Method for preparing water-soluble manganese oxide magnetic resonance contrast agent and application thereof

A magnetic resonance contrast agent, manganese oxide technology, applied in the direction of emulsion delivery, drug delivery, etc., can solve the problems of small difference in signal intensity, failure to reach diagnosis, etc., and achieve the goal of improving contrast, reducing toxicity, and shortening relaxation time Effect

Inactive Publication Date: 2012-08-01
SHANGHAI NORMAL UNIVERSITY
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  • Abstract
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  • Claims
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Problems solved by technology

Although MRI has many of the above advantages, a large number of clinical cases have shown that there is often little difference in signal intensity between benign and malignant tumor tissues and normal tissues, which cannot achieve the purpose of diagnosis

Method used

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  • Method for preparing water-soluble manganese oxide magnetic resonance contrast agent and application thereof
  • Method for preparing water-soluble manganese oxide magnetic resonance contrast agent and application thereof
  • Method for preparing water-soluble manganese oxide magnetic resonance contrast agent and application thereof

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Embodiment Construction

[0027] The technical characteristics of the present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.

[0028] 1. Experimental Drugs

[0029] Sodium Oleate, Oleic Acid, Octadecene, Cetyltrimethylammonium Bromide (CTAB), Chloroform, Sodium Polyphenylsulfonate (PSS), Polyvinylpyrrolidone (PVP)

[0030] Two, the preparation of manganese oleate

[0031] Add 7.5-8g of manganese chloride and 24.0-24.5g of sodium oleate into a mixture consisting of 140mL of ethanol, water and n-hexanol, and stir overnight at 70°C. The obtained solution was transferred to a separatory funnel, washed several times with deionized water to obtain a dark red organic matter in the upper layer, which was transferred to a flask, and n-hexanol was distilled off to obtain a dark red manganese oleate solid.

[0032] 3. Preparation of oily manganese oxide

[0033] Weigh 1-1.5g of manganese oleate solid and place it in a three-necked flask, add 10...

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Abstract

The invention discloses a method for preparing a water-soluble manganese oxide magnetic resonance contrast agent and application thereof, which is a superparamagnetic water-soluble manganese oxide magnetic resonance contrast agent. Firstly, manganese oleate and octadecene are mixed evenly to prepare superparamagnetic oily manganese oxide nano particles through a high temperature thermal decomposition mothod, then oil-soluble manganese oxide is converted into water-soluble manganese oxide through oil-water phase inversion, and finally the water-soluble manganese oxide is wrapped by a surface polymer to prepare water-soluble manganese oxide nano particles. The water-soluble manganese oxide nano particles serving as a novel nuclear magnetic resonance contrast agent are transfected to K652 cancer cells cultured in vitro, thereby showing the enhancement of magnatic resonance imaging (MRI) effect. By means of intravenous injection to a mouse tail, the MRI effect is analyzed, and good MRI enhancing effect is shown. The water-soluble manganese oxide nano particles have good relaxation efficiency, and can obviously shorten the T1 relaxation time of tissues and improve contrast ratio of imaging.

Description

technical field [0001] The invention relates to a preparation method of a magnetic resonance contrast agent, in particular to a preparation method of a water-soluble manganese oxide magnetic resonance contrast agent and the application of the contrast agent. Background technique [0002] Magnetic resonance imaging (Magnetic Resonance Imaging, MRI) is another major development of medical imaging diagnosis technology after CT. Using the principle of nuclear magnetic resonance, according to the different attenuation of the released energy in different structural environments inside the material, and by detecting the emitted electromagnetic waves with an external gradient magnetic field, the position and type of the atomic nucleus that constitutes the object can be known, and based on this, it can be drawn image of the internal structure of the object. Magnetic resonance imaging has outstanding advantages such as high tissue resolution, multiple imaging parameters, and safe use...

Claims

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Application Information

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IPC IPC(8): A61K49/18
Inventor 贾能勤季玉玄
Owner SHANGHAI NORMAL UNIVERSITY
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