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Chitosan nanoparticle preparation of ceftiofur sodium, and preparation method thereof

A technology of chitosan nanoparticles and ceftiofur sodium, which is applied in the directions of antibacterial drugs and powder transportation, can solve the problems of poor physical stability, easy sedimentation, short maintenance time, etc., and achieves simple and reliable preparation method and low price. Inexpensive, quality controllable results

Inactive Publication Date: 2012-01-18
SICHUAN JINRUIKE ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Injections face the shortcoming of maintaining the effective concentration of drugs in the body for a short time. Although ceftiofur sodium suspension solves this problem to a certain extent, it also has high viscosity, easy sedimentation, poor physical stability, and intramuscular injection. local irritation

Method used

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  • Chitosan nanoparticle preparation of ceftiofur sodium, and preparation method thereof
  • Chitosan nanoparticle preparation of ceftiofur sodium, and preparation method thereof
  • Chitosan nanoparticle preparation of ceftiofur sodium, and preparation method thereof

Examples

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Effect test

example 1

[0021] Dissolve 3 mg of chitosan in 10 ml of 0.3% acetic acid solution to obtain a chitosan solution (solution A); dissolve 4.52 mg of sodium tripolyphosphate and 10 mg of ceftiofur sodium in 4 ml of deionized water to obtain a solution containing The sodium tripolyphosphate solution (solution B) of ceftiofur sodium, under the condition of magnetic stirring, solution B is slowly added dropwise in the solution A, continue stirring for 30min to obtain the ceftiofur sodium chitosan nanoparticle preparation, and the stirring rate is 400rpm.

example 2

[0023] Dissolve 7 mg of chitosan in 10 ml of 0.3% acetic acid solution to obtain a chitosan solution (solution A); dissolve 10.52 mg of sodium tripolyphosphate and 20 mg of ceftiofur sodium in 4 ml of deionized water to obtain a solution containing The sodium tripolyphosphate solution (solution B) of ceftiofur sodium, under the condition of magnetic stirring, solution B is slowly added dropwise in the solution A, continue stirring for 60min to obtain the ceftiofur sodium chitosan nanoparticle preparation, and the stirring rate is 1200rpm.

example 3

[0025] Dissolve 4 mg of chitosan in 10 ml of 0.3% acetic acid solution to obtain a chitosan solution (solution A); dissolve 6 mg of sodium tripolyphosphate and 8 mg of ceftiofur sodium in 4 ml of deionized water to obtain a solution containing cephalosporin Sodium tripolyphosphate solution (solution B) of sodium thiofur, under magnetic stirring conditions, slowly add solution B dropwise to solution A, continue stirring for 10 minutes to obtain ceftiofur sodium chitosan nanoparticle preparation, stirring speed is 800rpm .

[0026] Characterization of ceftiofur sodium chitosan nanoparticle preparation:

[0027] Observation of appearance

[0028] Take the colloidal solution of ceftiofur sodium chitosan nanoparticle preparation, add an appropriate amount of ultrapure water (0.22 μm filter) to dilute, negatively stain with 1.5% (w / v) phosphotungstic acid, drop it on the coated electron microscope copper grid, After drying, observe the appearance of nanoparticles under a transmiss...

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Abstract

The invention belongs to the field of drug nanopreparation, especially relates to a chitosan nanoparticle preparation of ceftiofur sodium, and a preparation method thereof. The chitosan nanoparticle preparation is characterized in that: the preparation comprises 3-7 mg / mL of chitosan, 1.13-2.63 mg / mL of sodium tripolyphosphate and 2-5 mg / mL of ceftiofur sodium. The preparation method adopts an ionic crosslinking method and comprises the following steps: dissolving the chitosan, dissolving the ceftiofur sodium in the sodium tripolyphosphate solution, adding the sodium tripolyphosphate solution containing the ceftiofur sodium to the chitosan solution under magnetic stirring, and the like. According to the present invention, the ceftiofur sodium chitosan nanoparticles have target distribution and slow release property, such that the action time of the drug can be prolonged, the efficacy can be increased, the toxic and side-effect of the drug can be reduced, the antibacterial stability of the drug can be improved; the preparation method has characteristics of simpleness, reliability and controllable quality, and is suitable for the industrial production.

Description

technical field [0001] The invention relates to the field of pharmaceutical nano preparations, in particular to a ceftiofur sodium chitosan nano particle preparation and a preparation method thereof. [0002] Background technique [0003] Ceftiofur sodium (Ceftiofur sodium) is the third generation of cephalosporin antibiotics for veterinary clinical use. It is a broad-spectrum antibacterial drug and is widely used in clinical practice. Antibacterial effect. Ceftiofur acts on transcriptional peptidases to block the synthesis of mucopeptides, resulting in the loss of bacterial cell walls to achieve bactericidal effect. Ceftiofur has a stable β-lactam ring, which is not easily destroyed by drug-resistant bacteria, and can act on gram-positive and gram-negative bacteria producing β-lactamase. [0004] The preparations of ceftiofur sodium include ceftiofur sodium injection and ceftiofur sodium suspension. Injections face the shortcoming of maintaining the effective concentrat...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/546A61K47/36A61P31/04
Inventor 姜南符华林姜均
Owner SICHUAN JINRUIKE ANIMAL PHARMA
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