Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Application of Cortex Ilicis Rotundae saponin compound in preparing anti-inflammatory and analgetic medicament

An anti-inflammatory and analgesic compound technology, applied in anti-inflammatory agents, drug combinations, medical preparations containing active ingredients, etc., can solve problems such as unknown active ingredients, adverse reactions, and difficult quality control

Active Publication Date: 2012-02-08
安士制药(中山)有限公司
View PDF3 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because these drugs have glucocorticoids, also known as steroid-like anti-inflammatory and anti-rheumatic effects, but have different chemical structures from steroidal anti-inflammatory and analgesic drugs, they are also called non-steroidal anti-inflammatory analgesics. Pain medicine is widely used clinically to treat acute and chronic inflammation and pain, but long-term use can easily cause adverse reactions in gastrointestinal tract, kidney, liver and blood system and other tissues and systems. 15): 111-112
The anti-inflammatory and analgesic drugs of traditional Chinese medicine are mostly compound prescriptions, but due to unknown active ingredients, the quality is difficult to control

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of Cortex Ilicis Rotundae saponin compound in preparing anti-inflammatory and analgetic medicament
  • Application of Cortex Ilicis Rotundae saponin compound in preparing anti-inflammatory and analgetic medicament
  • Application of Cortex Ilicis Rotundae saponin compound in preparing anti-inflammatory and analgetic medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Example 1 Preparation of Pelicin and Bispinic Acid

[0075] Extract 20Kg of Ilex rotunda Thunb. with 95% ethanol, concentrate the extract to 5.6Kg, add 16Kg of water, filter, take the insoluble matter or precipitate as the crude extract, and disperse the extract with silica gel In the continuous extraction separator, heat reflux with dichloromethane to extract first, recover the solvent, and save the crude biscinic acid, then use dichloromethane to recrystallize the rescued biscinic acid, and use high-performance liquid chromatography to determine the content of 98.8%; The residue in the vessel was extracted by heating under reflux with ethyl acetate, and the solvent was recovered to obtain the crude product of glucoside. The product was recrystallized with 60% ethanol to obtain glucoside, and the content was determined by high performance liquid chromatography to reach 99.2%. .

Embodiment 2

[0076] Example 2 Preparation of Pelicoside Capsules

[0077] Take 210g of glucoside, grind it into fine powder, add about 150g of 20% starch paste, mix, granulate with a 14-mesh sieve, dry at 100°C, granulate, add 20g of starch, 2g of magnesium stearate, mix well, pack Put into capsules, make 1000 grains, and get final product. Each capsule weighs 0.25g and contains 200mg of glucoside.

Embodiment 3

[0078] Example 3 The preparation of basic acid tablet

[0079] Extract 160g of Bingic acid, grind it into fine powder, add about 150g of 20% starch paste, mix, granulate with a 14-mesh sieve, dry at 100°C, granulate, add 20g of starch, 2g of magnesium stearate, mix well, and press Into 1000 pieces, that is. Each tablet weighs 0.2g and contains 150mg of uric acid.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides an application of a Cortex Ilicis Rotundae saponin compound in preparing an anti-inflammatory and analgetic medicament, relates to the field of medicine and particularly relates to an application of a Cortex Ilicis Rotundae saponin compound. The Cortex Ilicis Rotundae saponin compound can be used for preparing the anti-inflammatory and analgetic medicament, wherein the Cortex Ilicis Rotundae saponin compound is shown in a formula disclosed in the specification, wherein R is H or / and R is beta-D-glucose. In terms of the extraction of the active components of the medicament, raw materials can be obtained easily, the process is simple, the operation is convenient, and batch production can be realized; the product quality can be controlled easily; and the anti-inflammatory and analgetic medicament is low in toxicity, less in side effect and effective.

Description

Technical field [0001] The invention involves the field of pharmaceuticals, which specifically involves the purpose of saving the hyplastic compound to prepare anti -inflammatory analgesic drugs. Background technique [0002] The rescue of traditional Chinese medicine must be the dry bark of the winter youth plant Ilex Rotunda Thunb., Acute and chronic hepatitis, acute gastroenteritis, gastric and duodenal ulcers, rheumatoid joint pain.There are not many chemical composition research reports for rescue. In the literature "Research on the Establishment of Chemical Components" (Chinese Herbal Medicine, 1991, 22 (6): 246-248), it was reported that the rescue should be in the iron winter youth.It should be acidic, qi -qi greenin, is long stems and winter greenin, iron winter green acid isopopype ketones, clovein, mustard, mustard, glucoside, lilacin, and 3 one acetyl oleic acid, and hard fatty acid. [0003] The content of the Chinese citizen is as high as 8.8%. If the content of the...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61P29/00
Inventor 徐清波刘国樵徐孝先王武平李家炜
Owner 安士制药(中山)有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com