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Method for extracting curcumin from turmeric

A technology for curcumin and turmeric, which is applied in the field of preparation and purification of natural compounds, can solve the problems of difficult large-scale industrial production, low curcumin yield and the like, and achieves the effects of less solvent consumption, high extraction rate, and short separation and purification process flow.

Active Publication Date: 2012-08-01
宁波中药制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This preparation method will not only bring a variety of solvent residues into the product, but also lack attention to the problem of heavy metal residues, and there are problems such as low curcumin yield and difficulty in large-scale industrial production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] a. Extraction: turmeric is washed, dried, and crushed into 20-40 mesh turmeric powder. Weigh 5.0 kilograms of turmeric powder, mix it with 30 liters of 80% methanol aqueous solution and stir to make it evenly mixed, then reflux extraction at 75° C. for 2 hours, and reflux extraction twice. Combine the extracts obtained by two reflux extractions, filter and separate, remove the residue, concentrate the filtrate under reduced pressure at -0.07Mpa, 60°C, add 2.0-2.5L of water to control the degree of concentration to no methanol, recover methanol, and obtain a concentrate.

[0026] b. Separation and removal of heavy metals: Cool the remaining concentrated solution to room temperature and place it until it is fully precipitated; separate the supernatant liquid and discard it; add 2.0L of water to the precipitate, heat to 60°C, stir and disperse Afterwards, cool to room temperature, and place until fully precipitated; separate the supernatant liquid, and discard the clarifie...

Embodiment 2

[0029] a. Extraction: turmeric is washed, dried, crushed into 20-40 mesh turmeric powder, weighed 10.0 kg, mixed with 70 liters of turmeric powder and 75% ethanol aqueous solution, stirred to make it evenly mixed, and then mixed at 80°C Reflux extraction for 2 hours, a total of 3 extractions; the extracts were combined, filtered, separated, and residues were removed, the filtrate was concentrated under reduced pressure at 0.095Mpa and 60°C, and 4.0-5.0L of water was added to control the concentration to no ethanol, and ethanol was recovered;

[0030] b. Separation and removal of heavy metals: Cool the remaining concentrated solution to room temperature and place it until it is fully precipitated; separate the supernatant liquid and discard it; add 4.0L of water to the precipitate, heat to 70°C, stir and disperse After that, cool to room temperature, and place until fully precipitated; separate the supernatant liquid, and discard the clarified liquid;

[0031] c. Separation and...

Embodiment 3

[0034] a. Extraction: turmeric is cleaned, dried, crushed into 20-40 purpose turmeric powder, weighs 5.0 kg, turmeric powder and 40 liters of concentration are 70% acetone aqueous solution by weight / volume ratio 1: 8 mix, at 85 Stirring and reflux extraction at ℃ for 1.5 hours, a total of 2 extractions; the extracts were combined, filtered, separated, and residues were removed, the filtrate was concentrated under reduced pressure at 0.05Mpa and 60 ℃, and 1.0L of water was added to control the concentration until no acetone was recovered. acetone;

[0035] b. Separation and removal of heavy metals: Cool the remaining concentrated solution to room temperature and place it until it is fully precipitated; separate the supernatant liquid and discard it; add 2.5L of water to the precipitate, heat to 85°C, stir and disperse After that, cool to room temperature, and place until fully precipitated; separate the supernatant liquid, and discard the clarified liquid;

[0036] c. Separati...

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Abstract

The invention relates to a method for extracting curcumin from turmeric. The method is characterized by comprising the following steps that: the turmeric is cleanly cleaned and is then crushed into turmeric powder, the turmeric powder and extraction solvents are mixed according to a certain proportion and are then subjected to backflow extraction, next, the separation is carried out under certain conditions to remove heavy metals, and finally, the precipitates are separated and crystallized to obtain curcumin. Compared with the prior art, the method has the advantages that the heavy metal separation and purification flow process is simple and short, the risk of secondary pollution caused by the additional addition of absorption agents or absorption media is avoided, and the heavy metal residue of products can be purified to a degree that the lead content is lower than 1.0PPM, the cadmium content is lower than 1.0 PPM, the mercury content is lower than 0.10 PPM, and the arsenic content is lower than 0.10PPM.

Description

technical field [0001] The invention relates to the preparation and purification of natural compounds, in particular to a method for extracting curcumin with high content and low heavy metal residues from turmeric raw materials. Background technique [0002] Curcumin is a diketone phenolic pigment extracted from the rhizome of Turmeric, a plant of the genus Curcuma longa in the family Zingiberaceae. It is an orange-yellow crystalline powder with a slightly bitter taste. Its color is stable and its toxicity is very low. Medical research shows that curcumin has the effects of lowering blood fat, anti-tumor, anti-inflammatory, choleretic, and anti-oxidation. At present, it has been widely used in food, medicine, health products, cosmetics and dyes. [0003] At present, heavy metal residues in active extracts such as natural medicines, health products and health food additives extracted from plants have become the focus of attention at home and abroad. The research on heavy met...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C49/255C07C45/79C07C45/78
Inventor 金绍生赵丽娟方明左海兵李亚超
Owner 宁波中药制药股份有限公司
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