Injection prepared from heartleaf houttuynia herb and preparation method thereof

A technology of Houttuynia cordata injection and Houttuynia cordata, applied in botany equipment and methods, medical formulas, medical preparations of non-active ingredients, etc., can solve problems such as inability to guarantee the growth of Houttuynia cordata and supply difficulties of Houttuynia cordata, Achieve the effect of improving the safety of medication, reducing the effect of breaking the cell membrane, and reducing the dosage

Active Publication Date: 2012-04-04
HUNAN ZHENGQING PHARM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Houttuynia cordata has always been a wild plant, and it has been artificially cultivated since the early 1940s. However, due to the low temperature in winter, the growth of the aboveground part of Houttuynia cordata cannot be guaranteed, so the supply of Houttuynia cordata is in trouble
[0003] In the ministerial standard WS3-B-3264-98, the [Preparation Method] item of Houttuynia cordata injection stipulates that the addition amount of polysorbate 80 is 0.5%, but safety studies show that polysorbate 80 has a strong rupture Irritation, hemolysis, and histamine release (sensitization) by the action of cell membranes

Method used

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  • Injection prepared from heartleaf houttuynia herb and preparation method thereof
  • Injection prepared from heartleaf houttuynia herb and preparation method thereof
  • Injection prepared from heartleaf houttuynia herb and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0061] Experimental Example 1: Comparison experiment between greenhouse planting method (see Example 1) and bare land planting method

[0062] 1. The environmental temperature and humidity and the growth effect of Houttuynia cordata were compared between the greenhouse planting method planted in winter and the bare land planting method. The results are shown in Table 1.

[0063] Table 1: Comparison of temperature, humidity and growth effect of greenhouse planting methods

[0064]

[0065]

[0066] The above table shows: ①The temperature of greenhouse planting is relatively constant. ②Houttuynia cordata grown in greenhouses grows faster than Houttuynia cordata planted in bare ground at the same period, the plant growth rate is faster, especially the growth rate of plant height above the ground; at the same time, the growth of fresh weight per plant is also higher.

[0067] 2. Comparison of the growth period of Houttuynia cordata planted in greenhouses and bare land

[...

experiment example 2

[0085] Experimental example 2. Screening experiment of different technical parameters under the condition of Houttuynia cordata greenhouse planting

[0086] 1. Comparison of different planting modes of Houttuynia cordata in greenhouses

[0087] When sowing, the greenhouse experiment adopted three planting modes: ① greenhouse; ② greenhouse + plastic film (see Example 1); See Table 5 for the comparison results of the emergence speed of Houttuynia cordata in different planting modes.

[0088] Table 5: Comparison of emergence speed of Houttuynia cordata with different planting methods in greenhouses

[0089]

[0090] Note: Letters represent a statistically significant 5% difference level.

[0091] From the emergence speed of the greenhouse planting mode in the above table, it can be explained that the third type (greenhouse + plastic film + lamp) is slightly better than the second type (greenhouse + plastic film), but there is no significant difference between the two; ) is ...

experiment example 3

[0124] Experimental Example 3 Screening of the proportion of medicinal parts of Houttuynia cordata

[0125] The raw material of the Houttuynia cordata injection of the present invention is fresh Houttuynia cordata, and the medicinal part is divided into an aerial part and an underground part. The content and weight of different above-ground parts and underground parts were measured in different regions, different seasons and different years, and the feeding ratio of above-ground parts to underground parts was determined. The results are as follows:

[0126] (1) Measure the content of Houttuynia cordata aboveground and underground parts in different regions and years, and the results are shown in Table 10.

[0127] Table 10 Content results of aerial and underground parts of Houttuynia cordata in different regions

[0128]

[0129]

[0130] Note: Component A: 4-methyl-1-isopropyl-3-cyclohexen-1-ol

[0131] Component B: 2-(4-methyl-3-cyclohexenyl)isopropanol

[0132] Com...

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PUM

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Abstract

The invention discloses an injection. On the basis of the conventional production process, tent-planted heartleaf houttuynia herb consisting of an aboveground part and an underground part in a specific ratio is taken as a raw material, so that the quality of products of different batches is stable and uniform; and the dosage of polysorbate 80 is reduced, the cell membrane cracking action, irritation, haemolysis and histamine release (sensitization) caused by the polysorbate 80 are lowered, and the administration safety is improved.

Description

technical field [0001] The invention relates to an injection and a preparation method thereof, in particular to an injection made from Houttuynia cordata and a preparation method thereof. Background technique [0002] Houttuynia cordata is the rooted whole plant of Houttuynia cordata Thunb., a perennial herbaceous plant of the family Tribaceae, also known as Pleurotus chinensis, Purple Houttuynia, Pig Nostril, Jiujielian, etc. Its fresh plants have a pungent fishy smell after being broken , widely distributed in the central, southeast and southwest provinces of my country, especially in Hunan, Hubei, Sichuan, Jiangsu and other provinces. Houttuynia cordata has the effects of clearing heat and detoxifying, eliminating carbuncle and draining pus, diuresis and treating stranguria. It is clinically used for lung abscess and vomiting of pus, phlegm-heat wheezing and coughing, hot dysentery, hot stranguria, carbuncle and sore. Studies have shown that Houttuynia cordata contains vo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/78A61K9/08A61K47/34A01G1/00A61P1/12A61P11/00A61P13/00A61P17/02A61P31/04
Inventor 吴飞驰钟军仇萍熊兴耀向卫国曾维军李苏翠
Owner HUNAN ZHENGQING PHARM GRP CO LTD
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