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Magnetic resonance contrast agent constructed by amphipathic polysaccharide-wrapped super-paramagnetic nanoparticles and preparation method thereof

A magnetic resonance contrast agent and nanoparticle technology, applied in preparations for in vivo tests, pharmaceutical formulations, emulsion delivery, etc., to achieve good imaging contrast, good magnetic properties, and high degree of grafting

Active Publication Date: 2013-07-24
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Currently, there is no such contrast agent available clinically

Method used

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  • Magnetic resonance contrast agent constructed by amphipathic polysaccharide-wrapped super-paramagnetic nanoparticles and preparation method thereof
  • Magnetic resonance contrast agent constructed by amphipathic polysaccharide-wrapped super-paramagnetic nanoparticles and preparation method thereof
  • Magnetic resonance contrast agent constructed by amphipathic polysaccharide-wrapped super-paramagnetic nanoparticles and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0056] The amphiphilic dextran (Dex T10 -g-SA) Preparation

[0057] Weigh 0.284g (1mmol) of stearic acid and 0.171g of N,N'-carbonyldiimidazole (1.05mmol) and dissolve it in 4mL of dry tetrahydrofuran. Under the protection of argon, reflux at a temperature of 80°C for 3h to obtain the solution ① for later use; Weigh 0.202 g of dextran with a molecular weight of 10,000 g / mol and dissolve it in 10 mL of dry dimethyl sulfoxide, heat until completely dissolved, inject solution ① into the reaction solution under the protection of argon, and heat the obtained solution to 130 ° C for 5 h , the solution obtained by the reaction was added to 300 mL ethyl acetate to precipitate and wash three times, and centrifuged to obtain a white solid product. product of 1 H NMR spectrum (DMSO-d 6 / CDCl 3 v:v=1 / 1) Proton hydrogen chemical shift is assigned as figure 1 shown. The results showed that stearic acid was successfully grafted onto dextran, from 1 The H NMR spectrogram can calculate ...

example 2

[0058] The amphiphilic dextran (Dex) of example 2 stearic acid modification T40 -g-SA) Preparation

[0059] Weigh 0.426g (1.5mmol) of stearic acid and 0.255g of N,N'-carbonyldiimidazole (1.58mmol) and dissolve them in 6mL of dry tetrahydrofuran. Under the protection of argon, reflux at a temperature of 80°C for 3h to obtain a solution ② for later use Weigh 0.243g of dextran with a molecular weight of 40000g / mol and dissolve it in 15mL of dry dimethyl sulfoxide, heat until completely dissolved, inject solution ② into the reaction solution under the protection of argon, and heat the obtained solution to 130°C for reaction After 5 h, the solution obtained from the reaction was added to 300 mL of ethyl acetate to precipitate and wash three times, and centrifuged to obtain a white solid product.

example 3

[0060] The amphiphilic dextran (Dex) of example 3 stearic acid modification T70 -g-SA) Preparation

[0061] Weigh 0.426g (1.5mmol) of stearic acid and 0.267g of N,N'-carbonyldiimidazole (1.65mmol) and dissolve them in 6mL of dry tetrahydrofuran. Under the protection of argon, reflux at a temperature of 80°C for 3h to obtain a solution ③ for later use Weigh 0.270 g of dextran with a molecular weight of 70,000 g / mol and dissolve it in 15 mL of dry dimethyl sulfoxide, heat until completely dissolved, inject solution ③ into the reaction solution under the protection of argon, and heat the obtained solution to 130°C for reaction After 5 h, the solution obtained from the reaction was added to 300 mL of ethyl acetate to precipitate and wash three times, and centrifuged to obtain a white solid product.

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Abstract

The invention discloses a magnetic resonance contrast agent constructed by amphipathic polysaccharide-wrapped super-paramagnetic nanoparticles and a preparation method thereof, and the magnetic resonance contrast agent is characterized in that amphipathic polysaccharides take glucosans as main chain grafted hydrophobic chain segment molecules (such as fatty acids), self-assembly is performed in aselective solvent for forming micelles, and hydrophobic super-paramagnetic nanoparticles (such as ferroferric oxide nano-crystals) can be loaded so as to get a water-soluble nano compound. The nano compound has good biological compatibility, and the loaded nanoparticles can keep the original advantages of physical properties. The nano-compound can be used as the magnetic resonance contrast agent,thereby having extensive application prospects in magnetic resonance enhanced imaging, early diagnosis of cancers, image tracking efficacy evaluation and other biomedical fields.

Description

Technical field: [0001] The invention relates to a magnetic resonance contrast agent constructed by amphiphilic polysaccharide-wrapped superparamagnetic nanoparticles and a preparation method thereof. It belongs to the fields of biomedical polymer materials and molecular imaging. Background technique [0002] Superparamagnetic nanoparticles have a wide range of potential applications in biomedicine, electronics and other fields, and have attracted extensive attention from many researchers. High-quality hydrophobic superparamagnetic nanocrystals (Chem Mater, 2004, 16, 3931; J Am Chem Soc, 2004, 126, 273) with controllable size and shape can be obtained by using organic phase synthesis method under high temperature conditions. The controllability is obviously better than that of superparamagnetic nanoparticles synthesized in water phase. However, such high-quality superparamagnetic nanoparticles can only be dispersed in organic solvents and cannot be dispersed in physiologic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/12A61K49/18
Inventor 艾华苏红莹吴昌强
Owner SICHUAN UNIV
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