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Sustained-release penicillin anion intercalation hydrotalcite material as well as preparation and application thereof

An anion intercalation, hydrotalcite technology, applied in the field of antibacterial, can solve the problems of poor photothermal stability and easy inactivation, and achieve the effect of improving photothermal stability and inhibiting microbial fouling

Inactive Publication Date: 2012-06-20
INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has the characteristics of poor photothermal stability and easy deactivation after coating, which limits its further application.

Method used

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  • Sustained-release penicillin anion intercalation hydrotalcite material as well as preparation and application thereof
  • Sustained-release penicillin anion intercalation hydrotalcite material as well as preparation and application thereof
  • Sustained-release penicillin anion intercalation hydrotalcite material as well as preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The general formula of the chemical composition of the antibacterial material is [M 2+ 1-x m 3+ x (OH) 2 ] x+ (C 16 h 17 N 2 o 4 S - ) x ·nH 2 O, M 2+ Represents the divalent metal ion Mg 2+ ,M 3+ Represents trivalent metal ion Al 3+ ; 2+ / M 3+ The molar ratio of is 2; x is 0.33.

[0026] Preparation Process:

[0027] The experimental water is the freshly boiled secondary deionized water to remove CO 2 , reacting at N 2 under atmosphere. Mg(NO 3 ) 2 ·6H 2 O and Al(NO 3 ) 3 9H 2 O is made into a 0.75mol / L mixed salt solution (Mg 2+ / Al 3+ =2). NaOH is formulated into a 6mol / L alkaline solution. Add the salt solution and the alkali solution into the four-neck flask at the same time, stir vigorously for 30 minutes, filter, wash and transfer the resulting slurry into a reaction kettle for hydrothermal crystallization at 140°C for 10 hours. The whole process was protected by nitrogen gas. The product was cooled, washed, and centrifuged, and 7....

Embodiment 2

[0037] The general formula of the chemical composition of the anti-corrosion material is [M 2+ 1-x m 3+ x (OH) 2 ] x+ (C 16 h 17 N 2 o 4 S - ) x ·nH 2 O, M 2+ Represents the divalent metal ion Mg 2+ ,M 3+ Represents trivalent metal ion Al 3+ ; 2+ / M 3+ The molar ratio of is 3; x is 0.25.

[0038] The experimental water is the freshly boiled secondary deionized water to remove CO 2 , reacting at N 2 under atmosphere. Mg(NO 3 ) 2 ·6H 2 O and Al(NO 3 ) 3 9H 2 O is made into a 0.40mol / L mixed salt solution (Mg 2+ / Al 3+ =3). NaOH is made into a 4mol / L alkaline solution. Add the salt solution and the alkali solution to the four-necked flask at the same time and stir vigorously for 40 minutes, then filter, wash and transfer the resulting slurry to a reaction kettle for hydrothermal crystallization at 140°C for 12 hours. The whole process was protected by nitrogen gas. The product was cooled, washed with water, and centrifuged, and 8.0 g of freshly prep...

Embodiment 3

[0040] The general formula of the chemical composition of the anti-corrosion material is [M 2+ 1-x m 3+ x (OH) 2 ] x+ (C 16 h 17 N 2 o 4 S - ) x ·nH 2 O, M 2+ Represents the divalent metal ion Ni 2+ ,M 3+ Represents trivalent metal ion Al 3+ ; 2+ / M 3+ The molar ratio of is 4; x is 0.20.

[0041] The experimental water is the freshly boiled secondary deionized water to remove CO 2 , reacting at N 2 under atmosphere. Ni(NO 3 ) 2 ·6H 2 O and Al(NO 3 ) 3 9H 2 O is made into a 1.00mol / L mixed salt solution (Mg 2+ / Al 3+ =4). NaOH is made into 2mol / L alkaline solution. Add the salt solution and the alkali solution into the four-neck flask at the same time, stir vigorously for 60 minutes, filter, wash and transfer the resulting slurry into a reaction kettle for hydrothermal crystallization at 140°C for 16 hours. The whole process was protected by nitrogen gas. The product was cooled, washed, and centrifuged, and 8.5 g of freshly prepared nitrate-interc...

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Abstract

The invention relates to the antibacterial technology, in particular to a sustained-release penicillin anion intercalation hydrotalcite material as well as preparation and application thereof. The hydrotalcite material has the following chemical composition general formula of [M<2+>1-xM<3+>x(OH)2]<x+>(C16H17N2O4S<->)x.nH2O, wherein M<2+> is the divalent metal ion of Mg<2+>, Zn<2+>, Ni<2+>, Fe<2+> or Mn<2+>, M<3+> is the trivalent metal ion of Al<3+>, Cr<3+>, Fe<3+>, V<3+>, Co<3+>, Ga<3+> or Ti<3+>, the molar ratio of M<2+> / M<3+> is 1.6-4.5, and x is more than or equal to 0.2 and is less than or equal to 0.4. The invention provides the sustained-release penicillin anion intercalation hydrotalcite material and a preparation method thereof. The material is characterized in that penicillin anions are introduced be among hydrotalcite layers; penicillin anion antibacterial agent is released by exchanging anions in the environment and the penicillin anions among the layers to achieve the antibacterial purpose and obviously improve the light and heat stability of penicillin molecules, and the sustained-release penicillin anion intercalation hydrotalcite material has the possibility of serving as the filler of the antibacterial coating to achieve the function of inhibiting microorganism staining.

Description

technical field [0001] The invention relates to antibacterial technology, in particular to a sustained-release penicillin anion intercalation hydrotalcite material and its preparation and application. Background technique [0002] The appearance of microbial coating on the surface of materials is called microbial fouling. This covering is called a biofilm. In the marine environment, only the microbial corrosion caused by sulfate-reducing bacteria causes the annual loss of oil industry production, transportation and storage equipment to reach hundreds of millions of dollars. According to incomplete statistics, microbial corrosion loss accounts for about 20% of the total corrosion loss. [0003] Protective coating is the most commonly used method of microbial fouling protection, and its function is mainly realized by biocides. However, traditional fungicides have been gradually banned or restricted due to their high toxicity. Therefore, it is imperative to develop new envi...

Claims

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Application Information

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IPC IPC(8): A01N43/90A01N25/08A01P1/00C09D5/14
Inventor 王毅张盾
Owner INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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