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Chitin fiber reinforced polylactic acid three-dimensional porous support material and preparation method

A technology of chitin fiber and scaffold material, which is applied in the field of chitin fiber reinforced polylactic acid three-dimensional porous scaffold material and preparation, and repair of bone tissue defects, can solve problems such as pH drop, and achieve good biocompatibility and mechanical properties. Effect

Inactive Publication Date: 2012-06-20
BEIHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as a scaffold material, PLA, on its own, has two major disadvantages: 1. After being prepared as a porous material, its strength is still low compared with natural bone; and the strength decreases too quickly as the degradation progresses [Li XM, Feng QL, Liu XH, Dong W, Cui FZ. Collagen-based implants reinforced by chitin fibers in a goat shank bone defect model. Biomaterials 2006; 27:1917-1923; Li XM, Feng QL, Cui FZ. In vitro degradation of porous nano-hydroxyapatite / collagen / PLLA scaffold reinforced by chitin fibers. Mater Sci Eng.C 2006; 26: 716-720; Li XM, Feng QL, Wang WJ, Cui FZ.Chemical characteristics and cytocompatibility of collagen- based scaffold reinforced by chitin fibers for bone tissue engineering. J Biomed Mater Res B 2006; 77B: 219-226.7]
However, with the local accumulation of lactic acid, the degradation product of PLA, the pH value in the local tissue decreases, and [H+] stimulates the local tissue to cause aseptic inflammation.

Method used

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  • Chitin fiber reinforced polylactic acid three-dimensional porous support material and preparation method
  • Chitin fiber reinforced polylactic acid three-dimensional porous support material and preparation method
  • Chitin fiber reinforced polylactic acid three-dimensional porous support material and preparation method

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Effect test

Embodiment 1

[0037] Example 1: Preparation of chitin fiber reinforced polylactic acid three-dimensional porous scaffold material without protein crosslinking

[0038] (1) Dissolve 6g of polylactic acid PLA in 1,4-dioxane to prepare a solution with a concentration of 100g / L. Then add the chitin fiber CF that has not been cross-linked with PLA PLA in volume content of 30%, and then magnetically stir at room temperature for 2 hours and ultrasonically disperse for 4 hours to obtain uncrosslinked polylactic acid / chitin fiber Mix the liquid.

[0039] (2) Pour the mixed solution prepared in the first step into a polytetrafluoroethylene mold, place it in a refrigerator at -20°C and freeze for 24 hours, then transfer the mold to a freeze dryer for freeze drying for 36 hours.

[0040] (3) Dry the freeze-dried material obtained in the second step in a vacuum drying oven at 50°C for 18 hours.

[0041] (4) The material is sterilized with ethylene oxide steam for 5 hours to obtain a three-dimensional porous sc...

Embodiment 2

[0042] Example 2: Preparation of protein-crosslinked chitin fiber reinforced polylactic acid three-dimensional porous scaffold material

[0043] (1) Dissolve 5 g of chitin fiber CF with a length of 1.1 mm, 15 g of polylactic acid PLA, and 4 g of cross-linking agent N, N'-dicyclohexyl carboimide DCC in dichloromethane at 0°C After 4 hours of magnetic stirring, leave it for 24 hours, then take the CF out of the solution and wash it with dichloromethane three times and deionized water three times, and then dry it in a vacuum drying oven at 40°C to obtain a cross-linked polylactic acid PLA. Linked chitin fiber CF.

[0044] (2) Dissolve 6 g of polylactic acid PLA in 1,4-dioxane to prepare a solution with a concentration of 50 g / L. Then add the chitin fiber CF that has been cross-linked with PLA in the first step with a volume content of 35%. After 2 hours of magnetic stirring and ultrasonic dispersion for 4 hours at room temperature, cross-linked polylactic acid / chitin is prepared. Fi...

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Abstract

The invention discloses a chitin fiber reinforced polylactic acid three-dimensional porous support material and a preparation method, belonging to the technical field of biomedical materials. The support material is composed of polymer material polylactic acid (PLA) with excellent biocompatibility and high-strength fiber CF (chitin fiber) woven from natural polysaccharide chitin. The preparation process mainly comprises a method combining physical mixing and ultrasonic dispersion technologies. In order that the CF has better reinforcing effect, CF and PLA can be cross-linked by adopting a protein cross-linking reagent N,N'-dicyclohexyl carbimide (DCC). The material is a novel support material used for bone repairing, has a three-dimensional porous structure as well as good biocompatibility and mechanical properties, and is expected to serve as a repairing material for bone tissue defects to be widely applied clinically.

Description

Technical field [0001] The invention belongs to the technical field of biomedical materials. More specifically, the present invention relates to a chitin fiber reinforced polylactic acid three-dimensional porous scaffold material for bone tissue defect repair and a preparation method. Background technique [0002] Bone tissue is the largest tissue in the human body and also the most prone to cause defects. Every year, millions of patients with bone tissue damage require surgical treatment. After bone tissue defect, it is usually repaired by autologous bone grafting. The graft substitutes include allogeneic cancellous bone or cortical bone, joints, and demineralized bone matrix. However, it is still not ideal for the reconstruction or repair of the large bone defect of the long bone shaft, the large bone tumor resection, and the joint resection. Autologous bone transplantation is widely used in orthopedics and is one of the most frequently performed surgical operations. Howeve...

Claims

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Application Information

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IPC IPC(8): A61L27/48A61L27/20A61L27/18A61L27/56
Inventor 李晓明黄瑾牛旭峰樊瑜波
Owner BEIHANG UNIV
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