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Hollow capsule and its preparation method and application

A hollow capsule and inulin technology, applied in the direction of capsule transportation, can solve the problems of quality and safety hazards, and achieve the effects of low cost, stable structure and guaranteed stability.

Inactive Publication Date: 2012-10-24
YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Traditional hollow capsules have gradually exposed some quality and safety hazards, such as the poisonous capsule incident exposed in April 2012: using quicklime to process leather waste and boil it into industrial gelatin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Dosing: Dosing according to the mass percentage concentration of 5% inulin, 1% sodium alginate, 2% glycerin, 3% calcium chloride, and the balance is water, and then stir evenly.

[0026] (2) Water bath: Put the prepared solution in a 60°C constant temperature water bath and heat and stir until it becomes a lump-free glue.

[0027] (3) Constant temperature degassing: at a constant temperature of 25°C, use the static degassing method for 24 hours.

[0028] (4) Dip in glue: Gently shake and shake the above solution after standing still. Then measure 2ml of the glue liquid and pour it into the large mold, and measure 1.5ml of the glue liquid and pour it into the small mold.

[0029] (5) Drying: Put the mold in an oven at 60°C for 20 hours, and dry the glue until the film appears.

[0030] (6) Demoulding, cutting, fitting, checking, and packaging to obtain the finished hollow capsule.

Embodiment 2

[0032] (1) Dosing: Dosing according to the mass percentage concentration of 10% inulin, 1% sodium alginate, 2% glycerin, 3% calcium chloride, and the balance is water, and then stir evenly.

[0033] (2) Water bath: Put the prepared solution in a 60°C constant temperature water bath and heat and stir until it becomes a lump-free glue.

[0034] (3) Constant temperature degassing: at a constant temperature of 25°C, use the static degassing method for 24 hours.

[0035] (4) Dip in glue: Shake the solution gently and shake it evenly. Then measure 2ml of the glue liquid and pour it into the large mold, and measure 1.5ml of the glue liquid and pour it into the small mold.

[0036] (5) Drying: Put the mold in an oven at 60°C for 20 hours, and dry the glue until the film appears.

[0037] (6) Demoulding, cutting, fitting, checking, and packaging to obtain the finished hollow capsule.

Embodiment 3

[0039] (1) Dosing: Dosing according to the mass percentage concentration of 5% inulin, 3% sodium alginate, 2% glycerin, 3% calcium chloride, and the balance is water, and then stir evenly.

[0040] (2) Water bath: Put the prepared solution in a 60°C constant temperature water bath and heat and stir until it becomes a lump-free glue.

[0041] (3) Constant temperature degassing: at a constant temperature of 25°C, use the static degassing method for 24 hours.

[0042] (4) Dip in glue: Shake the solution gently and shake it evenly. Then measure 2ml of the glue liquid and pour it into the large mold, and measure 1.5ml of the glue liquid and pour it into the small mold.

[0043] (5) Drying: Put the mold in an oven at 60°C for 20 hours, and dry the glue until the film appears.

[0044] (6) Demoulding, cutting, fitting, checking, and packaging to obtain the finished hollow capsule.

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PUM

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Abstract

The invention relates to an excipient used for medicinal preparation, concretely relates to a hollow capsule and its preparation method and application. The hollow capsule comprises, on a mass basis, 5-50% of inulin, 1-3% of a film forming agent, 2-5% of a plasticizer (ie, curing agent), 2-5% of a cross-linking agent (ie. coagulant), and the balance water. The capsule provided by the invention has the characteristics of good smooth shape, edibility, health care, and so on. The base material inulin itself is water-soluble meal fiber, which can provide certain nutrition to microbes in human guts, being stable in property and difficult to react with the medicine enclosed. The inulin hollow capsule is applicable for various populations, has good stability and is convenient for long time storage. Moreover, the process flow is simple, and the equipment can also be used for the production of gelatin capsule, saving production cost of the inulin capsule. And the indexes such as collapse time limit, and the breakage at different temperatures of the capsule are all meet the national standard of hollow capsules.

Description

technical field [0001] The invention relates to an auxiliary material used in pharmaceutical preparations, in particular to a hollow capsule and its preparation method and application. Background technique [0002] Hollow capsules are the main excipients for processing pharmaceutical capsule preparations. At present, the main component of hollow capsules is soft gelatin. The production process is mainly to use gelatin extracted from animal skin and bone, and add certain plasticizers (ie curing agents), cross-linking agents (ie coagulants), Food pigments and opacifiers are used to make gelatin liquid, and then made by mold dipping, solidification, drying, cutting and other processes. Such gelatin-produced capsules are vulnerable to environmental changes after being filled with drugs because the gelatin contains animal protein. Practice has proved that gelatin capsules will deform under high temperature or high humidity conditions; but under dry conditions, the capsules will...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/36
Inventor 李莉莉秦松王绍宇刘冰王义鹏焦旭栋
Owner YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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