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Medicinal composition with effect of treating insomnia, preparation method and application of medicinal composition

A technology of composition and medicine, applied in the field of pharmaceutical composition and its preparation for treating insomnia

Inactive Publication Date: 2012-04-18
常熟雷允上制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the low quality of sleep, people's physical condition gradually deteriorates, which has a great negative impact on work and life. Most people with sleep problems choose chemical drugs, such as diazepam and other drugs to assist sleep, but chemicals have a large Adverse reactions, some have strong tolerance, and the sleep quality is worse after stopping the drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 1. The raw material of the pharmaceutical composition with the effect of treating insomnia: 1.5 parts of Astragalus membranaceus, 1.5 parts of Atractylodes macrocephala, 1.5 parts of Codonopsis pilosula, 1.5 parts of Artemisia annua, 1.5 parts of Digupi, 2 parts of turtle shell, 1.2 parts of raw licorice, and 1.5 parts of Poria cocos .

[0034] 2. The preparation method of the pharmaceutical composition with the effect of treating insomnia:

[0035] (1) Take 1.5 parts of Radix Astragali and 1.5 parts of Atractylodes Rhizoma, add 8 times the amount of ethanol with a concentration of 80% to reflux and extract twice, each time for 2 hours, concentrate under reduced pressure until there is no alcohol smell, and filter with suction to obtain the extracts of Astragalus and Atractylodes Rhizoma. Alcohol extract, diluted with water to contain 40g / L of crude drug, then put on D101 macroporous adsorption resin column, elute resin with 70% ethanol for 6 times of column volume, co...

Embodiment 2

[0044] 1. The raw materials of the pharmaceutical composition with the effect of treating insomnia: 1.55 parts of Astragalus, 1.55 parts of Atractylodes macrocephala, 1.55 parts of Codonopsis pilosula, 1.55 parts of Artemisia annua, 1.55 parts of Digupi, 2.1 parts of turtle shell, 1.25 parts of raw licorice, and 1.55 parts of Poria cocos .

[0045] 2. The preparation method of the pharmaceutical composition with the effect of treating insomnia:

[0046] (1) Take 1.55 parts of Astragalus membranaceus and 1.55 parts of Atractylodes macrocephala, add 6 times the amount of ethanol with a concentration of 85% to reflux and extract for 3 times, each time for 2 hours, concentrate under reduced pressure until there is no alcohol smell, and filter with suction to obtain the extracts of Astragalus membranaceus and Atractylodes macrocephala Alcohol extract, diluted with water to contain 40g / L of crude drug, then put on D101 macroporous adsorption resin column, elute the resin with 70% e...

Embodiment 3

[0055] 1. The raw material of the pharmaceutical composition with the effect of treating insomnia: 2 parts of Astragalus, 2 parts of Atractylodes macrocephala, 2 parts of Codonopsis pilosula, 2 parts of Artemisia annua, 2 parts of Digupi, 3 parts of turtle shell, 2 parts of raw licorice, 2 parts of Poria cocos .

[0056] 2. The preparation method of the pharmaceutical composition with the effect of treating insomnia:

[0057] (1) Take 2 parts of Radix Astragali and 2 parts of Atractylodes Rhizoma, add 8 times the amount of ethanol with a concentration of 80% to reflux and extract for 3 times, each time for 2 hours, concentrate under reduced pressure until there is no alcohol smell, and filter with suction to obtain the extracts of Astragalus and Atractylodes Rhizoma. Alcohol extract, diluted with water to contain 40g / L of crude drug, then put on D101 macroporous adsorption resin column, elute the resin with 8 times the column volume of 70% ethanol, collect each eluate, concen...

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PUM

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Abstract

The invention discloses a medicinal composition with an effect of treating insomnia, a preparation method and application of the medicinal composition. The medicinal composition is prepared from the following Chinese herbal medicines in part by weight: 1 to 5 parts of astragalus, 1 to 5 parts of largehead atractylodes rhizome, 1 to 5 parts of gensing, 1 to 5 parts of sweet wormwood herb, 1 to 5 parts of lycium bark, 1 to 6 parts of turtle shell, 1 to 5 parts of raw liquoric root and 1 to 5 parts of tuckahoe. In the medicinal composition, according to the theory of traditional Chinese medicine, Chinese medicines are prepared by adopting a theory with syndrome differentiation; and clinical experiment results indicate that the medicinal composition can improve sleep quality obviously, has a good effect of treating insomnia, is convenient to take clinically and low in relapse rate and does not have toxic or side effect after being used for a long term. In addition, the preparation method for the medicinal composition is stable, is high in operability and is suitable for large-scale industrial production, the content of extracted active ingredients is high, and impurities are few.

Description

technical field [0001] The invention relates to a medicine, in particular to a medicine composition capable of treating insomnia, a preparation method and application thereof. Background technique [0002] In modern society, people are under a lot of pressure, work and life are in a very tense state, and many people have sleep disorders. According to the "World Sleep Day" survey released by the Psychiatry Branch of the Chinese Medical Association, 45% of people in China have sleep disorders - 500 million people can't sleep well, and this number is still rising. Due to the low quality of sleep, people's physical condition gradually deteriorates, which has a great negative impact on work and life. Most people with sleep problems choose chemical drugs, such as diazepam and other drugs to assist sleep, but there are relatively large risks of chemical drugs. Adverse reactions, some have strong dependence, and the sleep quality is worse after stopping the drug. [0003] As a tra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61P25/20A61K35/56A61K35/586
Inventor 顾治平陈力建王恒斌
Owner 常熟雷允上制药有限公司
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