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Method for synthesizing selective adsorption film material of ofloxacin

A technology of ofloxacin and synthetic methods, which is applied in chemical instruments and methods, alkali metal compounds, alkali metal oxides/hydroxides, etc., can solve the problems of long polymer synthesis time, poor polymer recognition function, and particle size Uneven size and other problems, to achieve the effect of easy control of reaction conditions, high selectivity and stability, and fast polymerization time

Inactive Publication Date: 2012-02-15
CHANGSHU INSTITUTE OF TECHNOLOGY
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Problems solved by technology

However, the traditional molecular imprinting method has disadvantages such as long polymer synthesis time, complicated post-processing, non-uniform particle size, and poor polymer recognition function.

Method used

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Embodiment Construction

[0019] The implementation steps of the present invention are described in detail below with specific examples:

[0020] 1) Add 1 ml of dimethyl sulfoxide solution, 141 mg of acrylamide, 8 mg of N,N'-methylenebisacrylamide, 6 μl of methyl methacrylate and 18 mg of oxygen into a 20 ml stoppered test tube. Flufloxacin, ultrasonically mix for 10 to 20 minutes, and stand at room temperature for 1 to 2 hours.

[0021] 2) Under the protection of nitrogen, add 0.004 mg of ammonium persulfate solution and 6 microliters of tetramethylethylenediamine to the above solution, mix with ultrasonic for 5 minutes, continue to fill the solution with nitrogen for 5 to 10 minutes, and take the mixed solution 200 microliters were evenly dripped onto the glass slide, and allowed to stand at room temperature for 10 minutes to allow it to polymerize to form a film.

[0022] 3) Rinse the above-mentioned polymeric film three times with methanol, then soak it in a mixed solution of methanol and acetic a...

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Abstract

The invention relates to a method for synthesizing a selective adsorption film material of ofloxacin, which is mainly and technically characterized in that the ofloxacin is used as a template molecule, acrylamide and methyl methacrylate are used as functional monomers, N,N'-methylene bisacrylamide is used as a crosslinking agent, and an ammonium persulphate solution and tetramethyl ethylene diamine are used as initiating agents so as to synthesize an adsorption film material with high selectivity to the ofloxacin. According to the method for synthesizing the selective adsorption film material of the ofloxacin, the process is scientific, the cost is low, the operation is simple and quick, and the reaction condition is easy to control. The polymer film material used as an adsorbent can be selectively used for enriching a trace ofloxacin medicine in animal foods.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a method for synthesizing a polymer membrane material with adsorption function of ofloxacin. Background technique [0002] Fluoroquinolones are a class of synthetic spectrum antibacterial drugs, and their development began in the 1980s. This type of drug has the characteristics of broad antibacterial spectrum, strong antibacterial effect, wide distribution in the body, high tissue drug concentration, low protein binding rate, convenient use, small adverse reactions and low price, and has become the fastest-growing chemically synthesized antibacterial drug. Clinically, it is widely used in the treatment of various infectious diseases in animals and humans. Ofloxacin (OFL) is a representative fluoroquinolone drug, which is widely used in the treatment and prevention of bacterial diseases in livestock and poultry due to its broad antibacterial spectrum and str...

Claims

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Application Information

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IPC IPC(8): B01J20/26B01J20/28B01J20/30
Inventor 权英张根华詹月华陈梦玲
Owner CHANGSHU INSTITUTE OF TECHNOLOGY
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