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Compound paracetamol injection and preparation method thereof

A technology of acetaminophen and injection, applied in the direction of medical formulas, medical preparations containing active ingredients, organic active ingredients, etc., can solve problems such as improper medication, aggravating the burden of liver detoxification, and difficulty in long-term use, and achieve a cure rate high effect

Active Publication Date: 2012-10-31
山东中牧兽药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term, large-scale, and complex addition of antibiotics to prevent pig diseases will cause pigs to develop drug resistance, increase the burden of liver and kidney detoxification, and damage the normal functions of the liver, kidneys and gastrointestinal tract, thereby reducing the ability of pigs to resist diseases
Second, inappropriate medication in the treatment
[0005] At present, there are a variety of drugs for the treatment of pig hyperthermia on the market, which have achieved certain therapeutic effects, but because the disease is prone to drug resistance, it is not easy to use a drug for a long time

Method used

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  • Compound paracetamol injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Formulation Example 1 Preparation of 10 L Compound Paracetamol Injection

[0028] prescription:

[0029] Acetaminophen 0.2kg,

[0030] Aminophylline 0.1kg,

[0031] Gentamicin sulfate 0.1kg,

[0032] Propylene Glycol 2L,

[0033] Ethanol 2L,

[0034] Sodium thiosulfate 0.01kg,

[0035]EDTA0.001kg,

[0036] The balance is water for injection.

[0037] Preparation:

[0038] Step 1: Heat the mixture of 2L ethanol and 2L propylene glycol to 50 degrees Celsius, add 0.2kg of acetaminophen and stir to dissolve for 15 minutes; then add 0.001kg of EDTA, stir and dissolve for 5 minutes;

[0039] Step 2: 0.1kg of gentamicin sulfate was added to 1L of water for injection, stirred and dissolved for 5 minutes to obtain a gentamicin sulfate solution;

[0040] Step 3: After stirring and dissolving 0.1kg of aminophylline and 2L of water for injection for 10 minutes, add 0.01kg of sodium thiosulfate and stir and dissolve for 10 minutes;

[0041] Step 4: Add the solution obtain...

Embodiment 2

[0043] Formulation Example 2 Preparation of 10 L Compound Paracetamol Injection

[0044] prescription:

[0045] Acetaminophen 1kg,

[0046] Aminophylline 0.1kg,

[0047] Gentamicin sulfate 0.05kg,

[0048] Propylene Glycol 3L,

[0049] Ethanol 2L,

[0050] Sodium thiosulfate 0.02kg,

[0051] EDTA0.002kg,

[0052] The balance is water for injection.

[0053] Preparation:

[0054] Step 1: Heat the mixture of 2L ethanol and 3L propylene glycol to 50 degrees Celsius, add 1kg of acetaminophen and stir to dissolve for 30min; then add 0.002kg of EDTA, stir to dissolve for 10min;

[0055] Step 2: Add 0.05kg of gentamicin sulfate to 1L of water for injection, stir and dissolve for 10 minutes to obtain a gentamicin sulfate solution;

[0056] Step 3: After stirring and dissolving 0.1kg of aminophylline and 1L of water for injection for 30 minutes, add 0.02kg of sodium thiosulfate and stir and dissolve for 10 minutes;

[0057] Step 4: Add the solution obtained in Step 2 and St...

Embodiment 3

[0059] Formulation Example 3 Preparation of 10 L Compound Paracetamol Injection

[0060] prescription:

[0061] Paracetamol 0.6kg,

[0062] Aminophylline 0.04kg,

[0063] Gentamicin sulfate 0.08kg,

[0064] Propylene Glycol 3.5L,

[0065] Ethanol 2.5L,

[0066] Sodium thiosulfate 0.02kg,

[0067] EDTA0.001kg,

[0068] The balance is water for injection.

[0069] Preparation:

[0070] Step 1: Heat the mixture of 2.5L ethanol and 3.5L propylene glycol to 60 degrees Celsius, add 0.6kg of acetaminophen and stir to dissolve for 15 minutes; then add 0.001kg of EDTA, stir and dissolve for 8 minutes;

[0071] Step 2: 0.08kg of gentamicin sulfate was added to 1.5L of water for injection, stirred and dissolved for 15 minutes to obtain a gentamicin sulfate solution;

[0072] Step 3: After stirring and dissolving 0.04kg of aminophylline and 1L of water for injection for 15 minutes, add 0.02kg of sodium thiosulfate and stir and dissolve for 7 minutes;

[0073] Step 4: Add the s...

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Abstract

The invention discloses compound paracetamol injection and relates to the field of veterinary medicine preparation. The compound paracetamol injection is prepared from paracetamol, aminophylline, gentamicin sulphate, propylene glycol, alcohol, an antioxidant, EDTA (Ethylene Diamine Tetraacetic Acid) and water for injection. The invention also provides a preparation method of the compound paracetamol injection. As a novel veterinary compound preparation, the compound florfenicol injection has the characteristics of strong synergistic effect and low dosage, can effectively treat porcine hyperthermia and has the important significance for sustainable development of the animal husbandry.

Description

technical field [0001] The invention relates to the field of veterinary drug preparations, in particular to a compound acetaminophen injection. Background technique [0002] Pig high fever is also known as pig unknown high fever, high fever syndrome, etc. The morbidity and mortality are very high, and many conventional treatment methods are difficult to see the ideal curative effect, resulting in large-scale death of pigs in many pig farms and heavy losses, and many small and medium-sized pig farms are closed because of this. Pig hyperthermia spreads quickly and is prevalent in local areas. Pigs of all ages can be infected, but it occurs frequently in pigs weighing more than 20 kg, especially in small and medium-sized pig farms and scattered farmers with high stocking density and irregular management. The morbidity and mortality are high. High, the treatment is difficult to be effective. Clinical symptoms: Pig hyperthermia in different regions or different pig farms often ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7036A61K9/08A61P29/00A61K31/167A61K31/522
Inventor 王统高
Owner 山东中牧兽药有限公司
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