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Chinese medicinal herb preparation for lead removing treatment and preparation method thereof

A technology of traditional Chinese medicine preparations and medicinal materials, applied in the field of traditional Chinese medicine preparations and its preparation, can solve the problems of toxic side effects, body damage, transient increase of serum ALT activity, damage to veins and kidneys, etc.

Inactive Publication Date: 2012-02-01
浙江省中药研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these commonly used lead-dispelling therapeutic drugs have multiple side effects, and the main toxic and side effects of edetate disodium calcium are kidney damage and trace element imbalance; and the main reaction of dimercaptosuccinic acid (DMSA) is digestive tract reaction, which can There is a transient increase in serum ALT activity, and allergic reactions such as chills, fever, rash, etc.
Excessive CaNa2EDTA intravenous infusion can damage veins and kidneys
For children, the toxic side effects of these drugs can cause more damage to the body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0016] The steps of the preparation method of the traditional Chinese medicine preparation for lead-expelling treatment are as follows:

[0017] 1) Take 180-220g mung beans, grind them into fine powder, add 1000ml of water, adjust the pH to 8.5-9.5 with saturated NaOH solution, soak 2-3 times, 20-30 minutes each time, and keep stirring; filter through a 200-mesh sieve to obtain mung bean dregs, add 10% HCl solution to the filtrate to adjust the pH value to 5-5.5, then filter through a 200-mesh sieve, and freeze-dry the filter residue to obtain mung bean protein powder for later use;

[0018] 2) Take the mung bean dregs from step 1), add 1000ml of water, decoct 2-3 times, filter, concentrate, add ethanol, adjust the ethanol content to 60%, recover ethanol under reduced pressure, and obtain a concentrated solution, take the concentrated solution and put polyamide on it Chromatographic column, the loading volume ratio of mung bean medicinal material to polyamide is 0.9-1.1g: 0.9-...

Embodiment 1

[0023] 1) Take 180g mung beans, beat them into fine powder, add 1000ml of water, adjust the pH to 8.5 with saturated NaOH solution, soak twice, 20 minutes each time, and keep stirring; filter through a 200-mesh sieve to obtain mung bean dregs, and add 10% HCl to the filtrate Adjust the pH of the solution to 5, then filter through a 200-mesh sieve, and freeze-dry the filter residue to obtain mung bean protein powder, which is set aside;

[0024] 2) Take the mung bean dregs from step 1), add 1000ml of water, decoct twice, filter, concentrate, add ethanol, adjust the ethanol content to 60%, recover the ethanol under reduced pressure to obtain a concentrated solution, and take the concentrated solution for polyamide chromatography Column, the loading volume is mung bean medicinal material and polyamide volume ratio is 0.9g:0.9ml, the elution rate is 0.4BV / h; after elution of impurities with 5 column volumes of deionized water, mung bean flavonoids are eluted with 75% ethanol , the...

Embodiment 2

[0029] 1) Take 220g mung beans, beat them into fine powder, add 1000ml of water, adjust the pH to 9.5 with saturated NaOH solution, soak 3 times, 30 minutes each time, and keep stirring; filter through a 200-mesh sieve to obtain mung bean dregs, and add 10% HCl to the filtrate Adjust the pH value of the solution to 5.5, then filter through a 200-mesh sieve, and freeze-dry the filter residue to obtain mung bean protein powder, which is set aside;

[0030] 2) Take the mung bean dregs from step 1), add 1000ml of water, decoct 3 times, filter, concentrate, add ethanol, adjust the ethanol content to 60%, recover ethanol under reduced pressure, obtain a concentrated solution, and take the concentrated solution for polyamide chromatography Column, the loading volume is mung bean medicinal material and polyamide volume ratio is 1.1g: 1.1ml, the elution rate is 0.6BV / h; after the impurities are eluted with 7 column volumes of deionized water, mung bean flavonoids are eluted with 85% eth...

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Abstract

The invention discloses a Chinese medicinal herb preparation for a lead removing treatment and a preparation method thereof. The Chinese medicinal herb preparation contains the following medicinal materials as raw materials: 180-220 g of mung bean, 144-176 g of semen euryales and 36-44 g of dark plum. The preparation method comprises the following steps of: 1) taking the mung bean and grinding the mung bean to fine powder; soaking the powder with water and stirring the solution; filtering the solution to obtain mung bean dregs; filtering filtrate; and freezing and drying filter residue, to obtain mung bean protein powder; 2) adding water into the mung bean dregs; decocting, filtering and concentrating the solution to obtain concentrated liquid; taking an upper polyamide chromatographic column of the concentrated liquid; eluting mung bean flavone, and filtering to obtain a mung bean flavone solution; 3) taking the semen euryales and the dark plum; adding water into the semen euryales and the dark plum, respectively; decocting and filtering the solutions; concentrating the filtrates to obtain semen euryales extract and dark plum extract, respectively; 4) mixing the mung bean flavone solution with the semen euryales extract and the dark plum extract; adding dextrin, and spraying and drying the mixture, to prepare extract powder for future use; and 5) mixing the mung bean protein powder with the sprayed and dried extract powder, to further prepare granules. The preparation provided by the invention has the effects of removing lead or prompting the lead to be removed, and the actions of treating and releasing lead poisoning symptom.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a traditional Chinese medicine preparation for lead-expelling treatment and a preparation method thereof. Background technique [0002] For the treatment of lead poisoning, complexing agents calcium sodium edetate (CaNa2EDTA) and sodium dimercaptosuccinate (DMSA) are the most commonly used drugs today. However, these commonly used lead-dispelling therapeutic drugs have multiple side effects, and the main toxic and side effects of edetate disodium calcium are kidney damage and trace element imbalance; and the main reaction of dimercaptosuccinic acid (DMSA) is digestive tract reaction, which can There is a transient increase in serum ALT activity, and allergic reactions such as chills, fever, and rash. CaNa2EDTA intravenous infusion concentration is too high can also damage the veins and kidneys. For children, the toxic side effects of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P39/02A61K36/736
Inventor 徐强杨苏蓓王溶溶陈丹菲杨毅
Owner 浙江省中药研究所有限公司
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