Compound amino acid preparation for hemodialysis and hemodialysis preparation containing same

Abstract

The invention relates to a compound amino acid preparation for hemodialysis and a hemodialysis preparation containing the same. The invention provides a preparation for modulating disorder of plasma aminogram of hemodialysis patients by using a plurality of essential amino acids and semi-essential amino acids, specifically relates to a solid powder form or liquid bicarbonate hemodialysis preparation used for treating nephrosis and containing compound amino acids, and especially to a hemodialysis preparation containing L-leucine, L-isoleucine, L-valine, L-threonine, L-phenylalanine, L-methionine, L-tryptophan, L-lysine, L-histidine, L-arginine and a pH conditioning agent (e.g., acetic acid, citric acid, malic acid, lactic acid and hydrochloric acid) and a preparation method thereof. The hemodialysis preparation further contains sodium chloride, potassium chloride, calcium chloride, magnesium chloride and sodium bicarbonate, and can also include glucose. Compared to conventional bicarbonate hemodialysis preparations, the preparation provided in the invention has the advantages of partly modulating disorder of plasma aminogram of hemodialysis patients and reducing side effects in hemodialysis treatment.

Description

Technical field [0001] The invention relates to a compound amino acid for hemodialysis, in particular to a hemodialysis preparation for kidney patients using various amino acids as nutritional supplements in hemodialysis treatment and a preparation method thereof. Background technique [0002] As we all know, the impairment of renal function will increase the chance of malnutrition in patients with kidney disease. Many experiments have proved that in acute renal failure and chronic renal failure, protein and amino acid metabolism is abnormal, which is manifested by abnormal plasma amino acid levels and intracellular amino acid levels. The reasons are related to many factors: 1. Loss of appetite, vomiting, diarrhea, long-term low-protein diet, so that essential amino acids are reduced. 2. The kidney's ability to excrete non-essential amino acids decreases, resulting in an increase in non-essential amino acids. 3. Patients with renal failure and hemodialysis often have VitB 6 The ...

AI Technical Summary

Problems solved by technology

2. The ability of the kidneys to excrete non-essential amino acids decreases, resulting in an increase in non-essential amino acids

3. Patients with renal failure and hemodialysis are often combined with VitB 6 The lack of branched-chain amino acids such as leucine, isoleucine, and valine reduces the concentration of branched-chain amino acids, and because of the small molecular weight of amino acids, they are easily removed by hemodialysis. Many clinical studies have proved that every time hemodialysis treatment, patients Lose 5-8g of amino acids, of which essential amino acids are reduced from 22.4±3.3mg% before dialysis to 16.85±4.09mg% after dialysis, thus causing more obvious amino acid metabolism disorders in uremia patients