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Preparation method of absorbent composite internal fixator

A technology for fixing devices and composite materials, applied in medical science, surgery, etc., can solve problems such as molecular weight damage, poor mechanical compatibility, and secondary fractures, and achieve good biocompatibility, fast processing, and good mechanical strength. Effect

Inactive Publication Date: 2012-06-13
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Traditional internal fixation devices are usually made of metal materials, but metal materials have some disadvantages: (1) The mechanical compatibility between metal materials and bone tissue is poor, which can easily cause stress shielding and lead to secondary fractures; (2) A second operation is required to remove the non-degradable metal material, which brings pain and economic burden to the patient; (3) The histocompatibility of the metal material is not ideal, and it is easy to cause adverse reactions such as infection and inflammation and tissue necrosis in the body
Although the injection molding method is simple, the polylactic acid raw material is prone to partial thermal degradation, resulting in damage to the molecular weight, resulting in a large decrease in the initial strength of the product

Method used

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Examples

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preparation example Construction

[0025] The preparation method of the absorbable composite internal fixation device of the present invention adopts an integrated process of mixed injection molding, mixes degradable polymers and inorganic particles, and directly performs injection molding to prepare the absorbable composite internal fixation device.

[0026] In a preferred example of the present invention, the hybrid injection molding integration process includes the following steps:

[0027] (a) sending the degradable polymer and inorganic particles into a mixing device for stirring, and mixing uniformly to obtain a composite material;

[0028] (b) extruding the composite material into the barrel, the extrusion time≤3min;

[0029] (c) moving the barrel into an injection molding machine;

[0030] (d) The composite material is subjected to pneumatic injection molding in a mold to obtain the absorbable composite internal fixation device.

[0031] The degradable polymer is one of poly-L-lactic acid, poly-racemi...

Embodiment 1

[0045] Preparation of internal fixation devices

[0046] Poly-L-lactic acid PLLA and hydroxyapatite HAP with an average particle size of 50nm were dried and mixed to obtain a composite material. The mass fraction of PLLA was 80wt%, and the mass fraction of nano-hydroxyapatite HAP was 20wt%. Set the mixing temperature to 170°C, and the mixing and stirring speed to 50r / min.

[0047] Extrude the composite material into the cylinder of the micro-injection machine within 3 minutes, fill it up and compact it, and remove air bubbles. Set the barrel temperature to 170°C, the mold temperature to 100°C, the injection pressure to 750bar, the injection time to 3s, and the dwell time to 50s. After the holding pressure is over, the molds are removed and new molds are rotated in. After cooling down to room temperature, take out the internal fixing device of the product.

[0048] After testing, the tensile strength of the internal fixing device of the product is 62.14MPa, and the modulus o...

Embodiment 2

[0050] Preparation of internal fixation devices

[0051] Polyracemic lactic acid PDLA and hydroxyapatite HAP with an average particle size of 100nm were dried and mixed to obtain a composite material, wherein the mass fraction of HAP was 15wt%, the mass fraction of polyracemic lactic acid PDLA was 85wt%, and the mixing temperature 213°C, mixing speed 70r / min.

[0052] Extrude the composite material into the cylinder of the micro-injection machine within 3 minutes, fill it up and compact it, and remove air bubbles. Set the barrel temperature to 228°C, the mold temperature to 50°C, the injection pressure to 780bar, the injection time to 5s, and the dwell time to 60s. After the pressure holding is completed, the mold is removed, and the new mold is rotated in. After cooling to room temperature, the internal fixing parts of the product are taken out.

[0053] After testing, the tensile strength of the internal fixing device of the product is 61.76MPa, and the modulus of elastici...

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Abstract

The invention relates to a preparation method of a degradable composite internal fixator. According to the method, degradable high molecules and inorganic particles with biological activity undergo a combining injection molding integrated technology to prepare the internally degradable adsorbent composite internal fixator. Various internal fixators prepared by the method provided by the invention have good mechanical strength and good biocompatibility, and are degradable and absorbable in vivo.

Description

technical field [0001] The invention relates to a preparation method of a degradable and absorbable composite internal fixation device, and more particularly relates to a processing and molding method integrating mixing and injection molding. Background technique [0002] Traditional internal fixation devices are usually made of metal materials, but metal materials have some disadvantages: (1) The mechanical compatibility between metal materials and bone tissue is poor, which easily causes stress shielding and secondary fractures; (2) A second operation is required to remove the non-degradable metal material, which brings pain and economic burden to the patient; (3) The histocompatibility of the metal material is not ideal, and it is easy to cause adverse reactions such as infection and inflammation and tissue necrosis in the body. Therefore, a degradable material with good biocompatibility has attracted great attention in the application of various internal fixation devices...

Claims

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Application Information

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IPC IPC(8): B29C45/00B29C45/17B29C45/46A61L31/06A61L31/02A61L31/14
Inventor 刘昌胜李明月王靖
Owner EAST CHINA UNIV OF SCI & TECH
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