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Beta-tricalcium phosphate/polyvinyl alcohol composite hydrogel keratoprosthesis porous support material and preparation method thereof

A composite hydrogel and polyvinyl alcohol technology, applied in medical science, prosthesis, etc., can solve the problems of low mechanical strength, difficult artificial cornea, poor fatigue resistance, etc., achieve good biocompatibility and simple process , the effect of high mechanical properties

Inactive Publication Date: 2012-07-18
深圳华明生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, it has the disadvantages of poor toughness, high brittleness, low mechanical strength and poor fatigue resistance, and it is difficult to process it into a thin artificial cornea with a certain curvature.

Method used

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  • Beta-tricalcium phosphate/polyvinyl alcohol composite hydrogel keratoprosthesis porous support material and preparation method thereof
  • Beta-tricalcium phosphate/polyvinyl alcohol composite hydrogel keratoprosthesis porous support material and preparation method thereof
  • Beta-tricalcium phosphate/polyvinyl alcohol composite hydrogel keratoprosthesis porous support material and preparation method thereof

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preparation example Construction

[0014] The invention provides a β-tricalcium phosphate / polyvinyl alcohol composite hydrogel porous artificial cornea scaffold material, the preparation method of which comprises the following steps: step 1, adding 1 to 3 g of polyvinyl alcohol at 90°C, with a volume ratio of 40% ~70% aqueous solution of dimethyl sulfoxide is heated at constant temperature for 1 hour to prepare polyvinyl alcohol hydrogel; step 2, directly add 0.5~3g of β-tricalcium phosphate and 5~30g of polyvinyl alcohol hydrogel to the polyvinyl alcohol hydrogel Pore ​​agent (the porogen can be glucose, potassium chloride, sodium chloride, and sodium bicarbonate, etc.) and stir in a water bath at 90°C for 1 hour to form a mixture; Step 3: Inject the mixture directly into a sterile mold And under the condition of -40 ~ -5 ℃, it is repeatedly frozen and formed; step 4, the mixture after freezing and forming is soaked in sterile deionized water and sterilized by iodophor to obtain β-tricalcium phosphate / polyvinyl...

Embodiment approach 1

[0017] A β-tricalcium phosphate / polyvinyl alcohol composite hydrogel porous scaffold material for artificial cornea, the preparation method of which comprises the following steps: a. adding 1 g of polyvinyl alcohol to an aqueous solution of 90° C. and a volume ratio of 70% dimethyl sulfoxide Prepare polyvinyl alcohol hydrogel by heating at a medium temperature for 1 hour; b. directly add 0.5 g of β-tricalcium phosphate and 5 g of glucose to the polyvinyl alcohol hydrogel and stir in a water bath at 90 ° C for 1 hour to form a mixture; c .Inject the mixture directly into a sterile mold and freeze and shape it repeatedly at -35°C; d. Soak the frozen and formed mixture (stent material) with sterile deionized water and sterilize it with iodine to obtain β - Tricalcium phosphate / polyvinyl alcohol composite hydrogel porous scaffold material for artificial cornea.

Embodiment approach 2

[0019] A β-tricalcium phosphate / polyvinyl alcohol composite hydrogel porous scaffold material for artificial cornea, the preparation method of which comprises the following steps: a. adding 3 g of polyvinyl alcohol to an aqueous solution of 90°C and 50% dimethyl sulfoxide by volume Prepare polyvinyl alcohol hydrogel by heating at a medium temperature for 1 hour; b. directly add 2g of β-tricalcium phosphate and 15g of potassium chloride to the polyvinyl alcohol hydrogel and stir in a water bath at 90°C for 1 hour to form a mixture; c. Inject the mixture directly into a sterile mold and repeatedly freeze and shape it at -40°C; d. Soak the frozen and formed mixture with sterile deionized water and sterilize it with iodophor to obtain β-phosphate triphosphate Calcium / polyvinyl alcohol composite hydrogel porous scaffold material for artificial cornea.

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Abstract

The invention discloses a beta-tricalcium phosphate / polyvinyl alcohol composite hydrogel keratoprosthesis porous support material and a preparation method thereof. The preparation method provided by the invention comprises the following steps of 1, adding polyvinyl alcohol into a dimethyl sulfoxide aqueous solution, and heating at a constant temperature to obtain polyvinyl alcohol hydrogel, 2, directly adding beta-tricalcium phosphate and a pore forming agent into the polyvinyl alcohol hydrogel, and carrying out isothermal stirring in a water bath to obtain a mixture, 3, directly injecting the mixture into an aseptic mold, and carrying out repeated refrigeration molding, and 4, immersing the mixture subjected to refrigeration molding in aseptic deionized water, and carrying out iodophor disinfection to obtain the beta-tricalcium phosphate / polyvinyl alcohol composite hydrogel keratoprosthesis porous support material. The preparation method provided by the invention can realize material preparation under normal pressure, has simple processes, and can realizes preparation of the beta-tricalcium phosphate / polyvinyl alcohol composite hydrogel keratoprosthesis porous support material which has good biocompatibility, good mechanical properties and high water content.

Description

technical field [0001] The invention belongs to the technical field of implant materials and artificial organs in medical devices, in particular to a β-tricalcium phosphate / polyvinyl alcohol composite hydrogel artificial cornea porous scaffold material and a preparation method thereof. Background technique [0002] The main components of β-tricalcium phosphate ceramics are composed of calcium and phosphorus elements. They do not contain protein components, are non-toxic, have good biocompatibility and cell affinity, and can conduct tissue growth, that is, new tissues can be obtained from β-tricalcium phosphate. The junction between calcium implant and tissue grows along the surface of the implant or the penetrating pores inside. However, it has the disadvantages of poor toughness, high brittleness, low mechanical strength, and poor fatigue resistance, and it is difficult to process it into a thin artificial cornea with a certain curvature. [0003] In addition to the perfor...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/16A61L27/56
Inventor 周莉周金生罗仲宽姚晓明于莉欧阳君君郑家庆
Owner 深圳华明生物科技有限公司
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