Application of total flavonoids from primula sikkmensis hook

A technology of bellflower primrose and total flavonoids, which is applied in the field of medicine to achieve good anti-inflammatory and analgesic effects

Inactive Publication Date: 2012-04-25
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no report on the use of total flavonoids of Primula bellflower for anti-inflammatory and analgesic

Method used

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  • Application of total flavonoids from primula sikkmensis hook
  • Application of total flavonoids from primula sikkmensis hook
  • Application of total flavonoids from primula sikkmensis hook

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1 The preparation of the total flavonoids of Bellflower Primrose of the present invention

[0021] Take the dried coarse powder of bellflower and primrose, add 20 times the amount of 60% ethanol to soak, heat and reflux for extraction 3 times, each time for 1 hour, filter while hot, combine the filtrate, recover under reduced pressure until there is no alcohol smell, add appropriate amount of distilled water Finally, extract with n-butanol, recover the n-butanol solution under reduced pressure until there is no n-butanol smell, add an appropriate amount of distilled water to dissolve, and after filtration, the pretreated D101 macroporous adsorption resin on the filtrate is first eluted with distilled water until no Ferric chloride reaction and magnesium hydrochloride powder reaction occur, then elute with 30% ethanol, collect the eluent until no ferric chloride reaction and magnesium hydrochloride powder reaction occur, combine the eluent, recover the solvent,...

Embodiment 2

[0023] Example 2 Screening of the preparation method of total flavonoids from Primula bellflower

[0024] 1. Determination method of total flavonoids content

[0025] 1.1 Preparation of reference solution

[0026] Take rutin reference substance 0.01006g, place it in a 50ml volumetric flask, add 60% ethanol to make it up to the mark, and prepare a reference substance solution with a concentration of 0.2012mg / ml for future use.

[0027] 1.2 Preparation of sample solution

[0028] The extract prepared according to each preparation method is transferred to a 100ml volumetric flask, and the volume is fixed to the scale, and 10ml is precisely pipetted from the solution in the 100ml volumetric flask, and the sample solution is obtained by distilling to the volume with 60% ethanol. spare.

[0029] 1.3 Determination of measurement wavelength

[0030] Precisely pipette 7ml of the reference substance solution and 2ml of the test solution, place them in two 25ml volumetric flasks resp...

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PUM

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Abstract

The invention provides application of total flavonoids from primula sikkmensis hook to preparation of anti-inflammatory and analgesic drugs. The invention also provides an anti-inflammatory and analgesic drug composition. The total flavonoids have obvious inhibiting effect on models of such acute inflammations as rat toe swelling caused by carrageenin, mouse ear swelling caused by xylene, mouse celiac capillary permeability increase caused by acetic acid and the like and have inhibiting effect on mouse pains caused by acetic acid and thermal stimulation. The total flavonoids have good anti-inflammatory and analgesic effects, have effects similar to the effects of aspirin and provide a new option for clinical medication.

Description

technical field [0001] The invention relates to a new application of total flavonoids of primrose bellflower, which belongs to the field of medicines. Background technique [0002] Primula sikkmensis Hook, belonging to Primulaceae Primulaceae, has yellow, bell-shaped flowers, clustered on the top of scapes, and is mainly produced in eastern and southern Tibet, southeastern Qinghai, western Sichuan, and northwestern Yunnan. ; Born in forest edge wet grasslands and ditches at an altitude of 3750-4500 meters; distributed in Nepal, Sikkim, Bhutan, and Myanmar. [0003] It is a common Tibetan medicinal material. Tibetan people use the whole herb as an antidiarrheal medicine, and its curative effect is unique and remarkable. It has the effects of clearing heat and detoxifying, purging liver and gallbladder fire, and stopping bleeding. It can also be used for heart stasis and poor blood vessels. The richness makes it widely used in Ganzi Tibetan area. [0004] At present, most o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P29/00A61K133/00
Inventor 彭腾邓赟邱建平李鸿翔贺钢民
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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