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Newcastle disease-H9 subtype avian influenza bivalent dual adjuvant inactivated vaccine and preparation method thereof

An inactivated vaccine, chicken Newcastle disease technology, applied in antiviral agents, pharmaceutical formulations, medical preparations containing active ingredients, etc., to avoid immunosuppression, promote growth and chicken weight gain, and enhance chicken humoral immunity.

Inactive Publication Date: 2012-04-18
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In all reports and patent materials, there is no evidence in ND-AI(H 9 ) Add LMS to the inactivated virus liquid to prepare chicken ND-AI (H 9 ) double double adjuvant inactivated vaccine

Method used

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  • Newcastle disease-H9 subtype avian influenza bivalent dual adjuvant inactivated vaccine and preparation method thereof
  • Newcastle disease-H9 subtype avian influenza bivalent dual adjuvant inactivated vaccine and preparation method thereof
  • Newcastle disease-H9 subtype avian influenza bivalent dual adjuvant inactivated vaccine and preparation method thereof

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Embodiment Construction

[0032] The present invention will be further described in detail below in conjunction with the drawings and specific embodiments:

[0033] The ND-AI(H 9 ) Dual dual adjuvant inactivated vaccine is a kind of vaccine used to prevent Newcastle disease, H 9 A synergistic inactivated vaccine for subtype avian influenza, developed by chicken ND-AI(H 9 ) Composed of two combined oil emulsion inactivated vaccine and immune enhancer, which is characterized by: in conventional chicken ND-AI (H 9 ) Add 0.5-16mg LMS immunopotentiator per ml to the double oil emulsion inactivated vaccine.

[0034] Using the dual dual adjuvant inactivated vaccine provided by the present invention to immunize layers and broilers is better than conventional vaccines ND, AI (H 9 ) The titer of HI antibody is increased by 0.5~2.0Log2, which can stimulate the cellular immune system of the chicken body, and can regulate the suppressed immune function to return to normal. It can protect chickens from Newcastle disease be...

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Abstract

The invention discloses a Newcastle disease-H9 subtype avian influenza bivalent dual-adjuvant inactivated vaccine and a preparation method thereof. The bivalent vaccine consists of a concentrated and inactivated ND and AI (H9) venom, levamisole hydrochloride and an oil adjuvant, wherein every milliliter of inactivated vaccine contains 0.5-16 mg of levamisole hydrochloride immunopotentiator. When the synergic ND-AI (H9) bivalent dual-adjuvant inactivated vaccine prepared with the method is applied to immunized chicken, the humoral immunity and cell immune levels of table poultry and laying hens can be raised effectively, the growth is promoted, and rate of live weight growth is increased. The bivalent dual-adjuvant inactivated vaccine has an immune effect which is remarkably superior to that of the conventional chicken ND-AI bivalent oil emulsion inactivated vaccine, and can be used for effectively protecting chicken flocks from being intruded by the ND virus and AI (H9) virus and preventing the Newcastle disease and H9 subtype avian influenza at the immune period.

Description

Technical field [0001] The invention relates to a double adjuvant vaccine and a preparation method thereof, in particular to a chicken Newcastle disease-H 9 Subtype avian influenza dual-adjuvant inactivated vaccine and its preparation method. Background technique [0002] China is an internationally recognized breeding country, but it is not a breeding power. The low level of prevention and control of animal diseases is one of the important limiting factors restricting my country's entry into the ranks of powerful countries in the breeding industry. The outbreaks and epidemics of avian influenza, highly pathogenic blue ear disease, rabies and other animal or zoonotic diseases have not only caused severe damage to the aquaculture industry, but also aroused public and international attention to my country’s public health and food safety. This has highlighted the urgency and importance of fundamentally improving the level of animal disease prevention and control in my country. [000...

Claims

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Application Information

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IPC IPC(8): A61K39/395A61K39/39A61P31/14A61P31/16A61P37/04A61K39/145A61K39/17
Inventor 刘建王英珍刘海霞
Owner TIANJIN RINGPU BIO TECH
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