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Model of monkey with chronic systemic Parkinson's disease and method for sieving medicament for treating chronic systemic Parkinson's disease

A Parkinson's disease and systemic technology, applied in the field of chronic systemic monkey Parkinson's disease model and its drug screening, can solve the problems of complex modeling methods and high modeling costs, and achieve simple modeling operations and low modeling costs , easy-to-implement effect

Active Publication Date: 2012-07-04
WEST CHINA HOSPITAL SICHUAN UNIV +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these methods have the disadvantages of high modeling cost and complicated modeling methods

Method used

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  • Model of monkey with chronic systemic Parkinson's disease and method for sieving medicament for treating chronic systemic Parkinson's disease
  • Model of monkey with chronic systemic Parkinson's disease and method for sieving medicament for treating chronic systemic Parkinson's disease
  • Model of monkey with chronic systemic Parkinson's disease and method for sieving medicament for treating chronic systemic Parkinson's disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The preparation of embodiment 1 animal model of the present invention

[0029] 1. Materials and methods

[0030] 1. Selected experimental animals:

[0031] Referring to the inclusion criteria of experimental monkeys (see below), 4 healthy adult macaques were purchased from Sichuan Ping An Experimental Animal Breeding Center. Age 5-6 years, weight 4.8-6.3Kg, 2 males and 2 females, represented by M9, M10, M11, M12 respectively. After passing the inspection and quarantine, they are placed in the Large Animal Breeding Center of the National (Chengdu) Traditional Chinese Medicine Safety Assessment Center (GLP) for breeding.

[0032] Inclusion criteria for experimental monkeys:

[0033] ①, age 4-7 years old;

[0034] ②. There are blood routine, biochemical and infectious disease test reports, and the test results are normal, and there is no infectious disease;

[0035] ③. Have not accepted other experimental research in the past;

[0036] ④, weight 4-7Kg;

[0037] ⑤. T...

Embodiment 2

[0090] Example 2 Using classic drugs for the treatment of chronic systemic Parkinson's disease to verify the animal model of chronic systemic Parkinson's disease and preliminarily establish a related drug screening system

[0091] A, get the chronic systemic monkey Parkinson's disease model prepared in Example 1;

[0092] b. Using the currently recognized classic drugs (madopar, xinning) and candidate drugs for the treatment of chronic systemic monkey Parkinson's disease respectively administered to the chronic systemic monkey Parkinson's disease model;

[0093] c. Compared with the classic drugs for the treatment of chronic systemic Parkinson's disease, observe the impact of candidate drugs on the symptoms of chronic systemic Parkinson's disease, wherein the symptoms of chronic systemic Parkinson's disease include: basic motor skills, Fine motor, tremor, bradykinesia, stupor, movement, posture, startle response, hypokinesia, balance, etc.; and quantify it to evaluate the drug...

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Abstract

The invention provides a method for producing a model of monkey with chronic systemic Parkinson's disease. The MPTP with the dose of 0.2mg / kg is fed to the monkey for the first time, then the MPTP with the same dose is fed to the monkey every 2 days for 7 continuous times, and in the following days, the MPTP is fed to the monkey every 3 days for 7 continuous times. The invention further provides a method for sieving a medicament for treating the chronic systemic Parkinson's disease. The modeling method has the advantages that: the modeling operation is simple and is easy to implement, the modeling cost is low, the times of injecting the medicament is few, the model maintaining time is long, the symptom of the model of the monkey is typical, the severity of the symptom of the model of the monkey is moderate, and the monkey is easy to feed.

Description

technical field [0001] The invention relates to a chronic systemic monkey Parkinson's disease model and a drug screening method thereof. Background technique [0002] There are many experimental animal models of Parkinson's disease (PD), including surgical injury of mice and rats or models of damage caused by stereotaxic injection of 6-hydroxydopa. The most valuable model animals should be species that have similar structure, function and complexity to the human nervous system, especially the basal ganglia of the midbrain. The primate PD animal model can reflect the basic characteristics of PD symptoms, and is currently the animal model closest to human PD, which provides a good foundation and platform for the basic research of PD. [0003] Human Parkinson's disease is a chronic neurodegenerative disease that occurs in the central nervous system. It often starts from one side of the limb, and gradually develops to the opposite side of the limb, and the symptoms gradually i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4418A61K49/00A61P25/16
Inventor 王伟李鹏王莉李宏霞刘文科
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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