Traditional Chinese medicine composition for treating Alzheimer type dementia and preparation method thereof

Abstract

The invention provides a traditional Chinese medicine composition for treating Alzheimer type dementia. The active ingredients of the traditional Chinese medicine composition are prepared from the following traditional Chinese medicine raw materials according to a weight ratio: 7.5 g of codonopsis, 5 g of cassia twig, 5 g of radix paeoniae alba, 5 g of licorice, 4.5 g of polygala, 5 g of acorus gramineus and 5 g of dragon's bone. After 107 light and medium-degree AD (Alzheimer's disease) patients undergo treatment for 24 weeks and 48 weeks, the mini-mental state examination (MMSE) treatment effect comparison result is as follows: after treatment for 24 weeks, the effective rate of a western medicine control group is 55.77% and the effective rate of a traditional Chinese medicine group is 52.73%; and after treatment for 48 weeks, the effective rate of the western medicine control group is 44.23% and the effective rate of the traditional Chinese medicine group is 71.71%. The result shows that the traditional Chinese medicine composition for treating Alzheimer type dementia is superior to donepezil when used for treating Alzheimer type dementia. The traditional Chinese medicine composition is clinically applied by direct taking, and is simple for use. The traditional Chinese medicine granules are packaged by aluminum foil bags,, has small volume and is convenient for carrying, and moisture absorption is difficult to occur. The traditional Chinese medicine composition provides a new traditional Chinese medicine treatment direction for treating Alzheimer type dementia, and has greater clinical application value.

Description

technical field [0001] The invention relates to traditional Chinese medicine, in particular to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating Alzheimer's dementia and a preparation method thereof. Background technique [0002] Alzheimer's Disease (AD) was first described by German scientist Alzheimer in 1907. It is a chronic brain degenerative disease with insidious onset. The clinical manifestations are progressive far and near memory impairment, decline in analysis and judgment, emotional changes, abnormal behavior, and even confusion. In the end, most of them die of pneumonia or urinary tract infection. The disease has become the fourth leading cause of death in western countries, second only to heart disease, tumor and stroke. The total prevalence in the United States is about 2.3 million. After the age of 60, the prevalence of AD doubles every five years. By the next 50 years, the population of AD pa...

AI Technical Summary

Problems solved by technology

Another drug, glutamate receptor blocker memantine, is expensive and has many side effects, which brings greater pressure on social security and personal economy

For the treatment of Alzheimer's disease (AD), these drugs are mainly aimed at improving symptoms, but cannot delay the development of the disease

There are also studies on the use of traditional Chinese medicine, but most of them are mixed and decocted, the quality is unstable, and there is no effective control of the curative effect. Therefore, it is expected to develop a traditional Chinese medicine treatment with good curative effect and small side effects

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