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Preparation method of taste-masked suspension granules of Gegenqinlian decoction

A technology of Gegen Qinlian Decoction and suspension granules, applied to medical preparations containing no active ingredients, medical preparations containing active ingredients, anti-inflammatory agents, etc., can solve problems such as lack of taste, improve taste, mask Taste effect synergistic, effect of reducing perception

Active Publication Date: 2013-06-12
安徽天祥药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the compound has been made into various preparation forms, such as Gegen Qinlian tablets and Gegen Qinlian pills recorded in the 2010 edition of "Chinese Pharmacopoeia", but there is no dosage form with good taste and suitable for children on the market.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Get Pueraria root formula granule 200g, particle size is 200 ~ 300 micron, take enteric polyacrylic acid resin as coating material, consumption is to be equivalent to 30% of drug granule weight before coating, carry out coating in fluidized bed, After coating, the granules are ready for use.

[0034] Get 200g of Coptidis formula granules, the particle size is 200 ~ 300 microns, take enteric polyacrylic acid resin as the coating material, the dosage is equivalent to 50% of the weight of the drug granules before coating, and coat in a fluidized bed, After coating, the granules are ready for use.

[0035] Get 200g of Scutellaria baicalensis formula granules, the particle size is 200~300 microns, take enteric polyacrylic acid resin as the coating material, and the dosage is 40% of the weight of the drug granules before coating, and coat in a fluidized bed, After coating, the granules are ready for use.

[0036] According to sodium alginate: carrageenan: konjac gum: licori...

Embodiment 2

[0039] Get Pueraria root formula granule 200g, particle size is 100~250 micron, take hypromellose acetate succinate as coating material, consumption is to be equivalent to 50% of the drug granule weight before coating, carry out in fluidized bed Coating, after coating, the granules are ready for use.

[0040] Get 200g of Coptidis formula granules, the particle size is 100~250 microns, take hypromellose acetate succinate as the coating material, and the dosage is 100% of the weight of the drug granules before coating, and carry out in a fluidized bed. Coating, after coating, the granules are ready for use.

[0041] Take 200g of Scutellaria baicalensis formula granules, the particle size is 100~250 microns, take hypromellose acetate succinate as the coating material, and the dosage is 60% of the weight of the drug granules before coating, and carry out in a fluidized bed. Coating, after coating, the granules are ready for use.

[0042]According to the weight ratio of hydroxypr...

Embodiment 3

[0045] Get Pueraria root formula granule 200g, particle size is 250 ~ 350 micron, take hypromellose phthalate as coating material, consumption is to be equivalent to 40% of drug granule weight before coating, in fluidized bed Coating is carried out in the medium, and the granules are ready for use after coating.

[0046] Get 200g of Coptidis Rhizoma Formula Granules, the particle size is 250 ~ 350 microns, take hypromellose phthalate as the coating material, and the consumption is equivalent to 40% of the weight of the drug granules before coating, in a fluidized bed Coating is carried out in the medium, and the granules are ready for use after coating.

[0047] Get 200g of Scutellaria baicalensis formula granules, the particle size is 250 ~ 350 microns, take hypromellose phthalate as the coating material, and the dosage is 25% of the weight of the drug granules before coating, in a fluidized bed Coating is carried out in the medium, and the granules are ready for use after c...

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Abstract

The invention relates to a preparation method of taste-masked suspension granules of Gegenqinlian decoction. The preparation method comprises the following steps of 1, taking appropriate amounts of dispensing granules of three traditional Chinese medicines comprising radix puerariae, coptis chinensis and scutellaria baicalensis and respectively carrying out coating processes in a fluidized bed through adopting one or more polymers as coating materials to obtain coated granules for next use, 2, taking an appropriate amount of at least one suspending agent, mixing uniformly the at least one suspending agent and radix glycyrrhizae preparata dispensing granules, then adding an appropriate amount of an adhesive into the mixture to prepare into granules by a wet method, drying the prepared granules in an oven, and then spraying an appropriate amount of an ethanol solution as an aromatic to obtain suspending agent-containing radix glycyrrhizae preparata dispensing granules after ethanol is volatilized, and 3, weighing appropriate amounts of the suspending agent-containing radix glycyrrhizae preparata dispensing granules and the coated granules containing radix puerariae, coptis chinensisand scutellaria baicalensis, mixing well, and carrying out sub-packaging to obtain the taste-masked suspension granules of Gegenqinlian decoction, wherein the one or more polymers as coating materials are selected from enteric-coated polyacrylic resin, hypromellose acetate succinate and hydroxypropyl methylcellulose phthalate. The invention provides the preparation method of the taste-masked suspension granules of Gegenqinlian decoction. The preparation method is also suitable for taste masking of a traditional Chinese medicine with a bitter taste or a fishy smell.

Description

technical field [0001] The invention relates to a preparation method of Gegen Qinlian Decoction taste-masking suspension granules. It belongs to the field of traditional Chinese medicine preparation. Background technique [0002] Traditional Chinese medicine has moderate effects and few side effects, and has certain advantages in clinical use. However, its taste and taste are the main factors affecting the compliance of patients, especially children, when taking medicine. Controlling the taste of traditional Chinese medicine within an acceptable range has always been a research hotspot in the field of traditional Chinese medicine. The principle of drug taste-masking includes two categories, that is, reducing the sensitivity of taste buds to bitter taste and reducing the amount of drug in contact with taste buds, and related drug taste-masking techniques include adding masking agent method, cyclodextrin inclusion method, ion exchange resin method, etc. However, due to the co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/718A61K47/46A61K47/26A61K47/32A61K47/38A61K9/16A61P29/00A61P31/04A61P31/12A61P1/00A61P39/00A61P37/04A61P43/00
Inventor 陈盛君过科家周叶周嘉琳
Owner 安徽天祥药业有限公司
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