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Decolorization method of panax notoginsenoside extract

A technology of Panax notoginseng total saponins and extraction method, which is applied in the directions of blood diseases, pharmaceutical formulations, extracellular fluid diseases, etc., to achieve a good effect of decolorization

Active Publication Date: 2012-04-25
GUANGXI WUZHOU PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the published literature, the highly polar polystyrene copolymer macroporous resin ADS-7 is only used to adsorb mogroside, steviol glycoside and various flavonoids, and there is no report on the decolorization of Panax notoginseng saponins

Method used

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  • Decolorization method of panax notoginsenoside extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1: Extraction and decolorization of Panax notoginseng saponins

[0040] 1. The preparation method of Panax notoginseng total saponins extract:

[0041] Grind Panax notoginseng into coarse powder, extract 5 times with ethanol, use 2 times the amount of 50% ethanol each time, extract for 1 hour each time, combine the extracts, filter, recover the ethanol from the filtrate and concentrate under reduced pressure, and make each 1ml containing crude drug about 0.1g;

[0042] Add 0.5% sodium chloride by volume of the concentrated solution, stir well, let stand for 12 hours, and filter;

[0043] After the filtrate is degreased, pass through a macroporous adsorption resin column at a flow rate of 0.5BV / h, wash with water, and discard the washing solution; , and collect the eluate.

[0044] 2. Decolorization method of Panax notoginseng saponins extract

[0045] The eluate of Panax notoginseng saponins is pressurized to pass through the ADS-7 column of highly polar pol...

Embodiment 2

[0057] Example 2: Extraction and decolorization of Panax notoginseng saponins

[0058] 1. Preparation method of Panax notoginseng total saponins extract:

[0059] Grind Panax notoginseng into coarse powder, extract 3 times with ethanol, use 20 times the amount of 95% ethanol each time, extract 3 hours each time, combine the extracts, filter, and recover the ethanol from the filtrate and concentrate under reduced pressure to make each 1ml containing The crude drug is about 1g. Add 1.5% sodium chloride by volume to the concentrated solution, stir well, let stand for 36 hours, and filter. After the filtrate is degreased, pass through a macroporous adsorption resin column at a flow rate of 2.0 BV / h, wash with water, discard the washing solution, and sequentially use 40%, 50%, 60%, 70%, and 80% ethanol for gradient elution. Collect the eluate.

[0060] 2. Decolorization method of Panax notoginseng saponins extract

[0061] The eluate of Panax notoginseng saponins is pressurized...

Embodiment 3

[0066] Example 3: Extraction and decolorization of Panax notoginseng saponins

[0067] 1. Preparation method of Panax notoginseng total saponins extract:

[0068] Grind Panax notoginseng into coarse powder, extract 4 times with ethanol, use 8 times the amount of 60% ethanol each time, extract 4 hours each time, combine the extracts, filter, recover the ethanol from the filtrate and concentrate under reduced pressure, and make every 1ml containing crude drug About 0.2g. Add 1.0% sodium chloride by volume to the concentrated solution, stir well, let stand for 24 hours, and filter. After the filtrate is degreased, pass through a macroporous adsorption resin column at a flow rate of 10BV / h, wash with water, discard the washing solution, and sequentially use 40%, 50%, 60%, 70%, and 80% ethanol for gradient elution, and collect eluent.

[0069] 2. Decolorization method of Panax notoginseng saponins extract

[0070] The eluate of Panax notoginseng saponins is pressurized to pass ...

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Abstract

The invention relates to a decolorization method of a panax notoginsenoside extract. In the decolorization method, panax notoginsenoside is decolorized mainly by combining strongly polar polystyrene copolymer macroporous resin ADS-7 with neutral aluminium oxide. According to the method, the strongly polar polystyrene copolymer macroporous resin ADS-7 is used for decolorizing, the decolorization effect is good, the amount of residues of the panax notoginsenoside in the resin is reduced, and hydrolysis of the panax notoginsenoside is reduced.

Description

technical field [0001] The invention relates to the field of medical inventions, in particular to a method for decolorizing a Panax notoginseng saponin extract. Background technique [0002] Panax notoginseng, a plant of the genus Ginseng of Araliaceae, is a treasure in the treasure house of traditional Chinese medicine in my country. It is a famous and precious traditional authentic medicinal material. It is similar to ginseng. The traditional medicinal part is the root. Panax notoginseng contains a lot of medicinal chemical components. In terms of compounds, the largest components include saponins, polysaccharides, flavonoids, amino acids, and volatile oils. [0003] Modern pharmacological research shows that the active ingredient of Panax notoginseng, the total saponins of Panax notoginseng, has effects on the human blood system, cardiovascular system, nervous system and metabolic system. During the extraction process of Panax notoginseng, the total saponins of Panax noto...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61P3/00A61P7/00A61P9/00A61P25/00
Inventor 赵学伟黄宇声张栩颜刘冠萍李钊文陈小杰
Owner GUANGXI WUZHOU PHARMA GRP
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