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Superparamagnetic electric conductive gamma-iron oxide/polyaniline-lonidamine (gamma-Fe2O3/PAn-Lon) and preparation method thereof

A lonidamine, superparamagnetic technology, applied in electrotherapy, conductive adhesives, electrodes, etc., can solve the problems of affecting the effective therapeutic groups and limitations of drugs, achieve good electrochemical activity, and reduce toxic side effects , Good superparamagnetic effect

Inactive Publication Date: 2012-06-13
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the existing fixed anticancer drugs either affect the effective therapeutic group of the drug or are limited by the release kinetics.

Method used

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  • Superparamagnetic electric conductive gamma-iron oxide/polyaniline-lonidamine (gamma-Fe2O3/PAn-Lon) and preparation method thereof
  • Superparamagnetic electric conductive gamma-iron oxide/polyaniline-lonidamine (gamma-Fe2O3/PAn-Lon) and preparation method thereof
  • Superparamagnetic electric conductive gamma-iron oxide/polyaniline-lonidamine (gamma-Fe2O3/PAn-Lon) and preparation method thereof

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Experimental program
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Embodiment

[0036] 1. Raw materials: aniline (distilled under reduced pressure to colorless and stored in a refrigerator at 4°C for later use), γ-Fe 2 o 3 , ethyl sulfate-1-methyl-3-ethylimidazolium ionic liquid, lonidamine (content 99.5%), and the rest of the raw materials are analytical grade, and the solutions are all prepared with twice distilled water.

[0037] 2. γ-Fe 2 o 3 / PAn preparation: the concentration of 0.1 ~ 5.0mol dm -3 Aniline is mixed with hydrochloric acid solution, and the mixed solution contains 0.1~10.0g·dm -3 Sodium dodecylbenzenesulfonate, add 0.2~10.0g γ-Fe 2 o 3 Add it into the mixed solution and start stirring. During this process, slowly add ammonium persulfate with a molar ratio of 1:1 to aniline, continue stirring for 3 to 60 hours, filter and wash with suction, and then use a solution with a concentration higher than 0.1mol dm -3 Reduction with ammonia water for not less than 2 hours to obtain intrinsic polyaniline, then the solid product was suction ...

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Abstract

The invention relates to superparamagnetic electric conductive gamma-iron oxide / polyaniline-lonidamine (gamma-Fe2O3 / PAn-Lon) and a preparation method thereof. The method comprises the following steps of: mixing aniline and a hydrochloric acid solution to obtain a mixed solution which contains sodium dodecyl benzene sulfonate, adding gamma-Fe2O3, stirring, and adding ammonium persulfate, wherein the molar ratio of the ammonium persulfate to the aniline is 1:1; reducing by using ammonia water to obtain eigen polyaniline, washing by using water, and drying in vacuum to obtain gamma-Fe2O3 / PAn; and adding the gamma-Fe2O3 / PAn into a Lon acidic solution, stirring, performing suction filtering by using a vacuum pump, washing by using water, and drying in vacuum to obtain the gamma-Fe2O3 / PAn-Lon. The defects that the treatment effect cannot be limited in the specific cancerous cell, tissue or organ and normal tissue is damaged are overcome; and by the gamma-Fe2O3 / PAn-Lon, the treatment effect can be limited in the specific cancerous cell, tissue or organ, the normal tissue is not damaged, and the specific pathological cell is identified through electric conductivity of an organism in an organism microenvironment, so that the Lon can better enter a lesion site, and the toxic and side effects of the Lon on healthy tissue are reduced.

Description

technical field [0001] The invention relates to the technical field of chemical synthesis, in particular to superparamagnetic conductive gamma-iron oxide / polyaniline-lonidamine and a preparation method. Background technique [0002] Polyaniline (PAn) has good thermal stability, chemical stability and electrochemical reversibility, and has good biocompatibility, electrical conductivity, doping and dedoping characteristics, and can be modified by many groups. The raw materials of polyaniline are easy to obtain, and the synthesis method is simple, and many new technologies are being developed based on it. [0003] Lonidamine (Lonidamine, Lon), chemical name 1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid, structural formula is as follows: [0004] [0005] It mainly acts on the energy metabolism of cells. By changing the mitochondrial ultrastructure of tumor cells, it can inhibit the oxygen consumption of malignant cells, so as to achieve the purpose of inhibiting and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K50/00A61K47/34A61K47/04A61K31/416A61P35/00
Inventor 阚锦晴张力
Owner YANGZHOU UNIV
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