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Application of Chinese medicinal composition in preparing gel for treating gynecological inflammation

A technology of gynecological inflammation and composition, which is applied in the field of traditional Chinese medicine composition, and can solve problems such as carcinogenesis, female vaginal flora imbalance, and destruction of vaginal self-cleaning system

Inactive Publication Date: 2012-06-06
ZHUZHOU QIANJIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the defects of western medicine are relatively obvious, such as single effect, easy to produce allergies, irritation, drug resistance, etc., not suitable for pregnant women and lactating women, and also has a killing effect on beneficial bacteria in the vagina, which is easy to cause female vaginal bacteria Group disorders, destruction of the vaginal self-cleaning system, etc., some drugs themselves have potential risks of carcinogenicity and teratogenicity (such as metronidazole, metronidazole, etc.)
Existing Chinese medicines also have some deficiencies, some have relatively large prescriptions, and some have cumbersome processes.

Method used

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  • Application of Chinese medicinal composition in preparing gel for treating gynecological inflammation
  • Application of Chinese medicinal composition in preparing gel for treating gynecological inflammation
  • Application of Chinese medicinal composition in preparing gel for treating gynecological inflammation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The preparation of the preferred clinical dosage form " Chun milk gel " of embodiment 1 Chinese medicine composition of the present invention

[0029] 1) Add 6 times the amount of water to 2000 g of Chinese toon skin, add water and decoct twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate to a Chinese toon skin extract with a relative density of 1.05-1.10 (60°C);

[0030] 2) Add 9 times the amount of water to 1500g Sophora flavescens, add water to decoct twice, soak for 1 hour before the first decoction, and decoct for 2 hours each time, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.10- 1.15 (60 ℃) Kushenqing paste, let it cool, add ethanol to make the alcohol content reach 60-70% (measured by hydrometer), let it stand for 20 hours, filter, and recover the ethanol from the filtrate until it has no alcohol smell, and mix it with the toon bark The clear pastes are combi...

experiment example 1

[0036] Experimental Example 1 Toxicological Test Research

[0037] 1. Acute toxicity test

[0038] The traditional Chinese medicine composition of the present invention is administered with 4.0 and 2.0 g crude drug / ml, 0.05 ml / 100 g body weight, and 4 times in 4 hours to rat vagina / cervix. Observed for 24, 48 hours and 7 days. No vaginal / cervical irritation, allergies, etc. were found. There was no obvious poisoning performance in mucous membranes, breathing, circulation, central nervous system, and limb activities, and the body weight all increased.

[0039] 2. Long-term toxicity test

[0040] The traditional Chinese medicine composition of the present invention has 4.0, 2.0, 1.0g crude drug / ml concentration medicinal solution, 0.05ml / 100g body weight, and rat vaginal / cervical administration (4.0, 2.0, 1.0g crude drug / kg) within 2 hours. 9 weeks in a row, observed for 2 weeks after drug withdrawal. Compared with the control group, the general condition, body weight, food ...

experiment example 2

[0044] Experimental example 2 Chinese medicine composition of the present invention treats female Candida albicans vaginitis, trichomonal vaginitis (damp-heat lowering syndrome) clinical observation summary

[0045] In order to study the clinical curative effect of the Chinese medicine composition of the present invention, we observed 20 female patients with candida albicans vaginitis and trichomonas vaginitis (damp-heat lowering syndrome), and the observation results are as follows.

[0046] 1. Clinical data

[0047] 1.1 Source of cases: outpatient clinic. The average age of the cases is 33 years old, the youngest is 21 years old and the oldest is 50 years old.

[0048] 1.2 General situation: See Table 1 below.

[0049] Table 1

[0050]

[0051] 1.3 TCM syndrome diagnosis and disease severity information: see Table 2 and Table 3.

[0052] Table 2 list of TCM syndrome diagnosis cases

[0053]

[0054] Table 3 List of disease severity

[0055]

[0056] 2. Clinical...

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Abstract

The invention relates to application of a Chinese medicinal composition in preparing a gel for treating gynecological inflammation, wherein, the Chinese medicinal composition is prepared by the following bulk medicines by weight: 2000 parts of cortex ailanthi, 1500 parts of sophora flavescens, 1500 parts of frankincense, 50 parts of borneol, and 1500 parts of cortex moutan. The gel prepared by the Chinese medicinal composition in the invention can overcome many defects of chemical medicines, exert the incomparable extensive curative effects (such as heat clearing and dehumidifying, leucorrhea stopping and itching relieving, necrotic tissue removing and granulation promoting) of chemical medicines, and can be widely applied in treating gynecological inflammation (such as damp-heat pouring downward leukorrhagia including bacterial vaginosis, vulvovaginal candidiasis, etc.) caused by bacteria, fungi, protozoa, chlamydiae, mycoplasmas and other pathogens.

Description

technical field [0001] The invention relates to a new application of a traditional Chinese medicine composition, in particular to the application of a traditional Chinese medicine composition gel containing Tsubaki bark in the preparation of a gel for treating gynecological inflammation. Background technique [0002] Due to the special physiological structure characteristics of women, vaginitis is a common and frequently-occurring disease in women of childbearing age, accounting for about 50% of women of childbearing age. Burning sensation and pain at the opening of the urethra seriously affect women's normal work and life. Therefore, active prevention and treatment of gynecological inflammation is an important way to ensure women's health and improve women's quality of life. [0003] At present, there are many kinds of gynecological external medicines used to treat vaginitis in the domestic market, such as gynecological external lotion produced by Chengdu Enwei Pharmaceutic...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61K9/00A61P15/02A61K31/045
Inventor 颜利玲左之文朱大安王振勇
Owner ZHUZHOU QIANJIN PHARMA
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