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Rg2 group and Rh1 group of red ginseng saponin and preparation method as well as applications in preparing cosmetics preventing skin aging

A technology of ginsenosides and ginsenosides, applied in the field of mixed saponins of Rg2 group, can solve difficult problems, achieve human body safety, less side effects, and promote the effect of skin fibroblast collagen synthesis function

Active Publication Date: 2013-08-21
SUNFLOWER PHARM GRP (TIANJIN) DRUG RES INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the separation and extraction from red ginseng is composed of 20 ( S )-Rg2, 20( R )-Rg2, Rg4, Rg6 and other four kinds of saponins composed of Rg2 group saponins, separated and extracted by 20 ( S )-Rh1, 20( R )-Rh1, Rk3, Rh4 and other four kinds of saponins composed of Rh1 group saponins, which are very difficult and have not been reported so far

Method used

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  • Rg2 group and Rh1 group of red ginseng saponin and preparation method as well as applications in preparing cosmetics preventing skin aging
  • Rg2 group and Rh1 group of red ginseng saponin and preparation method as well as applications in preparing cosmetics preventing skin aging
  • Rg2 group and Rh1 group of red ginseng saponin and preparation method as well as applications in preparing cosmetics preventing skin aging

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Preparation of red ginseng rare saponin Rg2 group by transforming ginsenoside Re with ginseng self-enzyme and extract of water-soluble substances:

[0033] Ginseng root contains its own ginsenoside enzymes (C Zhang, H Yu, Y Bao, L An, F Jin (金凤雄): Chem. Pharm. Bull ., 2001, 49(7), 795-798.; Process BioChem ., 2002, 37, 793-798.). The present invention extracts the extract of ginseng self-enzymes and water-soluble substances in ginseng roots, and reacts with ginsenoside Re to obtain 20 ( S )-Rg2, 20(R )-Rg2, Rg4 and Rg6 monomer saponins in which the proportion of saponins in Rg2 group is equivalent to that in red ginseng.

[0034] 1. Preparation of extracts of ginseng's own enzymes and water-soluble substances:

[0035] Cut 3.5 kg of fresh ginseng (equivalent to 1 kg of dry ginseng) into 2mm thick slices, add 8 liters of 95% ethanol, extract ginsenosides at 50-60°C for 6 hours, and separate the extract; add 8 1 liter of 70-75% ethanol extraction, a total of 3 e...

Embodiment 2

[0066] Use the ginseng self-enzyme and the extract of water-soluble substances obtained in Example 1 to convert ginsenoside Rg1 to prepare the preparation of Rh1 group: 50 grams of ginsenoside Rg1 (available in the market) was added to 300 ml of water, ground, and then Add 100 milliliters of ginseng self-enzyme and water-soluble substance extract and 600 milliliters of water prepared in Example 1, react at 80-110 ° C for 20-2 hours, almost all ginsenoside Rg1 is converted into red ginsenoside 20 ( S )-Rh1, 20( R )-Rh1, Rk3 and Rh4. The reaction solution was adsorbed on a column of 1 liter of macroporous resin (HP-20 macroporous resin, produced by Mitsubishi Corporation of Japan; or AB-8 macroporous resin, produced by Tianjin Nankai University), and washed off unadsorbed glycosides with 8 liters of water. Sugar and slag; then use 6 liters of 75-80% ethanol to elute saponin, and its eluate is concentrated under reduced pressure and dried to obtain 30 grams of 20 ( S )-Rh1, 20(...

Embodiment 3

[0086] Adding organic acid to the extract of ginseng's own enzymes and water-soluble substances can improve the effect of converting Re to prepare mixed saponins of Rg2 group.

[0087] Add 5 grams of ginsenoside Re to 22 milliliters of water, grind, then add 3 milliliters of the ginseng self-enzyme and water-soluble substance extract of Example 1, add 25 milliliters of lactic acid, react at 70 ° C for 2 hours, and dilute with 300 milliliters of water, Repeatedly adsorbing saponin on a 100 ml macroporous resin column, washing the residue with water, then eluting with 400 ml of 70% ethanol, concentrating under reduced pressure and drying to obtain 3.4 grams of 20( S )-Rg2, 20( R )-Rg2 group Rg2 mixed saponins composed of Rg4 and Rg6. The composition of the mixed saponins of the Rg2 group was detected by HPLC, and its composition was similar to that of the mixed saponins of the Rg2 group in Example 1.

[0088] In the above reaction, the reaction concentration of ginsenoside Re ...

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Abstract

The invention discloses an Rg2 group and an Rh1 group of red ginseng saponin and a preparation method as well as applications in preparing cosmetics preventing skin aging. Extracts which are extracted from ginseng roots, do not contain saponin, and contain saponin enzyme of ginseng and other water-soluble matters react with ginsenoside Re to obtain red ginseng mixed saponin Rg2 group consisting of red ginseng rare saponin 20(S)-Rg2, 20(R)-Rg2, Rg4 and Rg6, and the extracts react with ginsenoside Rg1 to obtain the red ginseng mixed saponin Rh1 group consisting of red ginseng rare saponin 20(S)-Rh1, 20(R)-Rh1, Rh4 and Rk3. Compared with a saponin Rg2 monomer and a saponin Rh1 monomer, the function of the Rg2 group and Rh1 group of red ginseng mixed saponin for promoting skin fibroblast collagen synthesis is improved obviously, the Rg2 group and Rh1 group of red ginseng mixed saponin are more safe to skin and human bodies, and have less side effects.

Description

technical field [0001] The present invention relates to very safe to human body and skin: it is composed of red ginseng rare saponin 20 ( S )-Rg2, 20( R )-Rg2, Rg4 and Rg6 four kinds of Rg2 group mixed saponins, composed of red ginseng rare saponins 20 ( S )-Rh1, 20( R )-Rh1, Rh4 and Rk3 and other four kinds of Rh1 group mixed saponins and preparation method; the prepared red ginseng rare saponins Rg2 group and Rh1 group mixed saponins have the function of promoting collagen synthesis of skin fibroblasts, and are compatible with other cosmetics The main ingredients are mixed to prepare anti-aging cosmetics. Background technique [0002] With the increase of age, the amount of collagen in the dermis will gradually decrease (the collagen content of young people's dermis generally accounts for more than 90%), and because the skin is often exposed to the outside world, compared with normal skin, ultraviolet photoaging skin The amount of collagen is also significantly reduced...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/97A61K8/63A61Q19/08
Inventor 金凤燮鱼红闪
Owner SUNFLOWER PHARM GRP (TIANJIN) DRUG RES INST CO LTD
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