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Biomedical alpha-Ca (HPO4) x (SO4)1-x*1/2H2O solid solution particle and preparation method thereof

A technology of HPO42-, 2H2O, applied in chemical instruments and methods, prostheses, medical science, etc., to achieve the effect of simple operation, easy industrialization, improvement of injection performance and biodegradation performance

Inactive Publication Date: 2012-12-12
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these composite materials simply blend calcium sulfate and calcium phosphate, and use the different degradation rates of the two to adjust the degradation rate of the material, and do not change the material itself structurally, so that it has new characteristics to meet the needs of clinical applications.

Method used

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  • Biomedical alpha-Ca (HPO4) x (SO4)1-x*1/2H2O solid solution particle and preparation method thereof
  • Biomedical alpha-Ca (HPO4) x (SO4)1-x*1/2H2O solid solution particle and preparation method thereof
  • Biomedical alpha-Ca (HPO4) x (SO4)1-x*1/2H2O solid solution particle and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0022] 1) Add CaCl 2 and K 2 SO 4 Dissolved in deionized water, respectively prepared into solutions, mixed at room temperature according to the molar ratio of Ca / S of 1:1, the reaction was carried out under constant stirring, the reaction temperature was room temperature, and the reaction time was 2 hours. After the reaction, use Filter 3 times with deionized water, once with alcohol, and then dry at 60°C to obtain CaSO 4 2H 2 O;

[0023] 2) Dissolve 0.4g of citric acid monohydrate in 400ml of deionized water to make an electrolyte solution;

[0024] 3) 10g of CaSO obtained in step 1) 4 2H 2 0 and the electrolyte solution prepared in step 2) are mixed to obtain a suspension;

[0025] 4) Add 1g of CaHPO 4 2H 2 O and the suspension prepared in step 3) are stirred and mixed, then put into the reaction kettle, so that the molar ratio of P / S in the mixed solution is 0.1, and the reaction is carried out under the hydrothermal condition of 130°C, and the reaction time is 10...

Embodiment 2

[0027] 1) CaNO 3 and K 2 SO 4 Dissolved in deionized water, respectively prepared into solutions, mixed at room temperature according to the molar ratio of Ca / S of 1:1, the reaction was carried out under constant stirring, the reaction temperature was room temperature, and the reaction time was 2 hours. After the reaction, use Filter 3 times with deionized water, once with alcohol, and then dry at 60°C to obtain CaSO 4 2H 2 O;

[0028] 2) Dissolve 0.4g of citric acid monohydrate in 400ml of deionized water to make an electrolyte solution;

[0029] 3) 10g of CaSO obtained in step 1) 4 2H 2 0 and the electrolyte solution prepared in step 2) are mixed to obtain a suspension;

[0030] 4) Add 4.16g of Na 2 HPO 4 12H 2 O and the suspension prepared in step 3) are stirred and mixed, then put into the reaction kettle, so that the molar ratio of P / S in the mixed solution is 0.2, and the reaction is carried out under the hydrothermal condition of 140°C, and the reaction time i...

Embodiment 3

[0036] 1) Add CaCl 2 and Na 2 SO 4 Dissolved in deionized water, respectively prepared into solutions, mixed at room temperature according to the molar ratio of Ca / S of 1:1, the reaction was carried out under constant stirring, the reaction temperature was room temperature, and the reaction time was 2 hours. After the reaction, use Filter 3 times with deionized water, once with alcohol, and then dry at 60°C to obtain CaSO 4 2H 2 O;

[0037] 2) Dissolve 0.4g of citric acid monohydrate in 400ml of deionized water to make an electrolyte solution;

[0038] 3) 10g of CaSO obtained in step 1) 4 2H 2 0 and the electrolyte solution prepared in step 2) are mixed to obtain a suspension;

[0039] 4) Add 2.37g of KH 2 PO 4 Stir and mix the suspension prepared in step 3) and put it into the reaction kettle so that the molar ratio of P / S in the mixture is 0.3. The reaction is carried out under hydrothermal conditions at 150°C, and the reaction time is 6 hours. The reacted sample w...

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Abstract

The invention discloses a biomedical alpha-Ca (HPO4) x (SO4)1-x*1 / 2H2O solid solution particle and a preparation method thereof. By means of a wet-chemical method and heat treatment, parts of SO4 <2-> in CaSO4 are promoted to be replaced by HPO4<2-> to obtain the alpha-Ca (HPO4) x (SO4)1-x*1 / 2H2O solid solution particle, and compositions and proportions of the alpha- Ca (HPO4) x (SO4)1-x*1 / 2H2O solid solution particle can be adjusted. The prepared alpha-Ca (HPO4) x (SO4)1-x*1 / 2H2O solid solution particle can be widely used in the filed of biomedical materials of bone filling materials, bone cement and the like.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, in particular to an α-Ca(HPO 4 ) x (SO 4 ) 1-x 1 / 2H 2 Solid solution particles of O and its preparation method. Background technique [0002] Calcium sulfate has been used as an artificial bone repair material for hundreds of years, and its good biocompatibility, osteoconductivity, biodegradable absorbability and high compressive strength make it a research hotspot for inorganic bone repair materials And widely used in bone repair. [0003] Anhydrous CaSO 4 , CaSO 4 1 / 2H 2 O and CaSO 4 2H 2 O. The three can be transformed into each other under certain conditions. Anhydrous CaSO 4 It is mostly used as plaster bandages, handicrafts and construction materials. The medical calcium sulfate is mainly CaSO 4 1 / 2H 2 O and its hydrated CaSO 4 2H 2 O, and CaSO 4 2H 2 O is often used as a seed crystal to add to CaSO 4 1 / 2H 2 O, accelerated CaSO 4 1 / 2H 2 Hydration of O to...

Claims

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Application Information

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IPC IPC(8): C01B25/32C01F11/46A61L27/12A61L27/50A61L31/02A61L31/14
Inventor 程逵章华勇翁文剑黄海生
Owner ZHEJIANG UNIV
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