Rg2 group and Rh1 group of red ginseng saponin and preparation method as well as applications in preparing cosmetics preventing skin aging
A technology of anti-skin aging and rare saponins of red ginseng, which is applied in cosmetics, cosmetic preparations, skin care preparations, etc., can solve difficult problems, achieve human safety, have few side effects, and promote skin fibroblast collagen synthesis The effect of the function
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0032] Preparation of red ginseng rare saponin Rg2 group by transforming ginsenoside Re with ginseng self-enzyme and extract of water-soluble substances:
[0033] Ginseng root contains its own ginsenoside enzymes (C Zhang, H Yu, Y Bao, L An, F Jin (金凤雄): Chem. Pharm. Bull ., 2001, 49(7), 795-798.; Process BioChem., 2002, 37, 793-798.). The present invention extracts the extract of ginseng self-enzymes and water-soluble substances in ginseng roots, and reacts with ginsenoside Re to obtain 20 ( S )-Rg2, 20( R )-Rg2, Rg4 and Rg6 monomer saponins in which the proportion of saponins in Rg2 group is equivalent to that in red ginseng.
[0034] 1. Preparation of extracts of ginseng's own enzymes and water-soluble substances:
[0035] Cut 3.5 kg of fresh ginseng (equivalent to 1 kg of dry ginseng) into 2mm thick slices, add 8 liters of 95% ethanol, extract ginsenosides at 50-60°C for 6 hours, and separate the extract; add 8 1 liter of 70-75% ethanol extraction, a total of 3 extr...
Embodiment 2
[0065] Use the ginseng self-enzyme and the extract of water-soluble substances obtained in Example 1 to convert ginsenoside Rg1 to prepare the preparation of Rh1 group: 50 grams of ginsenoside Rg1 (available in the market) was added to 300 ml of water, ground, and then Add 100 milliliters of ginseng self-enzyme and water-soluble substance extract and 600 milliliters of water prepared in Example 1, react at 80-110 ° C for 20-2 hours, almost all ginsenoside Rg1 is converted into red ginsenoside 20 ( S )-Rh1, 20( R )-Rh1, Rk3 and Rh4. The reaction solution was adsorbed on a column of 1 liter of macroporous resin (HP-20 macroporous resin, produced by Mitsubishi Corporation of Japan; or AB-8 macroporous resin, produced by Tianjin Nankai University), and washed off unadsorbed glycosides with 8 liters of water. Sugar and slag; then use 6 liters of 75-80% ethanol to elute saponin, and its eluate is concentrated under reduced pressure and dried to obtain 30 grams of 20 ( S )-Rh1, 20(...
Embodiment 3
[0085] Adding organic acid to the extract of ginseng's own enzymes and water-soluble substances can improve the effect of converting Re to prepare mixed saponins of Rg2 group.
[0086] Add 5 grams of ginsenoside Re to 22 milliliters of water, grind, then add 3 milliliters of the ginseng self-enzyme and water-soluble substance extract of Example 1, add 25 milliliters of lactic acid, react at 70 ° C for 2 hours, and dilute with 300 milliliters of water, Repeatedly adsorbing saponin on a 100 ml macroporous resin column, washing the residue with water, then eluting with 400 ml of 70% ethanol, concentrating under reduced pressure and drying to obtain 3.4 grams of 20( S )-Rg2, 20( R )-Rg2 group Rg2 mixed saponins composed of Rg4 and Rg6. The composition of the mixed saponins of the Rg2 group was detected by HPLC, and its composition was similar to that of the mixed saponins of the Rg2 group in Example 1.
[0087] In the above reaction, the reaction concentration of ginsenoside Re ...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com