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Method for synthesizing ethenzamide

A synthesis method and a technique for disalicylamine are applied in the field of synthesis of disalicylamine (2-ethoxybenzamide) to achieve the effects of reduced synthesis operation time, improved yield and reduced synthesis cost

Inactive Publication Date: 2012-09-19
自贡鸿鹤化工股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But this method needs to use 95% alcohol as the reaction medium, and needs to use 50% ethanol solution as the solvent during purification

Method used

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  • Method for synthesizing ethenzamide
  • Method for synthesizing ethenzamide
  • Method for synthesizing ethenzamide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Press synthetic method of the present invention, drop into 100kg salicylamide (raw material purity 99%), 45kg sodium hydroxide (caustic caustica), 80kg diethyl sulfate (raw material purity 98%). Produce the former powder of 68kg ethyl salicylamine by the inventive method, compare product is ethyl salicylamine through infrared spectrometer, measure the purity 98.1% of ethyl salicylamine with ultraviolet spectrophotometer, reach 2006 edition " national drug standard ".

Embodiment 2

[0028] Press synthetic method of the present invention, drop into 2000kg salicylamide, 900kg sodium hydroxide (caustic caustica), 1610kg diethyl sulfate. Output 1110kg medicinal ethyl salicylamine raw powder, the product compared by infrared spectrometer is ethyl salicylamine, and the purity measured by ultraviolet spectrophotometer is 98.1%, reaching the 2006 edition of "National Drug Standard".

Embodiment 3

[0030] According to the production method of the present invention, drop into 2000kg salicylamide, 920kg sodium hydroxide (caustic soda), 1610kg diethyl sulfate, produce 1090kg medicinal ethyl salicylamine former powder altogether, compare product through infrared spectrometer to be ethyl salicylamine , the purity measured by ultraviolet spectrophotometer is 98.1%, reaching the 2006 edition of "National Drug Standards".

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Abstract

The invention provides a novel method for synthesizing ethenzamide. In the method, salicylamide and ethylsulfate serve as raw materials and are subjected to reaction to synthesize the ethenzamide in a sodium hydroxide solution. Accordingly, organic solvents are not adopted, synthesizing steps are simple, the yield is high, the index of ethenzamide products reaches 'national drug standard' of 2006 edition, and the method is suitable for drug production.

Description

technical field [0001] The invention relates to a method for synthesizing ethyl salicylamine (2-ethoxybenzamide). Background technique [0002] Ethylamine, also known as o-ethoxybenzamide, is the main raw material for the manufacture of Ethylamine tablets. It has anti-inflammatory, antipyretic, and analgesic effects. It has the characteristics of small intestinal stimulation side effects and remarkable curative effect. [0003] Since the end of the 1960s, the synthesis methods of ethyl salicylamine reported in domestic literature include: "Synthesis of o-ethoxybenzamide" [Chi Wenshou, Pharmaceutical Industry, 1982, (09), 5] and "Synthesis of o-ethoxybenzamide by phase transfer catalysis" [Zhong Qi, Shao Jianguo, Pharmaceutical Industry, 1984, (09), 39]. The synthetic methods of the two reports all use salicylic acid as the basic raw material to synthesize o-ethoxybenzamide. There are many kinds of materials used in the synthesis process, and organic solvents or catalysts ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C235/46C07C231/12
Inventor 杨小川
Owner 自贡鸿鹤化工股份有限公司
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