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Method for preparing staged absorbable ha/acp composite coating on titanium implant surface

A composite coating, titanium implant technology, applied in the field of biomedical materials, can solve the problems of single HA coating and ACP coating biological properties, etc., achieve good healing effect, improve biological activity, and easy to operate.

Inactive Publication Date: 2011-12-21
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by the present invention is to provide a method for preparing a staged absorbable HA / ACP composite coating on the surface of a titanium implant, so as to solve the deficiency of the biological performance of a single HA coating and ACP coating, so that the coating can High bioactivity and phasic and osseointegration properties

Method used

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  • Method for preparing staged absorbable ha/acp composite coating on titanium implant surface
  • Method for preparing staged absorbable ha/acp composite coating on titanium implant surface
  • Method for preparing staged absorbable ha/acp composite coating on titanium implant surface

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The method for the HA / ACP composite coating prepared by the electrochemical method on the surface of metal titanium comprises the following steps:

[0019] (1) Prepare an electrolyte solution containing HA constituent elements. Among them, the constituent elements of HA are CaCl 2 and NH 4 h 2 PO 4 Provided, its conductive agent is NaCl; Ca 2+ The concentration is 0.6mmol / L, PO 4 3- The concentration of NaCl is 0.36mmol / L, and the concentration of NaCl is 0.1mol / L. Dissolve the analytically pure reagents in distilled water one by one according to the above concentration requirements, and then adjust the pH value of the electrolyte to 6 with ammonia water or hydrochloric acid solution.

[0020] (2) Prepare the electrolyte solution containing the constituent elements of ACP. Among them, the constituent elements of ACP are composed of CaCl 2 and NH 4 h 2 PO 4 Provided, the conductive agent is NaCl, and the stable ion of ACP is cit 3- ; Ca 2+ The concentration...

Embodiment 2

[0027] The HA / ACP composite coating prepared by the electrochemical method on the surface of metal titanium comprises the following steps:

[0028] (1) Prepare an electrolyte solution containing HA constituent elements. Among them, the constituent elements of HA are CaCl 2 and NH 4 h 2 PO 4 Provided, the conductive agent is NaCl; Ca 2+ The concentration is 2.4mmol / L, PO 4 3- The concentration of NaCl is 1.44mmol / L, and the concentration of NaCl is 0.1mol / L. According to the above concentration requirements, various analytically pure reagents were dissolved in distilled water one by one, and then the pH value of the electrolyte was adjusted to 6 with ammonia water or hydrochloric acid solution.

[0029] (2) Prepare the electrolyte solution containing the constituent elements of ACP and the stable ions of ACP. Among them, the constituent elements of ACP are composed of CaCl 2 and NH 4 h 2 PO 4 Provided, the stable ion of ACP is SiO 3 2- and cit 3- , the conductive...

Embodiment 3

[0036] The HA / ACP composite coating prepared by the electrochemical method on the surface of metal titanium comprises the following steps:

[0037] (1) Prepare an electrolyte solution containing HA constituent elements. Among them, the constituent elements of HA are CaCl 2 and NH 4 h 2 PO 4 Provided, the conductive agent is NaCl; Ca 2+ The concentration is 1.2mmol / L, PO 4 3- The concentration of NaCl is 0.72mmol / L, and the concentration of NaCl is 0.1mol / L. Dissolve the analytically pure reagents in distilled water one by one according to the above concentration requirements, and then adjust the pH value of the electrolyte to 6 with ammonia water or hydrochloric acid solution.

[0038] (2) Prepare the electrolyte solution containing the constituent elements of ACP. Among them, the constituent elements of ACP are composed of CaCl 2 and NH 4 h 2 PO 4 Provided, the conductive agent is NaCl, and the ACP stable ion is Mg 2+ ; Ca 2+ The concentration is 1.2mmol / L, PO ...

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Abstract

The invention discloses a method for preparing a staged absorbable HA / ACP composite coating on the surface of a titanium implant. Using platinum as the anode and the metal titanium substrate as the cathode, the two electrodes are first immersed in the container of the electrolyte solution containing the constituent elements of hydroxyapatite, so that the cathodic reduction reaction occurs on the surface of the metal titanium substrate, and thus the surface of the metal titanium substrate First deposit a layer of HA coating; then take out the two electrodes and then immerse them in the container of electrolyte solution containing the constituent elements of amorphous calcium phosphate and stable ions of amorphous calcium phosphate, so that the cathodic reduction reaction continues to occur on the surface of the metal titanium substrate , thereby depositing a layer of ACP coating on the surface of the HA coating, thereby depositing the HA / ACP composite coating on the surface of the metal titanium substrate; after cleaning, removing the electrolyte attached to the surface of the metal titanium substrate, and drying in a drying oven. The composite coating formed by the invention has better biological activity, and can regulate the biological response in the whole process of implant implantation.

Description

technical field [0001] The invention relates to an electrochemical method for preparing a bioactive HA / ACP composite calcium phosphate coating on the surface of a titanium implant, belonging to the field of biomedical materials. Background technique [0002] Hydroxyapatite (HA) coating has excellent biological activity and chemical stability. After implanted in the human body, it can chemically bond with bone tissue. The solubility of HA is low, and the integration rate with bone is slow in the early stage. The effect is obvious in the healing process. The amorphous calcium phosphate (ACP) coating has good biological properties and high biodegradability. The high biodegradability enables it to quickly react with bone tissue in the early stage of implantation, and it is also easy to react before the biological effect occurs. Just dissolve it all. However, neither the single HA coating nor the ACP coating can meet the needs of the biological effect of the coating during the...

Claims

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Application Information

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IPC IPC(8): C25D9/08A61L27/06A61L27/32A61L27/42
Inventor 王小祥李登虎焦明洁林东洋江源胜
Owner ZHEJIANG UNIV
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