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Method for preparing surface-enhanced Raman spectroscopy substrate of silver self-assembly under assistance of amino acids

A Raman spectroscopic substrate and amino acid technology, which is applied in the photoengraving process of the pattern surface, Raman scattering, opto-mechanical equipment, etc., can solve the problem of poor signal uniformity, complex preparation process, and sensitivity of the nano-silver surface-enhanced Raman spectroscopic substrate. Low problems, to achieve the effect of fast and accurate signal searching, high detection sensitivity, and strong Raman signal

Inactive Publication Date: 2012-07-25
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to solve the problems of poor signal uniformity, low sensitivity, complex preparation process and high cost of the nano-silver surface-enhanced Raman spectrum substrate prepared by the prior art

Method used

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  • Method for preparing surface-enhanced Raman spectroscopy substrate of silver self-assembly under assistance of amino acids
  • Method for preparing surface-enhanced Raman spectroscopy substrate of silver self-assembly under assistance of amino acids
  • Method for preparing surface-enhanced Raman spectroscopy substrate of silver self-assembly under assistance of amino acids

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specific Embodiment approach 1

[0020] Specific Embodiment 1: The preparation method of a surface-enhanced Raman spectroscopy substrate of amino acid-assisted silver self-assembly in this embodiment is carried out according to the following steps: 1. Weigh 100 to 150 parts of distilled water, 10 ~15 parts of 0.1~1mol / L AgNO 3 solution, 1 to 5 parts of 0.01 to 0.1 mol / L amino acid solution and 10 to 15 parts of 0.5 to 1.5 mol / L ascorbic acid solution; 2. Distilled water, AgNO 3 solution and amino acid solution, put them into a round-bottomed flask, stir at a speed of 300-1500 rpm for 5-15 minutes under the condition of a water bath at 0°C to 5°C, add the ascorbic acid solution weighed in step 1, and stir at a speed of 300-1500 rpm for 5-15 minutes. Stir at a speed of 1500 rpm for 10 to 20 minutes to obtain a solid-liquid mixture; 3. Centrifuge the solid-liquid mixture obtained in step 2 at a rotational speed of 2000 to 10,000 rpm to collect the solid phase, and then separate the solid phase Put the substance...

specific Embodiment approach 2

[0026] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the amino acids in the amino acid solution are glycine, alanine, histidine, glutamine, asparagine, aspartic acid, glutamic acid, valine amino acid, leucine, isoleucine, phenylalanine, proline, tryptophan, serine, tyrosine, cysteine, methionine, threonine, lysine, or arginine. Other steps and parameters are the same as those in Embodiment 1.

specific Embodiment approach 3

[0027] Specific embodiment 3: This embodiment differs from specific embodiments 1 to 2 in that: step 1 weighs 120-130 parts of distilled water and 12-13 parts of 0.5-0.7 mol / L AgNO 3 solution, 3-4 parts of 0.05-0.07 mol / L amino acid solution and 12-13 parts of 0.8-1.2 mol / L ascorbic acid solution. Other steps and parameters are the same as those in Embodiments 1 to 2.

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Abstract

The invention discloses a method for preparing a surface-enhanced Raman spectroscopy substrate of a silver self-assembly under the assistance of amino acids, relating to the preparation method of the surface-enhanced Raman spectroscopy substrate and aiming at solving the problems of poor uniformity of signals, low sensitivity, complex preparation process and high cost of a nano-silver surface-enhanced Raman spectroscopy substrate which is prepared by using the prior art. The method for preparing the surface-enhanced Raman substrate comprises the following steps of: injecting little amount of amino acids into a silver nitrate solution under an ice-water bath condition, cooling for a period of time, and then adding ascorbic acid with a certain concentration and reacting to obtain the surface-enhanced Raman spectroscopy substrate of the silver self-assembly with a certain three-dimensional structure. The surface-enhanced Raman spectroscopy substrate can be used for detecting organic molecules and biological molecules of ppm-grade concentration and has the advantages of uniform signal response, high sensitivity, simple and rapid method and low cost. The method disclosed by the invention is applied to the detection field of organic molecules and biological molecules.

Description

technical field [0001] The invention relates to a method for preparing a surface-enhanced Raman spectrum substrate. Background technique [0002] The development of nanoscience and nanotechnology has gradually shifted from the preparation of individual nanoparticles to the preparation of nano-assembled structures, because nano-assemblies with special structures often have comprehensive optical, electronic, catalytic and magnetic properties, which are different from single nanoparticles. There is a big difference in performance. Assemblies with hierarchical structures are the ultimate goal of preparing complex nanostructures. Complex structures assembled from metal nanoparticles often have many nanoscale holes and voids, so they can become better substrate materials for surface-enhanced Raman spectroscopy. [0003] In solution chemistry, surfactants such as polyvinylpyrrolidone (PVP) and cetyltrimethylammonium bromide (CTAB) are commonly used to induce anisotropic growth of ...

Claims

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Application Information

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IPC IPC(8): G01N21/65B81C3/00
Inventor 强亮生康磊磊徐平韩喜江杜耘辰
Owner HARBIN INST OF TECH
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