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Compound pharmaceutical composition of iodine polymer and glucocorticosteroid for treating dermatitis

A technology of glucocorticosteroids and compositions, applied in the field of pharmaceutical preparations, can solve the problems of strong blood toxicity, increased difficulty, insufficient release, etc., achieve good therapeutic efficacy, good synergy, and reduce toxic and side effects

Inactive Publication Date: 2012-03-21
JIANGSU DEDA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As we all know, because of cyclodextrin inclusion technology 1. Limited inclusion materials, acetone, ethanol and other organic substances are often found in the preparation process, which can easily cause strong blood toxicity and damaging kidney toxicity, which is not conducive to human health.
2. There are restrictions on the molecular size, polarity, and structure of inclusion drugs. Since the molecular size, polarity, and structure of glucocorticoids are different, cyclodextrin inclusion technology is not universal
4. The encapsulation rate of cyclodextrin inclusion is not high, resulting in increased difficulty in the process
5. There is an unknown effect on the release of the drug after the cyclodextrin inclusion, such as the release rate, may not reach the effective concentration of the drug that needs to be maintained due to insufficient release

Method used

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  • Compound pharmaceutical composition of iodine polymer and glucocorticosteroid for treating dermatitis
  • Compound pharmaceutical composition of iodine polymer and glucocorticosteroid for treating dermatitis
  • Compound pharmaceutical composition of iodine polymer and glucocorticosteroid for treating dermatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0120] Preparation of PVP-I (0.1%) Fluticasone Propionate (0.01%) Compound Suspension

[0121] components

Dosage (grams)

fluticasone propionate

0.24

Povidone iodine

2.4

potassium iodate

0.072

Avicel 591 (microcrystalline cellulose and sodium carboxymethyl cellulose)

15

Sodium chloride

4

Taylor Saber

0.39

EDTA-Na

0.25

[0122] Preparation:

[0123] Add 0.24g of micronized fluticasone propionate and prescription amount of teroxabor to 40g of sterile water in sequence and homogenize for more than 12 hours, then add microcrystalline cellulose, sodium carboxymethylcellulose, sodium chloride, EDTA- Na and purified water form a suspension. Dissolve 2.4 g of povidone-iodine dry powder, potassium iodate, in this suspension. Add about 2000mL of water to the lavage bottle, add sodium hydroxide to adjust the pH to 4.0, and quantify to 2400 grams, so that the suspension solu...

Embodiment 2

[0125] Preparation of PVP-I (0.5%) fluticasone propionate (0.025%) cream

[0126] components

Dosage (grams)

fluticasone propionate

0.06

Povidone iodine

1.2

cetyl alcohol

2

potassium iodate

0.0072

Sodium dodecyl sulfate

2.1

White Vaseline

33.5

liquid paraffin

13.5

Glycerin

11.2

stearic acid

9

Glyceryl monostearate

8

Water for Injection

159.4

Tween 80

0.09

EDTA-Na

0.025

[0127] Preparation:

[0128] 1. Add the prescribed amount of povidone-iodine and potassium iodate into 20 grams of water for injection, dissolve in advance to obtain solution A, and keep warm in a water bath at 55°C.

[0129] 2. Add 20 grams of water to the micronized fluticasone propionate and add the prescribed amount of Tween 80 and EDTA-Na, homogenize in a homogenizer for more than 12 hours to obtain solution B, and k...

Embodiment 3

[0134] Preparation of PVP-I (1%) fluticasone propionate (0.5%) gel

[0135] components

Dosage (grams)

fluticasone propionate

1.2

Povidone iodine

2.4

potassium iodate

0.0072

Carbomer 941

1

Sodium chloride

0.4

Poloxamer

0.8

EDTA-Na

0.0244

[0136] Preparation:

[0137] Put the prescribed amount of Carbomer 941 into 100 grams of water, and swell for 24 hours to obtain a uniform swelling solution A.

[0138] Add the prescribed amount of micronized fluticasone propionate to the prescribed amount of poloxamer and homogenize for more than 12 hours to obtain suspension B.

[0139] Prepare 2.4 grams of povidone-iodine, the above-mentioned swelling solution A, carbomer 941, the above-mentioned suspension B, sodium chloride, potassium iodate, EDTA-Na and water for injection, and add sodium hydroxide to adjust the pH value to 4.0, add water quantitatively to a total weight of...

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Abstract

The invention relates to the field of medicinal preparation and relates to a compound pharmaceutical composition of iodine polymer and glucocorticosteroid for treating dermatitis. The pharmaceutical composition of the present invention comprises 0.01-5% of polyvinylpyrrolidone iodine, 0.01-10% of glucocorticosteroid, 0.001-0.5% of potassium iodate and the balance of pharmaceutically accepted carrier, wherein the glucocorticosteroid is fluticasone propionate or halometasone. Drug effect test has proved that the compound medicament can treat dermatitis by synergism; furtherly, addition of a certain proportion of potassium iodate overcomes unfavorable influences of drug effect decrease or auxiliary effect caused by medicament instability.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a compound pharmaceutical composition of iodine polymer and glucocorticoid for treating dermatitis. Background technique [0002] Skin inflammations such as eczema, allergic dermatitis, atopic dermatitis, urticaria, etc. are caused by allergic reactions caused by certain allergens, resulting in skin inflammation and skin inflammation. There are many kinds of allergens in allergic reactions, among which infections such as viruses, fungi, and bacteria are one of the important causes of skin inflammation, and bacterial infection is an important sensitizing factor in various skin inflammations such as allergic dermatitis. Glucocorticoids are widely used in the treatment of skin inflammation, but due to the immunosuppressive effect of glucocorticoids, when glucocorticoids are used to treat inflammation caused by bacterial infection on the skin surface, not only can not achie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/79A61K31/573A61K31/56A61P29/00A61P17/00
CPCA61K9/10A61K31/56A61K31/573A61K31/79A61P17/00A61P29/00A61K2300/00
Inventor 梁波郭靖陆勇
Owner JIANGSU DEDA PHARMA
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