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A kind of overall release Buyang Huanwu controlled sustained-release preparation and preparation method thereof

An overall release, controlled and sustained release technology, applied in the field of medicine, can solve the problems of the same difficult composition ratio, poor overall drug control, inconvenient slow and controlled release targets, etc., and achieve the effect of improving compliance

Active Publication Date: 2015-09-30
HUNAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] When using the overall skeleton drug delivery, if the drug and the matrix can be eroded (dissolved) from the outside to the inside at the same time, the drug can also reflect the synchronous and overall controlled release of the multi-components of the traditional Chinese medicine compound, but the matrix mostly needs water-soluble polymer materials. It is inconvenient to achieve the goal of sustained and controlled release; if the overall non-erodible matrix drug delivery system is used, the components will diffuse and dissolve from the matrix material. Because the diffusion coefficients of each component are different, it is difficult to be the same as the composition ratio required by the original decoction. Therefore, the drug Poor overall controllability
Therefore, this technology is not an ideal Chinese medicine compound multi-component controlled sustained-release drug delivery system;

Method used

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  • A kind of overall release Buyang Huanwu controlled sustained-release preparation and preparation method thereof
  • A kind of overall release Buyang Huanwu controlled sustained-release preparation and preparation method thereof
  • A kind of overall release Buyang Huanwu controlled sustained-release preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1 Preparation of Buyang Huanwu Quanfang Extract 1

[0047] Take Astragalus 60g. Angelica 9g, Chuanxiong 6g, Radix Paeoniae Rubra 9g, Peach Kernel 9g, Safflower 9g, Dilong 9g, extract with 8 times the amount of distilled water for about 2 hours, filter, add 8 times the amount of distilled water to the filter residue for secondary extraction for about 1 hour, filter, Combine the two filtrates, concentrate to obtain the extract of Buyang Huanwu Quan Fang, use 95% ethanol to precipitate, transition, filter, concentrate the filtrate, recover ethanol, and obtain the liquid extract of Buyang Huan Wu Quan Fang, which is dried to obtain Bu Yang Huan Five whole party extract1.

Embodiment 2

[0048] Example 2 Preparation of Buyang Huanwu Quanfang Extract 2

[0049] Get Astragalus 6kg. Angelica 0.9kg, Chuanxiong 0.6kg, Paeoniae Rubra 0.9kg, peach kernel 0.9kg, safflower 0.9kg, earthworm 0.9kg, extract with 20 times the amount of distilled water for about 3 hours, filter, add 15 times the amount of distilled water for secondary extraction For about 2 hours, filter, add 10 times the amount of distilled water to the filter residue for three extractions for about 1 hour, combine the three filtrates, concentrate to obtain the extract of Buyang Huanwu Quanfang, use 80% ethanol to precipitate, centrifuge, and the supernatant is at about 60 Concentrate under reduced pressure at ℃, and then dry in an oven at 70-75 ℃ to obtain Buyang Huanwu Quan Fang Extract 2.

Embodiment 3

[0050] Example 3 Preparation of Buyang Huanwu Quanfang Extract 3

[0051] The medicinal materials were weighed according to the following ratio: 60 parts of astragalus, 9 parts of angelica, 6 parts of Chuanxiong, 9 parts of red peony, 9 parts of peach kernel, 9 parts of safflower, and 9 parts of earthworm. Then extract with 15 times the amount of 50% ethanol solution for about 2 hours, filter, add 8 times the amount of 50% ethanol solution to the filter residue for secondary extraction for about 1.5 hours, filter, add 3 times the amount of 50% ethanol for three extractions for about 1 hour, Combine the three filtrates and concentrate in vacuum at 60°C to obtain the extract of Buyang Huanwu Quanfang. The relative density of the extract is 1.1-1.3; then use absolute ethanol precipitation for about 48 hours, and then reduce the pressure at 60°C Concentrate, and then vacuum-dry at 70-75°C to obtain Buyang Huanwu Quanfang extract 3.

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Abstract

The invention provides a preparation method for integrally controlling multiple components of the Yang recuperating controlled and sustained release preparation to release. Various types of controlled and sustained release preparations can be prepared by the controlled and sustained release preparation by utilizing osmotic pressure and membrane controlled release principles. The preparation method comprises the following steps of: adding starch, dextrin, water-soluble high-molecular polymer, hypertonic substances and other auxiliaries into the extract of the Yang recuperating prescription to prepare a tablet core; and coating the tablet core with the water-soluble polymer liquid containing a pore-forming agent, and poring to prepare an osmotic pump tablet; and preparing a microporous film coating tablet by adopting the high-molecular material and the pore-forming agent; and preparing controlled and sustained micropills, microspheres and small tablets by adopting the film controlled and sustained release material, or filling into hard capsule shells to prepare hard capsules. The invention also provides an integrally releasing Yang recuperating controlled and sustained release preparation, which can release multiple components of the drug in an integral and controlled way, so that the acting time of the medicament can be prolonged, the number of administration times can be reduced, and the compliance of clinical patient administration can be improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a controlled-sustained-release preparation of a compound traditional Chinese medicine, in particular to a multi-component medicine integral controlled-sustained-release preparation of a classic famous prescription Buyang Huanwu Decoction and a preparation method thereof. Background technique [0002] Buyang Huanwu Decoction was first recorded in "Yilin Gaicuo" by Wang Qingren in the Qing Dynasty. The whole prescription is composed of 60g astragalus, 9g angelica, 6g Chuanxiong, 9g red peony, 9g peach kernel, 9g safflower, and 9g earthworm. The function of collateral dredging, later research further showed that it has preventive and therapeutic effects in antithrombotic, antiaging, anticerebrovascular, antiblood lipid and regulating immune function, especially in acute ischemic stroke (cerebral infarction). It can play a good preventive and therapeutic role in the attack period, the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/22A61K9/52A61K9/28A61K9/44A61K36/73A61P9/10A61K35/62
Inventor 贺福元杨岩涛罗堃刘文龙石继连吴春英邓凯文罗杰英
Owner HUNAN UNIV OF CHINESE MEDICINE
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