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Pharmaceutical composition containing lappaconitine and iodine

A technique of clathrin and clathrate hydrobromide, used in combination in the preparation of a medicament for oral cavity and/or throat disease, a medicament for the treatment of oral cavity and/or throat disease, comprising clathrin and iodine In the field of pharmaceutical compositions, it can solve the problems of insignificant bactericidal effect and so on.

Active Publication Date: 2013-08-21
BEIJING HUMANWELL JUNWEI PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of molecular iodine as a bactericidal component in oral compound can effectively solve the problem that the bactericidal effect of existing drugs is not obvious

Method used

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  • Pharmaceutical composition containing lappaconitine and iodine
  • Pharmaceutical composition containing lappaconitine and iodine
  • Pharmaceutical composition containing lappaconitine and iodine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Embodiment 1: the preparation of Gao Ujiasu-iodine buccal tablet

[0056] prescription:

[0057]

[0058] Preparation process: The cediiodine used in the prescription is HP-β-cyclodextrin inclusion complex, the prescription amount is dissolved in 5ml of absolute ethanol, and evenly sprayed in the lactose powder that has passed the 80-mesh sieve, dried at 60°C and then dried at 80°C. Mesh sieve, take the main ingredient and auxiliary materials according to the prescription ratio, pass through an 80 mesh sieve, mix the other raw and auxiliary materials except magnesium stearate according to the method of equal increase, and use 3% hypromellose aqueous solution to make soft materials, After drying in an oven at 60°C, sieve the granules with 18 meshes, add magnesium stearate to the granules, mix them evenly, and press them into tablets. In this embodiment and the following examples, the amount of homogenin hydrobromide refers to the calculation based on its basici...

Embodiment 2

[0059] Embodiment 2: the preparation of Gao Ujiasu-iodine buccal tablet

[0060] prescription:

[0061]

[0062]

[0063] Preparation process: The cediiodine used in the prescription is HP-β-cyclodextrin inclusion complex, the prescription amount is dissolved in 5ml of absolute ethanol, and evenly sprayed in the lactose powder that has passed the 80-mesh sieve, dried at 60°C and then dried at 80°C. Mesh sieve, weigh the main ingredients and auxiliary materials according to the proportion of the prescription, pass through an 80 mesh sieve, mix the other raw materials and auxiliary materials except magnesium stearate according to the method of equal increase, add 3% hypromellose aqueous solution in an appropriate amount to make a soft material , after being dried in a 60°C oven, the granules are sieved through a 18-mesh sieve, and magnesium stearate is added to the granules, mixed evenly and then pressed into tablets to obtain the product.

Embodiment 3

[0064] Embodiment 3: the preparation of Gao Ujiasu-iodine buccal tablet

[0065] prescription:

[0066]

[0067] Preparation process: The cediiodine used in the prescription is gamma-cyclodextrin inclusion compound, cedimenthol is HP-beta-cyclodextrin inclusion compound, the main drug and auxiliary materials are weighed according to the prescription ratio, all pass through 80 mesh sieve, and the hard The other raw and auxiliary materials except magnesium stearate are mixed uniformly according to the method of equal increase, and the soft material is made of 4% hypromellose aqueous solution. Prepare granules, mix evenly and then compress into tablets.

[0068] Described sidimenthol is prepared by the ratio of HP-β-cyclodextrin (referred to as β-CD in the following steps) and Menthol with a weight ratio of 125:20, and its detailed preparation steps are as follows:

[0069] (1) Weigh 125 grams of β-cyclodextrin, put it in a 1000ml three-necked bottle, add 500ml of puri...

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Abstract

The invention discloses a pharmaceutical composition containing lappaconitine and iodine and relates to the use of a composition of therapeutically and / or prophylactically effective amount of lappaconitine or a pharmaceutically-acceptable salt thereof and iodine or a clathrate or complex compound thereof for preparation of medicaments for treating and / or preventing oral and throat inflammatory diseases. The invention further relates to a pharmaceutical composition which contains therapeutically and / or prophylactically effective amount of lappaconitine or a pharmaceutically-acceptable salt thereof, iodine or a clathrate or complex compound thereof and pharmaceutically-acceptable carriers. The pharmaceutical composition has antibacterial, anti-inflammatory and analgesic effects.

Description

technical field [0001] The invention belongs to the field of pharmacy, and relates to a medicine for treating diseases of the oral cavity and / or throat, in particular to a pharmaceutical composition containing ugine and iodine, and the combination of ugine and iodine is used in oral and / or throat preparations. Use in medicine for throat diseases. Background technique [0002] Various oral ulcers, periodontal inflammation, acute and chronic pharyngitis, and tonsillitis are common and frequently-occurring diseases of the oral cavity and throat. These diseases affect people's life, study and physical and mental health to varying degrees. Western medicine believes that the causes of oral and throat diseases are all directly or indirectly related to pathogenic bacteria, and oral ulcers themselves can also be secondary to bacterial infections in the oral cavity, which is the main reason why oral ulcers are difficult to heal, so the treatment of such diseases The key lies in ster...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/18A61K31/79A61K31/439A61P11/04A61P1/02A61P29/00A61P31/04
Inventor 高永良魏丽
Owner BEIJING HUMANWELL JUNWEI PHARM TECH CO LTD
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