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Surface-modified sensing element and surface modifying method thereof

A technology for surface modification and sensing elements, which can be used in measuring devices, biological testing, and phase-influenced characteristic measurement. It can solve the problems of uneven hydrophilicity on the surface of metal coatings, increased experimental instability, and lengthy process time. Achieve the effects of enhancing detection effect and accuracy, improving sensitivity and sensitivity, and controlling the density of bonded molecules

Inactive Publication Date: 2012-07-25
FORWARD ELECTRONICS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0004] However, this chemical modification method of soaking in 11-mercaptoundecanoic acid requires a long time soaking reaction, and often the modification result is greatly reduced due to the uneven hydrophilicity of the metal coating surface after modification. , can not achieve the expected effect, so it has the disadvantages of lengthy process time, a large increase in experimental instability and reduced consistency

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  • Surface-modified sensing element and surface modifying method thereof
  • Surface-modified sensing element and surface modifying method thereof
  • Surface-modified sensing element and surface modifying method thereof

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Embodiment 1

[0029] See Figures 1A to 1D , is a schematic flowchart of the method for surface modification of the sensing element of the present invention.

[0030] First, if Figure 1A As shown, a sensing element 20 is provided, wherein a metal film 21 is provided on the surface of the sensing element 20 . In this embodiment, the sensing element 20 is an optical fiber sensing element, such as a side-throwing optical fiber sensing element, which has a sensing area on its surface, and deposits a thin metal film on the surface of the sensing area by sputtering or the like. A gold film is provided as the metal thin film 21 .

[0031] Next, if Figure 1B As shown, a surface modification layer 23 having a plurality of carboxyl groups is formed on the metal thin film 21 of the sensing element 20 by using isopropanol plasma. In this embodiment, the isopropanol plasma is carried out in the following manner: use isopropanol as the raw material gas, pass it into the vacuum discharge tube, and af...

Embodiment 2

[0034] first. As described in the first embodiment, the surface of the sensing element 20 is modified so that the surface modification layer 23 and the polyacrylic acid layer 24 are formed on the surface of the metal thin film 21 of the sensing element 20 .

[0035] Next, if Figure 1E As shown, the use of a coupling activator promotes the activation of the carboxyl group of the polyacrylic acid layer 24, and provides a plurality of biomolecules 25, prompting the amine groups of the biomolecules 25 to bond with the carboxyl groups of the polyacrylic acid layer 24 to form a biological molecular layer. In this example, the coupling activator used is 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide.

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Abstract

The invention relates to a surface modifying method of a sensing element. The method comprises the following steps of: providing a sensing element, wherein the surface of the sensing element is provided with a metal film; utilizing isopropyl alcohol plasmas to form a surface modification layer with multiple carboxyl on the metal film of the sensing element; and forming a polyacrylic layer on the surface modification layer, wherein the polyacrylic acid of the polyacrylic layer is grafted with carboxyl of the surface modification layer. The invention provides the surface-modified sensing element.

Description

technical field [0001] The present invention relates to a surface-modified sensing element and its surface modification method, in particular to a surface-modified sensing element and its surface modification method suitable for increasing the density and uniformity of bonded molecules . Background technique [0002] In recent years, the application of sensing elements in biomolecular detection and film thickness detection in medical diagnosis has become a trend. In the detection of biomolecules, immobilized bio-molecules are usually required to be immobilized on the sensing element. Through the reaction between the biomolecules and the sample to be tested, the signal is changed to measure the type and content of the sample to be tested. . [0003] If the biomolecules need to be bonded to the metal coating on the surface of the optical sensing element, the metal coating needs to be modified first. The traditional biological surface modification technology is to soak the o...

Claims

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Application Information

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IPC IPC(8): G01N33/50G01N21/41G01B21/02
Inventor 张舒婷叶筱玲曹育嘉张荣监曹嘉惠陈克绍
Owner FORWARD ELECTRONICS CO LTD
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