Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Vegetable fiber hollow capsule used for medicine and its preparation method

A technology of hollow capsules and plant fibers, which is applied in capsule delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc. It can solve the problem of bleeding, affecting the quality and production qualification rate of medicinal hollow capsules, and the gel strength is too hard And other issues

Active Publication Date: 2012-08-01
INST OF OCEANOLOGY - CHINESE ACAD OF SCI
View PDF3 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] With the deepening of research and the problems encountered in industrial production, it was found that the main coagulant of the patent that has been applied for--seaweed polysaccharide, that is, the K-type carrageenan, has a strong gel strength and bleeding, which directly affects the drug. The quality and production pass rate of empty capsules

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Vegetable fiber hollow capsule used for medicine and its preparation method
  • Vegetable fiber hollow capsule used for medicine and its preparation method
  • Vegetable fiber hollow capsule used for medicine and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] 1) Eucheuma spinosa extract glue containing 50% water:

[0050]Add 20 kg of dried Eucheuma spinosa, rinse with 40 kg of fresh water and drain, add 150 kg of 7% KOH solution, stir and react for 1-1.5 hours, filter out impurities with a 300-mesh sieve and drain. Soak and stir with 0.5M / L hydrochloric acid solution to adjust the pH to 7-8. Add 400 kg of hot water, keep the temperature at 100°C, and pass through a 300-mesh sieve while hot after 60 minutes. After cooling to room temperature, freeze at -15°C for 24 hours, thaw and dehydrate with water at 15°C to obtain a 50% water-containing Eucheuma spinosa extract glue. Alkaline solution

[0051] 2) By weight, when the water is 100 parts (1 kg is 1 part), add 3.0 kg of Eucheuma spinosa extract glue containing 50% water, heat to 85°C while stirring and keep it for 30 minutes, then gradually cool down When the temperature reaches 50°C, add 10 kg of cellulose hydroxypropyl methyl ether (HPMC) and stir evenly for 10 minutes,...

Embodiment 2

[0053] The preparation method of the Eucheuma spinosa extract glue containing 50% water is the same as that in Example 1.

[0054] According to the weight ratio, water is 100 parts, 1.5 kg of Eucheuma spinosa extract glue containing 50% water, 20 kg of 90°C hot water is added while stirring, and the temperature is gradually lowered to 50°C after keeping for 30 minutes. Add 50 kg of distilled water at room temperature to 13 kg of cellulose hydroxypropyl methyl ether (HPMC) while stirring, and stir for 20 minutes until the solution becomes a transparent homogeneous liquid. Add 15 kg of room temperature distilled water to 2 kg of hydroxyethyl methylcellulose (HEMC) while stirring, and keep stirring for 30 minutes until the solution presents a transparent viscous liquid, then combine and stir the above solutions (85 kg) and keep the temperature at 50 ℃. Add 1 kg of modified starch to 15 kg of finishing water, stir well, combine all the solutions, and continue stirring for 10 minu...

Embodiment 3

[0056] The preparation method of the Eucheuma spinosa extract glue containing 50% water is the same as that in Example 1.

[0057] In terms of weight ratio, when the water is 100 parts, add 5.5 kilograms of Eucheuma spinosa extracting glue containing 50% moisture, add 80 kilograms of 90 ℃ hot water while stirring and stir for 30 minutes, then gradually cool down to 60 ℃, add 5 After one kilogram of hydroxyethylmethylcellulose (HEMC) was stirred evenly for 10 minutes, the temperature was naturally lowered to 50° C., and the stirring was continued until the solution appeared transparent. Add 5kg of modified starch into 20kg of hot water at 90°C and stir to dissolve, then combine with the above solution, continue to stir until uniform viscous liquid, keep the temperature at 50°C for 2 hours. Add it into the storage tank of the hollow capsule semi-automatic equipment, keep at 48-50°C for 20 minutes, turn on the machine, let the glue in the storage tank flow into the material tank,...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the marine phytochemistry, alga chemical industry and a pharmaceutical excipient-hollow capsule industry, concretely relates to a vegetable fiber hollow capsule used for medicine and its preparation method. According to weight ratio, the vegetable fiber hollow capsule used for medicine comprises an Eucheuma Spinosum extract with 50% water content, cellulose hydroxypropyl methyl ether (HPMC) or hydroxyethyl methyl cellulose (HEMC), soluble starch or guar gum. According to weight ratio, when the water is considered as 100 parts, the vegetable fiber hollow capsule comprises 1.5-5.5 parts of the extraction glue of Eucheuma Spinosum alkali and water, 0-13 parts of cellulose hydroxypropyl methyl ether (HPMC) or hydroxyethyl methyl cellulose (HEMC), 0-0.1 parts of guar gum and 0-5 parts of modified starch. According to the invention, the extraction glue of Eucheuma Spinosum alkali and water is used for preparing the vegetable fiber hollow capsule used for medicine, and the alga polysaccharide (K-carragheenan ) extracted by E.Cottonii can be substituted.

Description

technical field [0001] The invention relates to marine phytochemistry, seaweed chemical industry and pharmaceutical auxiliary material-empty capsule industry, in particular to a plant fiber medicinal hollow capsule and a preparation method thereof. Background technique [0002] Empty capsules are divided into stomach-soluble empty capsules, enteric-coated empty capsules, soft capsules and hard-shell capsules. Medicinal empty capsule is a special pharmaceutical excipient, it enters the digestive system of the human body together with the pharmaceutical preparation and is absorbed by the human body, so the quality of medicinal empty capsule is directly related to the quality and safety of the finished drug. [0003] The used raw material overwhelming majority of hard-shell hollow capsule (commonly known as animal capsule) preparation at home and abroad is the animal protein colloid gelatin that the skin of pig or ox, bone are made. The hard-shell hollow capsule of animal orig...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/48A61K47/36C08B37/00
Inventor 韩丽君袁毅李宪璀
Owner INST OF OCEANOLOGY - CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com