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Preparation method for CaO-SiO2/PAA composite film material having biological activity

A bioactive, composite membrane technology, applied in the field of preparation of CaO-SiO2/PAA composite membrane materials, can solve the problems of poor bone-like apatite formation ability, etc., and achieve the effect of good nanopore structure

Inactive Publication Date: 2014-07-02
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the research of Kokubo et al. confirmed that in the simulated body fluid, CaO-SiO 2 The base glass surface can form bone-like apatite, while CaO-P 2 o 5 Poor ability to induce bone-like apatite formation on glass-based surfaces

Method used

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  • Preparation method for CaO-SiO2/PAA composite film material having biological activity
  • Preparation method for CaO-SiO2/PAA composite film material having biological activity
  • Preparation method for CaO-SiO2/PAA composite film material having biological activity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] (1) Use nitric acid as a catalyst to prepare 1M TEOS aqueous solution; after TEOS is completely hydrolyzed, slowly drop 1M calcium hydroxide aqueous solution into TEOS, fully react for 1 hour under the action of a magnetic stirrer, and let stand until the solution forms a transparent Sol;

[0045] (2) Soak the 200nm PAA matrix in the sol; place the above solution containing the PAA matrix in a vacuum drying oven at room temperature for 3 hours; then take out the PAA matrix that has been vacuumed in the sol and put it in the muffle Heat treatment in the furnace at 550°C, the heating rate is 2°C / min, take it out after 8 hours of heat preservation. Washed three times with deionized water and dried for inspection.

[0046] (3) CaO-SiO before soaking sol and after soaking sol 2 / PAA composite film was characterized by SEM and EDS respectively, as shown in Figure 1~Figure 3 shown.

Embodiment 2

[0048] (1) Use nitric acid as a catalyst to prepare 1M TEOS aqueous solution; after TEOS is completely hydrolyzed, slowly drop 1M calcium nitrate aqueous solution into TEOS, fully react for 2 hours under the action of a magnetic stirrer, and stand until the solution forms a transparent sol ;

[0049] (2) Soak the 100nm PAA matrix in the sol; put the solution containing the PAA matrix in a vacuum drying oven at room temperature for 2 hours; then take out the PAA matrix that has been vacuumed in the sol, and put it in the muffle Heat treatment in the furnace at 500°C with a heating rate of 3°C / min, keep it warm for 6 hours and take it out. Wash three times with deionized water and dry.

[0050] (3) CaO-SiO 2 The / PAA composite membrane was soaked in the prepared SBF solution for 1 day and 7 days, then it was taken out, washed twice with deionized water, and dried at room temperature for inspection.

[0051] (4) CaO-SiO after soaking SBF solution for 1 day and 7 days 2 / PAA c...

Embodiment 3

[0053] (1) Use nitric acid as a catalyst to prepare 1M TEOS aqueous solution; after TEOS is completely hydrolyzed, slowly drop 1M calcium acetate aqueous solution into TEOS, fully react for 1 hour under the action of a magnetic stirrer, and let stand until the solution forms a transparent sol ;

[0054] (2) Soak the 75nm PAA matrix in the sol; put the solution containing the PAA matrix in a vacuum drying oven at room temperature for 1 hour; then take out the PAA matrix that has been vacuumed in the sol and put it in the muffle Heat treatment in the furnace at 450°C with a heating rate of 1°C / min, take it out after 4 hours of heat preservation. Wash three times with deionized water and dry.

[0055] (3) CaO-SiO 2 The / PAA composite membrane was soaked in the prepared SBF solution for 1 day, taken out, washed twice with deionized water, and dried at room temperature for inspection.

[0056] (4) CaO-SiO after soaking SBF solution for 1 day 2 / PAA composite films were characte...

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Abstract

The invention relates to a preparation method for a CaO-SiO2 / PAA (porous anodic alumina) composite film material having biological activities. The invention uses a sol-gel method to synthesize a binary system of silicate sol, and takes PAA as a matrix. The PAA matrix is placed in the sol. The sol is vacuumized for 1-3 hours. The PAA matrix is finally heated to get the CaO-SiO2 / PAA composite film. The composite film material obtained from the invention has a special nanopore structure and good biological activities. Experiments in vitro show that bone-like apatite is generated on the surface of the composite film soaked in a simulated body fluid (SBF) for a day. So, the preparation method is rapid, simple, efficient and suitable for the surface function modified design of biological materials.

Description

technical field [0001] The invention belongs to the field of preparation of calcium-silicon-based biomaterials, in particular to a bioactive CaO-SiO 2 The preparation method of / PAA composite film material. Background technique [0002] Porous anodic alumina (PAA) thin film materials have attracted extensive attention of researchers due to their important applications in the preparation of nanostructured materials. PAA has many excellent characteristics, such as good surface chemical stability, stable mechanical properties and not easy to degrade. At the same time, the distribution of micro-nano channels in PAA is highly ordered, and the columnar channels are parallel to each other, which is almost a hexagonal close-packed periodic structure. In recent years, PAA has also been partially reported as a biomedical material. Hoess et al. (Acta Biomaterialia, 2007, 3:43~50) have proved that PAA has good biocompatibility, can well promote the adhesion and proliferation of liver...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/42A61L27/56A61L27/52
Inventor 倪似愚项兴李晓宏吴培
Owner DONGHUA UNIV
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