN BIOLOGICAL TECH
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