Purification method for two active monomer compounds in saxifrage and application of product of the same
A technology of active monomers and saxifrage, applied in chemical instruments and methods, organic active ingredients, medical preparations containing active ingredients, etc., can solve the problems of undiscovered active ingredients
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Embodiment 1
[0063] Embodiment 1 of the present invention: the preparation of saxifrage extract:
[0064] Take the dried saxifrage whole herb, crush it into a coarse powder, add 8 times the volume of 80% ethanol to reflux extraction twice, each time for 2 hours, filter, combine the filtrate, recover ethanol under reduced pressure, and concentrate the remaining liquid to a relative density of 1.25 thick paste, that is, saxifrage extract Ⅰ.
Embodiment 2
[0065] Embodiment 2 of the present invention: preparation of saxifrage extract:
[0066] Take the dried saxifrage whole herb, crush it into a coarse powder, add 8 times the volume of 80% ethanol to reflux extraction twice, each time for 2 hours, filter, combine the filtrate, recover ethanol under reduced pressure, and concentrate the remaining liquid to a relative density of The thick paste of 1.25 was extracted twice with 4 volumes of petroleum ether and ethyl acetate respectively, and the ethyl acetate extracts were combined and evaporated to dryness under reduced pressure to obtain the saxifrage extract II.
Embodiment 3
[0067] Embodiment 3 of the present invention: Extraction and purification of two active monomer compounds in saxifrage:
[0068] (1) Take the dried saxifrage whole herb, crush it into a coarse powder, add 8 times the volume of 80% ethanol to reflux and extract twice, each time for 2 hours, filter, combine the filtrates, recover ethanol under reduced pressure, and concentrate the remaining liquid to Relative density is the thick ointment of 1.25, obtains Saxifraga ethanol extract;
[0069] (2) The ethanol extract of saxifrage was extracted twice with 4 times the volume of petroleum ether and ethyl acetate in sequence, and the ethyl acetate extract was combined, and evaporated to dryness under reduced pressure to obtain the ethyl acetate extract;
[0070](3) The ethyl acetate extract was segmented using 200-300 mesh column chromatography silica gel, and gradient eluted with petroleum ether: ethyl acetate = 30:1-1:1 and chloroform: methanol = 30:1-0:1; The highly polar part of e...
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