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Genetic markers for weight management and methods of use thereof

A technology of subject and scheme, applied in the field of genetic markers for weight management and its application, can solve the problems of linkage disequilibrium and linkage disequilibrium of pathogenic polymorphic loci

Inactive Publication Date: 2012-05-02
INTERLEUKIN GENETICS
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Additionally, if a given benign polymorphic locus is in linkage disequilibrium with an apparent pathogenic polymorphic locus, there are other polymorphic genes that are in linkage disequilibrium with the benign polymorphic locus loci, and may also be in linkage disequilibrium with pathogenic polymorphic loci

Method used

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  • Genetic markers for weight management and methods of use thereof
  • Genetic markers for weight management and methods of use thereof
  • Genetic markers for weight management and methods of use thereof

Examples

Experimental program
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Embodiment 1

[0280] Example 1: Calorie (CALERIE calories) (energy restriction intake long-term effects comprehensive assessment of impact) preliminary research.

[0281] Chronic inflammation is associated with metabolic syndrome and central obesity. The aim of this study was to examine whether inflammatory genes such as interleukin-1 (IL-1) genomic polymorphisms (SNPs) were associated with total body weight in response to two diets with different carbohydrate contents under caloric restriction conditions. Correlation of weight loss, fat loss, and resting metabolic rate. The genes of this study were analyzed, and the calorie (CALERIE calorie) (comprehensive assessment of the long-term impact of energy restriction intake) was reviewed in the preliminary study population, using healthy overweight (BMI value 27.8±1.6kg / m2) from 29 genes analyzed 2 ) samples taken from adults. The Calories (CALERIE Calories) pilot study was a one-year randomized rigorously controlled trial in which high o...

example 2

[0301] Example 2. Geisinger study.

[0302] With the support of the calorie study, a second, larger study aimed to investigate the relationship, whether dominant or synergistic, of the SNPs listed in Table 5 with resistance to weight loss from an energy-restricted diet in subjects. In addition, it should be investigated whether metabolic syndrome factors, such as dyslipidemia or abnormal fasting glucose, are associated with these changes.

[0303] table 5.

[0304]

[0305] Research design

[0306] The Geisinger study was conducted in two main phases. In the first phase (~4 months), all subjects were recommended to use a diet containing 1200-1500 (female group) kcal and 1500-1800 kcal- (male group) calories, respectively. Those who lost 3% of their body weight were classified as group A. In the second phase (~4 months), all subjects who lost 5% of their body weight early on were classified as Group B (Early Responders), while those who lost the same body weight at a lat...

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Abstract

This application relates to methods and tests that allow for the establishment of personalized weight-loss programs for a subject based upon the subject's metabolic genotype in key metabolic genes. Kits and methods are disclosed for determining a subject's metabolic genotype, which may be used to select an appropriate therapeutic / dietary regimen or lifestyle recommendation based upon the likelihood of a subject's responsiveness to certain diets and activity levels. Such a personalized weight-loss program will have obvious benefits (e.g., yield better results in terms of weight loss and weight maintenance) over traditional weight-loss programs that do not take into account genetic information.

Description

[0001] This patent application claims the benefit of U.S. Patent Application No. 12 / 466,602, filed May 15, 2009, and U.S. Provisional Patent Application No. 61 / 107,458, filed October 22, 2008, the contents of which are incorporated by reference in their entirety. into this article. technical field [0002] This application relates to methods of determining a subject's metabolic genotype and methods of selecting an appropriate treatment / dietary regimen or lifestyle advice based on the subject's metabolic profile and susceptibility to adverse weight management problems. Background technique [0003] According to a report published by the World Health Organization (WHO) in 1998, obesity has become a global epidemic: about 1.7 billion people are overweight worldwide, of which 3 million are obese. Approximately 127 million adults in the United States are overweight and 69 million are obese. People who are obese are at increased risk of one or more serious medical conditions incl...

Claims

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Application Information

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IPC IPC(8): C12Q1/68
CPCC12Q2600/156C12Q1/6881C12Q2600/118
Inventor N·阿兹V·孔达冈内塔P·普拉哈克尔K·科恩曼
Owner INTERLEUKIN GENETICS
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