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Method for reducing incidence of in-stent restenosis and special stainless steel material thereof

A stent material, stainless steel technology, applied in stents, medical science, surgery, etc., can solve the problem of appropriate dose half-life, achieve the effect of reducing restenosis in the stent and the incidence of restenosis

Active Publication Date: 2012-08-01
蔻沛斯蒂(浙江)医疗器械有限公司
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Problems solved by technology

Surface-modified stents such as gene coating and endothelialization treatment are still in the research stage, and there are still problems such as whether the dose of radiochemically treated stents is controllable and whether the half-life is appropriate

Method used

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  • Method for reducing incidence of in-stent restenosis and special stainless steel material thereof
  • Method for reducing incidence of in-stent restenosis and special stainless steel material thereof
  • Method for reducing incidence of in-stent restenosis and special stainless steel material thereof

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Experimental program
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Effect test

Embodiment

[0022] Table 1 Chemical composition of 316L type copper-containing stainless steel (weight%)

[0023]

[0024] Flow Cytometry:

[0025] The apoptosis rate of 316L copper-containing stainless steel on endothelial cells (HUVEC) and vascular smooth muscle cells (VSCMs) was measured by flow cytometry. This method can objectively evaluate the effect of copper-containing stainless steel on the proliferation of HUVEC and VSCMs. First prepare the extract, according to 3cm 2 Add the culture solution containing 10% fetal bovine serum at a ratio of / mL, immerse the stainless steel sample in the culture solution, and then let it stand in a place containing 5% CO 2 Store in an incubator at 37°C and 95% humidity, and collect the precipitate after 96 h. The cells tending to confluence were collected, resuspended by blowing and blowing with 0.25% trypsin-containing culture medium, and the resuspended cells were plated in five 6-well plates, one plate for each group. After 24 hours, the ...

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Abstract

The invention relates to the field of coronary stents, specifically to a method for reducing the incidence of in-stent restenosis and its special stainless steel material. The method of the invention adds a proper amount of copper element (2.0-6.0% by weight) into the common clinical coronary stent material 316L stainless steel, and conducts special heat treatment so as to make the copper separated in a copper-rich phase out of the stainless steel substrate. The stent is enabled to continuously release trace amounts of copper ions in a clinical environment, and the coronary stent is endowed with an anti-restenotic function, thus effectively reducing the incidence of restenosis after stent implantation. With a unique function of reducing the in-stent restenosis phenomenon caused by stent implantation into a coronary artery, the 316L type copper-containing stainless steel of the invention is conducive to solve clinical problems such as high incidence of in-stent restenosis after implantation of existing stainless steel coronary stents, and can be applied in coronary stents and other clinical medicine fields, thus providing a new idea and material basis for development and application of coronary stents.

Description

technical field [0001] The present invention relates to the field of coronary artery stents, in particular to a method for effectively reducing the incidence of in-stent restenosis and a new 316L type copper-containing stainless steel material for special coronary artery stents, which has the ability to effectively reduce the occurrence of stents after implantation of stainless steel coronary artery stents The unique function of internal restenosis can be applied in medical clinical fields such as coronary artery stent implantation. Background technique [0002] Heart disease is one of the primary causes of human health threats, and now about 15 million patients with coronary heart disease worldwide need advanced percutaneous transluminal coronary angioplasty (PTCA). PTCA has the advantages of minimal trauma, high efficiency and easy repeatability, so it has become a rapidly developing new method for the treatment of coronary heart disease caused by cardiovascular stenosis. ...

Claims

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Application Information

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IPC IPC(8): C22C38/44C22C38/42A61L31/02A61L31/14A61F2/82
Inventor 任玲杨柯
Owner 蔻沛斯蒂(浙江)医疗器械有限公司
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