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Chinese and western medicine compound emulsifiable paste for diminishing melanins and brightening and preparation method thereof

A compound cream, traditional Chinese and Western medicine technology, applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, ointment delivery, etc., can solve problems such as poor skin permeability, slow onset of action, and impact on curative effects, and achieve less adverse reactions and onset Fast and safe results

Inactive Publication Date: 2013-12-18
QINGDAO MUNICIPAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these traditional Chinese medicine prescriptions are mostly powders, which have slow onset of action, poor skin permeability during use, affect curative effect, and are inconvenient to use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 Minimum

[0029] 1. Raw materials and their weight: tranexamic acid, 25mg; licorice flavonoids, 10g; vitamin E, 30g; motherwort, 25g; castor oil, 50g; stearic acid, 50g; monoglyceride, 20g; liquid paraffin, 100g; Ethylparaben alcohol solution with a mass fraction of 10%, 5g; glycerin, 100g; purified water, 400g; essence, 2g.

[0030] Two, its preparation method is:

[0031] (1) Preparation of main ingredients

[0032] ①Weigh the tranexamic acid with the weight described in 1, dissolve it with 20g of purified water, and set aside;

[0033] ② Weigh the motherwort with the weight mentioned in 1, crush it to 80-100 mesh, soak in cold for 1 hour, add water to decoct for 4 hours according to the solid-to-liquid ratio of 1:25; the decoction liquid is concentrated until the remaining volume is 1 / 14-1 / 15, motherwort decoction, set aside;

[0034] (2) Preparation of excipients

[0035] 1. Weigh castor oil, liquid paraffin, stearic acid and monoglyceride respective...

Embodiment 2

[0045] 1. Raw materials and their weight: tranexamic acid, 30mg; licorice flavonoids, 12g; vitamin E, 40g; motherwort, 30g; castor oil, 60g; stearic acid, 60g; monoglyceride, 30g; liquid paraffin, 125g; Ethylparaben alcohol solution with a mass fraction of 10%, 10g; glycerin, 125g; purified water, 450g; essence, 3g.

[0046] All the other are with embodiment 1.

Embodiment 3

[0048] 1. Raw materials and their weight: tranexamic acid, 35mg; licorice flavonoids, 15g; vitamin E, 50g; motherwort, 35g; castor oil, 70g; stearic acid, 70g; Ethylparaben alcohol solution with a mass fraction of 10%, 15g; glycerin, 150g; purified water, 500g; essence, 4g.

[0049] All the other are with embodiment 1.

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PUM

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Abstract

The invention relates to a Chinese and western medicine compound emulsifiable paste for diminishing melanins and brightening and a preparation method of the Chinese and western medicine compound emulsifiable paste. The Chinese and western medicine compound emulsifiable paste is mainly composed of the following components in parts by weight: 25 to 35 parts of tranexamic acid, 10,000 to 15,000 parts of licoflavone, 30,000 to 50,000 parts of vitamin E, 25,000 to 35,000 parts of herba leonuri, 40,000 to 75,000 parts of castor oil, 40,000 to 70,000 parts of stearic acid, 20,000 to 40,000 parts of glycerol monostearate, 100,000 to 150,000 parts of liquid paraffin, 5,000 to 15,000 parts of 10% by mass fraction of ethylparaben alcohol solution, 100,000 to 150,000 parts of glycerol, 400,000 to 500,000 parts of pure water and the maintenance dose of essence. The preparation method comprises four steps, namely main material preparation, adjuvants preparation, emulsifiable paste preparation and quality inspection. The obtained cream is uniform and fine in components and easy to absorb, and the long-term clinical verifications show that the cream is safe and free from side effects and the effects on diminishing melanins and brightening are remarkable.

Description

technical field [0001] The invention relates to the field of pharmaceutical creams, in particular to a compound cream of Chinese and Western medicines for melanoma and brightening and a preparation method thereof. Background technique [0002] With the development of society, human beings are more pursuing the natural whitening of the skin, and do not want the skin to be coated with thick cosmetics. This provides a wide range of whitening agents for inhibiting melanin synthesis, brightening the skin tone, and achieving skin whitening effects. development prospects. Although there are many kinds of blackening and whitening products on the market, most of them are chemical ingredients, such as methoxyphenol, vitamin C, lead, mercury, etc. While it satisfies human pursuit of skin whitening, it also has some adverse effects on human skin or the whole body. For example, hydroquinone is a strong skin whitening agent, which can cause the increase of skin inflammatory pigmentation...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/533A61K9/06A61P17/00
Inventor 陈安进石杰张芳刘炳麟刘杰
Owner QINGDAO MUNICIPAL HOSPITAL
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