Application of ginkgolic acid in preparation of external preparation for treating dermatopathy
A technology of ginkgo phenolic acid and external preparation is applied in the fields of biomedicine and therapeutic cosmetics, and can solve the problems such as unseen use of ginkgo phenolic acid, deterioration of skin lesions, side effects, etc., and achieves the promotion of wound healing, wide effect, safe use and no side effects. Effect
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Embodiment 1
[0077] The extraction process of ginkgolic acid from the ginkgo fruit outer testa is as follows: the ginkgo fruit outer testa is peeled off, dried in the sun, and pulverized with a pulverizer. Accurately weigh a certain amount of crushed ginkgo testa, add 80% ethanol with a material-to-liquid ratio of 1:6 (W / V), stir and extract twice at a water bath temperature of 60°C, and extract for 4 hours each time , (Note: After adding liquid, seal the mouth of the beaker with plastic wrap to prevent the volatilization of ethanol). After the leaching is finished, filter with a suction filter to collect the filtrate. Concentrate the filtrate with a vacuum rotary evaporator at a temperature of 55° C. and a pressure of 0.008-0.009 MPa, and concentrate under reduced pressure. Vacuum-dried at 60°C to obtain ginkgolic acid extract. The properties are: light brown extract, slightly smelly, soluble in alcohol, insoluble in water; weighed, and determined the content of ginkgolic acid (mg / g).
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Embodiment 2
[0083] The extraction process of ginkgo phenolic acid from ginkgo fruit ginkgo is as follows: peel the ginkgo fruit, put it into a tissue grinder, and pulverize it. Accurately weigh a certain amount of pulverized Ginkgo fruit, add 80% ethanol with a solid-liquid ratio of 1:10 (W / V), and stir and extract twice at a water bath temperature of 60° C., each extraction time is 4 hours, (Note : After adding liquid, the mouth of the beaker is sealed with plastic wrap to prevent the volatilization of ethanol). After leaching finishes, centrifuge (5000 rpm, 15 minutes), get supernatant. Concentrate the supernatant with a vacuum rotary evaporator under the conditions of temperature 55°C, pressure 0.008-0.009MPa, concentrate under reduced pressure, and vacuum-dry at 60°C to obtain ginkgolic acid extract, which has the following properties: light brown extract, slightly odorous , Soluble in alcohol, insoluble in water. Weigh and determine the content of ginkgolic acid (mg / g).
[0084] G...
Embodiment 3
[0088] The extraction process of ginkgolic acid in ginkgo leaves is as follows: cut the ginkgo leaves into pieces, put them into a pulverizer and pulverize them. Accurately take a certain amount of crushed Ginkgo biloba, add 80% ethanol with a solid-liquid ratio of 1:6 (W / V), and stir and extract 2 times at a water bath temperature of 60° C., each extraction time is 4 hours, ( Note: After adding liquid, seal the mouth of the beaker with plastic wrap to prevent the volatilization of ethanol). After leaching finishes, centrifuge (5000 rpm, 15 minutes), get supernatant. Concentrate the supernatant with a vacuum rotary evaporator under the conditions of temperature 55°C, pressure 0.008-0.009MPa, concentrate under reduced pressure, and vacuum-dry at 60°C to obtain ginkgolic acid extract, which has the following properties: light brown extract, slightly odorous , Soluble in alcohol, insoluble in water. Weigh and determine the content of ginkgolic acid (mg / g).
[0089] Ginkgolic a...
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