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Medicinal composition for treating female climacteric syndrome, and preparation method thereof

A composition and syndrome technology, which is applied in the field of preparation of pharmaceutical compositions, can solve problems affecting the absorption and utilization of active ingredients of drugs, and slow release of active ingredients of raw materials, so as to improve the quality of preparations and production efficiency, reduce the dosage of drugs, and enhance The effect of mobility

Inactive Publication Date: 2012-07-25
SHANDONG JINHE DRUG RES DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation methods of Shugeng Capsules in the prior art all adopt the simple physical treatment of pulverizing and mixing the raw materials, and the active ingredients of the raw materials are released slowly, which seriously affects the absorption and utilization of the active ingredients of the drug. It is urgent to introduce modern preparation methods. Provide rapid dissolution, onset of action, and better absorption and utilization of Shugai preparations

Method used

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  • Medicinal composition for treating female climacteric syndrome, and preparation method thereof
  • Medicinal composition for treating female climacteric syndrome, and preparation method thereof
  • Medicinal composition for treating female climacteric syndrome, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-5

[0029] The proportions by weight of the raw materials of the pharmaceutical compositions of Examples 1-5 are as follows:

[0030] Cardamom 148.5g, Polygonatum 25.3g, Asparagus 25.3g, Nutmeg 25.3g, Agarwood 25.3g, Clove 25.3g, Hand ginseng 25.3g.

[0031] The original commercially available Shugeng capsule used for comparison in the experimental example was a product of Qinghai Jinhe Tibetan Medicine Pharmaceutical Co., Ltd.

Embodiment 1

[0032] Example 1. Preparation of a pharmaceutical composition capsule for women's menopausal syndrome

[0033] (1) Take cardamom, nutmeg, agarwood, and clove according to the composition ratio of the raw materials, add 1795.2g of water, and extract the volatile oil for 5h by steam distillation. Collect the volatile oil to obtain 6.39ml. The liquid is filtered to obtain the extraction Liquid A'and medicine residue A;

[0034] Add the collected volatile oil to a 6% by weight of β-cyclodextrin saturated aqueous solution. The volume-to-weight ratio of volatile oil to β-cyclodextrin is 1ml:6g. Under stirring conditions, keep the temperature at 50°C and stir for 4h, 4 Refrigerate at ℃ for 12h, filter with suction, precipitate and dry under vacuum at 50℃ to obtain 43g of volatile oil inclusion compound;

[0035] (2) Take the three medicinal materials of Polygonatum, Asparagus, and Ginseng according to the composition ratio of the raw materials, mix with the medicine residue A after extract...

Embodiment 2

[0037] Example 2. Preparation of a pharmaceutical composition tablet for women's menopausal syndrome

[0038] (1) Take cardamom, nutmeg, agarwood, and clove according to the composition ratio of the raw materials, add 2244g of water, extract the volatile oil for 5h, collect the volatile oil, get 6.24ml, filter the liquid to obtain the extract A′ and medicine residue A;

[0039] Add the collected volatile oil to 4% by weight of β-cyclodextrin saturated aqueous solution. The volume-weight ratio of volatile oil to β-cyclodextrin is 1ml:4g. Under stirring conditions, keep the temperature at 40℃ and stir for 5h, 4 Refrigerate at ℃ for 24h, filter with suction, precipitate and dry under vacuum at 40℃ to obtain 30g of volatile oil inclusion compound;

[0040] (2) Take Polygonatum, Asparagus, and Ginseng according to the composition ratio of the raw materials, mix with the medicine residue A after extracting the volatile oil in step (1), add water and reflux for extraction 2 times, add 2402...

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Abstract

The invention provides a medicinal composition for treating female climacteric syndrome and a preparation method thereof, belonging to the field of medicinal preparation. The preparation method comprises the steps of volatile oil extraction and clathrating, water extraction, preparation making, etc. Compared with preparation prepared by the traditional method, the medicinal composition provided by the invention is prepared by clathrating technology, so that volatile oil stability is improved; ineffective impurities are removed by adopting extraction technology, so that dosage is educed, absorption is accelerated, curative effect is improved, and patient compliance is improved; and modern granulating technology and addition of lubricant are adopted to enhance fluidity, reduce loading error, improve preparation quality and production efficiency.

Description

Technical field [0001] The invention relates to a method for preparing a pharmaceutical composition, in particular to a method for preparing a pharmaceutical composition for treating women's menopausal syndrome, and belongs to the field of pharmaceutical preparations. Background technique [0002] Menopausal syndrome is a transitional period when women's ovarian function gradually declines to complete disappearance. A series of symptoms caused by psychological and physical changes due to the decline of estrogen levels. In Chinese medicine, menopausal syndrome belongs to the category of "pre- and post-menopausal symptoms". The occurrence of this disease is the physiological changes that occur in women before and after menopause, the gradual failure of kidney qi, the deficiency of Chong and Ren, the lack of essence and blood, the gradual disappearance of Tiangui, menstruation and menopause, but some women due to physical or mental factors and other Due to the influence of factors,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61P15/12
Inventor 马振元李丽王海苹任松鹏单玉刚
Owner SHANDONG JINHE DRUG RES DEV
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