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Sustained release micro-pellet of guaifenesin and preparation process thereof

A technology of guaiacol glycerol ether and sustained-release pellets, which can be applied to ether/acetal active ingredients, bulk delivery, respiratory diseases, etc., can solve problems such as affecting drug release mode, and achieve process reproduction Good performance, stable and reliable effect of drug release mode

Inactive Publication Date: 2007-07-11
SHANGHAI INST OF PHARMA IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this way, the uniformity of mixing will be a problem, which will inevitably affect the release mode in vivo

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Pill Loaded Prescription:

[0029] Guaifenesin 180g

[0030] Microcrystalline Cellulose 20g

[0031] Extended Release Coating Prescription:

[0032] Surelease 80g

[0033] Hydroxypropyl Methyl Cellulose 4g

[0034] Immediate Release Coating Prescription:

[0035] Guaifenesin 45g

[0036] Hydroxypropyl Methyl Cellulose 4.5g (10%)

[0037] I. Preparation of drug-loaded pellet cores by extrusion and spheronization to prepare drug-loaded pellet cores

[0038] (1) According to the prescription quantity, mix the microcrystalline cellulose and guaiacol glycerin evenly, and add water to make a plastic soft material.

[0039] (2) The soft material is extruded and rounded by the extrusion and rounding device. Process: Extrusion speed is about 75rpm, spheronization speed is 900-1000rpm, and then dried at 60°C, screened and coated with 16-24 mesh loaded pill core.

[0040] II. Sustained-release coating process: use a fluidized bed device to coat the sustained-release coating...

Embodiment 2

[0048] Pill Loaded Prescription:

[0049] Guaifenesin 100g

[0050] Microcrystalline Cellulose 96g

[0051] Povidone 4g

[0052] Extended Release Coating Prescription:

[0053] Surelease 16g

[0054] Immediate Release Coating Prescription:

[0055] Guaifenesin 25g

[0056] Povidone 2.5g

[0057] The preparation process is as in Example 1.

Embodiment 3

[0059] Pill Loaded Prescription:

[0060] Guaifenesin 160g

[0061] Microcrystalline Cellulose 38g

[0062] Sodium Carboxymethyl Cellulose 2g

[0063] Extended Release Coating Prescription:

[0064] Surelease 32g

[0065] Hydroxypropyl methylcellulose 0.8g

[0066] Immediate Release Coating Prescription:

[0067] Guaifenesin 17.8g

[0068] Hydroxypropyl Cellulose 1.78g

[0069] The preparation process is as in Example 1.

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PUM

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Abstract

The invention relates to a method for producing lignan slow-release micro drop and relative preparation, wherein it comprises active component, and carrier element, slow-release package and quick-release drug layer. The invention uses round technique to prepare high-carrier drug element to be packed and coated with quick-release layer; the slow-release layer uses cellulose ethyl ether; package is processed at fluid condition. The invention can release drug for 12h.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to guaiacol glycerin sustained-release pellets capable of sustained release for 12 hours and a preparation method thereof. Background technique [0002] The main source of sputum is secretion from tracheobronchial glands and goblet cells. In pathological conditions such as respiratory inflammation, mucus cannot be transported out in time due to excessive secretion due to inflammatory stimulation, or decreased cilia activity due to mucosal epithelial lesions, or pathological changes in sputum components that increase viscosity. A large amount of sputum obstructing the airway can cause shortness of breath and even suffocation. On the other hand, sputum is a good culture medium, which is conducive to the growth of pathogens and cause secondary infections. Therefore, expectorant discharge is one of the important symptomatic treatment measures. [0003] Guaifenesin is one of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/09A61K9/16A61P11/10
Inventor 陈庆华熊龙启包泳初潘峰瞿挺
Owner SHANGHAI INST OF PHARMA IND CO LTD
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