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Boron-containing nano-mesoporous and macroporous bioactive glass, and preparation method and application thereof

A bioglass and nano-mesoporous technology, which can be used in glass manufacturing equipment, glass molding, manufacturing tools, etc., can solve the problem of lack of drug loading capacity

Inactive Publication Date: 2012-07-11
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional bioactive ceramic and glass (hydroxyapatite, tricalcium phosphate, bioglass) scaffolds lack efficient drug loading capacity

Method used

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  • Boron-containing nano-mesoporous and macroporous bioactive glass, and preparation method and application thereof
  • Boron-containing nano-mesoporous and macroporous bioactive glass, and preparation method and application thereof
  • Boron-containing nano-mesoporous and macroporous bioactive glass, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1 5B-MBG

[0041] The molar ratio of boron source, calcium source, phosphorus source and silicon source is tributyl borate: Ca(NO 3 ) 2 4H 2 O: triethyl phosphate: tetraethyl orthosilicate, the molar ratio is 5:15:5:75, the amount of template added is 1 / 2 of the aforementioned weight, dissolved in 8 times the weight of ethanol, stirred at room temperature for 1 On the second day, the polyurethane sponge (25 PPI) was washed and completely immersed in the solution for 10 minutes, then transferred to a Petri dish, the excess solution was removed, and the rest was evaporated at room temperature for 24 hours. This process was repeated twice to obtain large The porosity of the pore scaffold. After the sample was completely dried, it was calcined at 700°C for 5 hours.

Embodiment 2

[0042] Example 2 10B-MBG 2 times

[0043] The molar ratio of boron source, calcium source, phosphorus source and silicon source is tributyl borate: Ca(NO 3 ) 2 4H 2 O: triethyl phosphate: ethyl orthosilicate, the molar ratio is 5:15:2.5:70, the amount of template added is 1 / 2 of the weight of boron source, calcium source, phosphorus source, silicon source, dissolved in 10 Double the weight of ethanol, stir at room temperature for 1 day, wash the polyurethane sponge (25 PPI) and completely immerse in this solution for 10 minutes, then transfer it to a petri dish, remove the excess solution, and evaporate the rest at room temperature for 24 hours, This process was repeated twice to obtain the porosity of the macroporous scaffold. After the sample was completely dried, it was calcined at 700°C for 5 hours.

Embodiment 3

[0044] Example 3 10B-MBG 3 times

[0045] MBG with 10% boron

[0046] The molar ratio of boron source, calcium source, phosphorus source and silicon source is tributyl borate: Ca(NO 3 ) 2 4H 2 O: triethyl phosphate: tetraethyl orthosilicate, the molar ratio is 5:15:2.5:70, dissolve in ethanol, stir at room temperature for 1 day, wash the polyurethane sponge (25 PPI) and completely immerse in this solution for 10 minutes, then transferred to a Petri dish, the excess solution was removed, and the rest was evaporated at room temperature for 24 hours. This process was repeated 3 times to obtain the porosity of the macroporous scaffold. After the sample was completely dried, it was calcined at 600°C for 8 hours.

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Abstract

The invention discloses a boron-containing nano-mesoporous and macroporous bioactive glass, a preparation method thereof and the application thereof to medical supports. The boron-containing mesoporous bioactive glass is prepared by substituting BO33- for part of SiO44- by a sol-gel method. According to the method, controllable porosity (78 to 90 percent) is obtained by adjusting immersion times (2 to 5 times) and aperture (300 to 500 microns). The composite glass material has pores suitable for cell growth; tissue growth and nutrition transmission are facilitated due to the porosity characteristic; and the structural integrity of the supports can be maintained in vitro. When the boron content is 0 to 10 percent, the boron-containing ordered mesoporous bioactive glass support has large surface area of 365 to 194 m<2> / g and is suitable for serving as vectors of medicines and growth factors. The biological material can slowly release boron ions, can serve as a tissue repair material applied to bone and periodontium engineering, and can serve as vectors of medicines or genes.

Description

technical field [0001] The invention relates to a boron-containing nanometer mesoporous macroporous bioactive glass material and a preparation method thereof, belonging to the field of biomedical materials. Background technique [0002] Mesoporous bioactive glass (MBG), as a bioactive material, has attracted great attention in recent years. A remarkable feature of mesoporous bioactive glass compared with non-mesoporous bioactive glass (NBG) is that it has a significantly increased specific surface area and nanopore volume, resulting in better apatite mineralization ability and degradation. We recently demonstrated that CaO-P 2 o 5 -SiO 2 Compared with NBG, the system MBG can improve the biological activity, degradation and drug loading ability in vitro and in vivo. As a bioactive material, MBG shows great potential in bone tissue engineering and drug carrier applications. For this reason, it is of great interest to develop an MBG with optimal composition and nanostructu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C03B19/00C03C11/00A61K47/02A61L27/10A61L27/56
Inventor 张玉峰吴成铁罗涛
Owner WUHAN UNIV
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